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Downstream effects of polypathology on neurodegeneration of medial temporal lobe subregions

The medial temporal lobe (MTL) is a nidus for neurodegenerative pathologies and therefore an important region in which to study polypathology. We investigated associations between neurodegenerative pathologies and the thickness of different MTL subregions measured using high-resolution post-mortem MRI. Tau, TAR DNA-binding protein 43 (TDP-43), amyloid-β and α-synuclein pathology were rated on a sc

Manipulating crystallization dynamics through chelating molecules for bright perovskite emitters

Molecular additives are widely utilized to minimize non-radiative recombination in metal halide perovskite emitters due to their passivation effects from chemical bonds with ionic defects. However, a general and puzzling observation that can hardly be rationalized by passivation alone is that most of the molecular additives enabling high-efficiency perovskite light-emitting diodes (PeLEDs) are che

Effect of Anti-inflammatory Treatment with AMD3100 and CX3CR1 Deficiency on GABAA Receptor Subunit and Expression of Glutamate Decarboxylase Isoforms After Stroke

Following stroke, attenuation of detrimental inflammatory pathways might be a promising strategy to improve long-term outcome. In particular, cascades driven by pro-inflammatory chemokines interact with neurotransmitter systems such as the GABAergic system. This crosstalk might be of relevance for mechanisms of neuronal plasticity, however, detailed studies are lacking. The purpose of this study w

Preventing suicide in post-secondary students : a scoping review of suicide prevention programs

Suicide among students enrolled in post-secondary education, including university or college, is a major public health concern. Previous research has examined the effectiveness of suicide prevention programs for this population. However, the effective elements of these interventions remain unknown. This study reviewed the literature on suicide prevention programs for post-secondary students, explo

Mysteries of the trade? Skill-specific local agglomeration economies

Do workers benefit from proximity to other workers with similar skill sets? This question dates back at least to Alfred Marshall. We use occupation groups to proxy skill sets and show that the answer likely depends on geographical levels, as well on regional hierarchy. Using longitudinal Swedish data, we document robust evidence consistent with highly localized spillovers at the level of sub-city

Data-driven control of infinite dimensional systems : Application to a continuous crystallizer

Controlling infinite dimensional models remains a challenging task for many practitioners since they are not suitable for traditional control design techniques or will result in a high-order controller too complex for implementation. Therefore, the model or the controller need to be reduced to an acceptable dimension, which is time-consuming, requires some expertise and may introduce numerical err

Attitude Control on SU(2) : Stability, Robustness, and Similarities

This paper concerns trajectory tracking control of attitude dynamics configured on SU(2). Inspired by a popular geometric tracking controller on SO(3), differential geometric tools are used to derive both continuous and discontinuous attitude controllers on the SU(2) manifold, relating these to preexisting controllers operating with imaginary quaternion errors. Additionally, a robustness result is

Tuning and Analysis of Geometric Tracking Controllers on SO(3)

This paper concerns the robustness of attitude controllers for dynamics configured on the SO(3) manifold and poses a set of bilinear matrix inequalities to find an optimal controller tuning with respect to (i) the ultimate bound of the error-state trajectories when perturbed by naturally arising disturbances, and (ii) the worst-case decay rate of the tracking errors. The presented optimization pro

A search for the decays of stopped long-lived particles at √s = 13 TeV with the ATLAS detector

A search for long-lived particles, which have come to rest within the ATLAS detector, is presented. The subsequent decays of these particles can produce high-momentum jets, resulting in large out-of-time energy deposits in the ATLAS calorimeters. These de- cays are detected using data collected during periods in the LHC bunch structure when collisions are absent. The analysed dataset is composed o

Search for supersymmetry in events with four or more charged leptons in 139 fb−1 of √s = 13 TeV pp collisions with the ATLAS detector

A search for supersymmetry in events with four or more charged leptons (electrons, muons and τ-leptons) is presented. The analysis uses a data sample corresponding to 139 fb−1 of proton-proton collisions delivered by the Large Hadron Collider at s = 13 TeV and recorded by the ATLAS detector. Four-lepton signal regions with up to two hadronically decaying τ-leptons are designed to target several su

Predicting future stability of ecosystem functioning under climate change

To maintain food security under global change, we need to consider the stability of ecosystem functioning into the future, particularly in resource production landscapes such as agricultural pasture. With ongoing climate change, extreme climatic events are predicted to become more frequent and severe globally, impacting crop production. The whole process of farming will become more uncertain, from

In situ passivation of GaxIn(1−x)P nanowires using radial AlyIn(1−y)P shells grown by MOVPE

GaxIn(1−x)P nanowires with suitable bandgap (1.35-2.26 eV) ranging from the visible to near-infrared wavelength have great potential in optoelectronic applications. Due to the large surface-to-volume ratio of nanowires, the surface states become a pronounced factor affecting device performance. In this work, we performed a systematic study of GaxIn(1−x)P nanowires' surface passivation, utilizing A

Nonhydrolysable Analogues of (p)ppGpp and (p)ppApp Alarmone Nucleotides as Novel Molecular Tools

While alarmone nucleotides guanosine-3',5'-bisdiphosphate (ppGpp) and guanosine-5'-triphosphate-3'-diphosphate (pppGpp) are archetypical bacterial second messengers, their adenosine analogues ppApp (adenosine-3',5'-bisdiphosphate) and pppApp (adenosine-5'-triphosphate-3'-diphosphate) are toxic effectors that abrogate bacterial growth. The alarmones are both synthesized and degraded by the members

How did micro-mobility change in response to COVID-19 pandemic? : A case study based on spatial-temporal-semantic analytics

Cities worldwide adopted lockdown policies in response to the outbreak of coronavirus disease 2019 (COVID-19), significantly influencing people's travel behavior. In particular, micro-mobility, an emerging mode of urban transport, is profoundly shaped by this crisis. However, there is limited research devoted to understanding the rapidly evolving trip patterns of micro-mobility in response to COVI

Is it a revolution or a coup? : Scandinavian media representations of the ousting of Egyptian President Mohamed Morsy

In the summer of 2013, millions of Egyptians returned to Tahrir square in Cairo to demand the resignation of the country’s first democratically elected president. This article examines the two key terms mainly used to describe the ousting of President Mohamed Morsy, ‘coup’ and ‘revolution’, and how these terms can be understood as arguments for two different interpretations of the event. Particula

Improvement of structural efficiency in metals by the control of topological arrangements in ultrafine and coarse grains

Improvement of structural efficiency in various materials is critically important for sustainable society development and the efficient use of natural resources. Recently, a lot of attention in science and engineering has been attracted to heterogeneous-structure materials because of high structural efficiency. However, strategies for the efficient design of heterogenous structures are still in th