Filtyp
This thesis describes functional and structural studies of the human protein α1-microglobulin (A1M), an evolutionarily well-conserved 26 kDa plasma and tissue protein mainly synthesized in the liver. A1M belongs to the lipocalin protein family. Lipocalins share a very similar structur, an 8-stranded β-barrel forming a hydrophobic pocket. A1M has reductase and radical scavenging properties. A1M als
Background: We have previously reported that expression of the RNA-and DNA-binding protein RBM3 is associated with a good prognosis in breast cancer and ovarian cancer. In this study, the prognostic value of immunohistochemical RBM3 expression was assessed in incident cases of malignant melanoma from a prospective population-based cohort study. Methods: Until Dec 31(st) 2008, 264 incident cases of
Background: Hardwood spent sulfite liquor (HSSL) is a by-product of acid sulfite pulping process that is rich in xylose, a monosaccharide that can be fermented to ethanol by Scheffersomyces stipitis. However, HSSL also contains acetic acid and lignosulfonates that are inhibitory compounds of yeast growth. The main objective of this study was the use of an evolutionary engineering strategy to obtai
Background: Malignant melanoma is the most lethal form of skin cancer with a variable clinical course even in patients with thin melanomas and localized disease. Despite increasing insights into melanoma biology, no prognostic biomarkers have yet been incorporated into clinical protocols. Reduced expression of the RNA binding motif protein 3 (RBM3) has been shown to correlate with tumour progressi
Objective acoustic parameters have been measured in 30 school classrooms. These parameters include usual descriptors of the acoustic quality from the listeners’ standpoint, such as reverberation time, speech transmission index, and background noise level, and two descriptors of the acoustic properties for a speaker: Voice support and room gain. This paper describes the measurement method for these
Bone Scan Index (BSI) is a quantitative measurement of tumour burden in the skeleton calculated from bone scan images. When analysed at the time of diagnosis, it has been shown to provide prognostic information on survival in men with metastatic prostate cancer (PCa). In this study, we evaluated the prognostic value of BSI during androgen deprivation therapy (ADT).
Following the East Asian success story Indonesia also subscribed to a model with increased productivity, income and equity through modernisation of agriculture. When it was hit by a severe crisis in 1997, Indonesia was regarded as one of the up and coming tigers of Southeast Asia. The crisis indicated that something was seriously wrong in the structure of the economy necessitating a re-examination
abstract is not available
Accelerated pavement wear is one of the major environmental disadvantages of studded tyres in northern regions and results in increased levels of PM10. Measurements of PM10 in a road simulator hall have been used to study the influence of pavement properties, tyre type and vehicle speed on pavement wear. The test set-up included three different pavements (one granite and two quartzite with differe
This volume 90 of the Yearbook for Swedish Liturgical Life is dedicated to hymnological studies. It includes articles by Ingvar Bengtsson, Stephan Borgehammar, Anna J. Evertsson, Liza L Lundkvist & Ragnar Holte. All articles are in Swedish with a summary in English.
We present the results of a search for gravitational waves associated with 154 gamma-ray bursts (GRBs) that were detected by satellite-based gamma-ray experiments in 2009-2010, during the sixth LIGO science run and the second and third Virgo science runs. We perform two distinct searches: a modeled search for coalescences of either two neutron stars or a neutron star and black hole, and a search f
Phylogenetic relationships of the family Lobariaceae (Lecanoromycetes, Ascomycota) were reconstructed using direct optimization of nuclear ITS and LSU, and mitochondrial SSU rDNA sequences. Delimitations of the genera currently included in the family were investigated. Relationships of austral temperate taxa occurring in New Zealand, Australia and southern South America were studied in detail. Fin
Background: Glioblastoma are highly aggressive tumors with an average survival time of 12 months with currently available treatment. We have previously shown that specific embryonic neural progenitor cells (NPC) have the potential to target glioma growth in the CNS of rats. The neural progenitor cell treatment can cure approximately 40% of the animals with malignant gliomas with no trace of a tumo
beta-Microseminoprotein (MSP), a 10kDa seminal plasma protein, forms a tight complex with cysteine-rich secretory protein 3 (CRISP-3) from granulocytes. The 3D structure of human MSP has been determined but there is as yet no 3D structure for CRISP-3. We have now studied the complex between human MSP and CRISP-3 with multidimensional NMR. (15)N-HSQC spectra show substantial differences between fre
The increasing demand for solid biofuels, such as logging residue fuels, has highlighted the importance of considering that, in contrast to fossil fuels, biofuels are produced in dynamic ecosystems. The environmental effects of changes in management policy, whether positive and negative, are not obvious. For example, calculations of the carbon budget in single forest stands show that the carbon ba
This article describes the systematic design of a control structure for a biological wastewater treatment process as given by the test-bed Benchmark Simulation Model No. 1 (BSM1) and Activated Sludge Model No. 1 (ASM1). The objective of this work was to formalize and implement a systematic and yet simple procedure for the selection of control structures in wastewater treatment plants (WWTPs) and t
Wind tunnels allow researchers to investigate animals' flight under controlled conditions, and provide easy access to the animals during flight. These increasingly popular devices can benefit integrative migration biology by allowing us to explore the links between aerodynamic theory and migration as well as the links between flight behavior and physiology. Currently, wind tunnels are being used t
During development primary afferents grow into and establish neuronal connections in the spinal cord, conveying information of the anatomical and mechanical properties of the body. This body representation forms the basis for how we perceive sensory information and control our movements. Subsequently, the strength of the sensory input to spinal sensorimotor circuits is functionally adjusted by an
