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Selective ERα modulator, tamoxifen, is well tolerated in a heavily pretreated castration-resistant prostate cancer (PCa) patient cohort. However, its targeted gene network and whether expression of intratumor ERα due to androgen deprivation therapy (ADT) may play a role in PCa progression is unknown. In this study, we examined the inhibitory effect of tamoxifen on castration-resistant PCa in vitro

Methane emissions from boreal and arctic wetlands, lakes, and rivers are expected to increase in response to warming and associated permafrost thaw. However, the lack of appropriate land cover datasets for scaling field-measured methane emissions to circumpolar scales has contributed to a large uncertainty for our understanding of present-day and future methane emissions. Here we present the Borea

Objective: The Systemic Lupus International Collaborating Clinics (SLICC) 2012 systemic lupus erythematosus (SLE) classification criteria and the revised American College of Rheumatology (ACR) 1997 criteria are list based, counting each SLE manifestation equally. We derived a classification rule based on giving variable weights to the SLICC criteria and compared its performance to the revised ACR

Objective: Opioids have long been prescribed for chronic pain conditions, including osteoarthritis (OA). However, there is little information about their temporal efficacy, or differences in efficacy and safety between opioids with strong versus weak/intermediate μ opioid receptor–binding affinity. To explore these research questions, we conducted a systematic review and meta-analyses of randomize

Objective: To explore whether magnetic resonance imaging (MRI) features suggestive of knee osteoarthritis (OA) are associated with presence of knee pain in possible early-stage OA development. Methods: We included 294 participants from the Osteoarthritis Initiative (mean ± SD age 50 ± 3 years; 50% women) with baseline Kellgren/Lawrence grade of 0 in both knees, all of whom had received knee MRIs a

Objective: To assess the proportion of participants reconsidering their willingness to undergo surgery after 3 and 12 months. Secondary aims were to analyze and compare the characteristics of individuals willing and unwilling to undergo joint surgery for osteoarthritis (OA) before a first-line intervention, and to study the association between pain intensity, walking difficulties, self-efficacy, a

In 2019, the Swedish government officially switched terminology from using the traditional endogenous term Vitryssland to the exogenous Belarus. Vitryssland (lit: White Russia) had been in use in the Swedish language since the 17th century, and the decision was neither easy nor swift. There was no consensus about the utility of the change, and significant opposition from linguists and editors agai

Energy users who don’t participate in efficiency and conservation programmes despite ongoing outreach are often referred to as ‘Hard-to-Reach’ (HTR). These individuals or organisations can include, e.g., low income or vulnerable households; renters; and small businesses. More effectively engaging HTR audiences is key to ensuring everyone benefits equitably from low-carbon energy transitions and re

In active volcanic regions, high-temperature chemical reactions in the hydrothermal system consume CO2 sourced from magma or from the deep crust, whereas reactions with silicates at shallow depths mainly consume atmospheric CO2. Numerous studies have quantified the load of dissolved solids in rivers that drain volcanic regions to determine chemical weathering rates and atmospheric CO2 consumption

An comprovisation on the concrete/visual poem "Meditation no. 1" by Emmett Williams.

An comprovisation on the concrete/visual poem "Frictional (Phonetical Etude no. 2" by Jaap Blonk.

PulLingBils, a comprovisation focused on airflow.

An comprovisation on Criptomelodie infantili by Demetrio Stratos.

A comprovisation exploring the switching between ingressive and egressive airflow.

An full concert including the following comprovisations: ABC, Frictional, PulLingBils, Criptomelodie, Crazy gambling witch doctor, and others.

Follow-up rates reported among longitudinal studies that focus on runaway adolescents and their families are relatively low. Identifying factors associated with follow-up completion might be useful for improving follow-up rates and therefore study validity. The present study explored how individual- and family-level constructs, as well as research project activities, influence the follow-up comple

Internet self-efficacy is a pivotal construct for understanding a wide range of online activities. Human activity has been developing in new directions along with the evolution of the Internet over the last few decades. A self-efficacy measure which might appropriately reflect these changes is still lacking in the literature. To address this research gap, the current study developed the Internet S

Homeless youth are a vulnerable and understudied group who hasconsistently reported elevated levels of substance use. Understanding the factors associated with substance use within this population may help guide future intervention efforts. Although few studies have examined the role of abstinence self-efficacy and coping in substance use among homeless youth, some research indicates that higher a

This paper examined the effects of a blogging centered curriculum on the development of Internet self-efficacy of students taking a general education class. The class used a hybrid model (in class and online) that both integrated and strongly encouraged blogging on a community style, open source blog. The curriculum was designed to both create a more distributed educational structure and to develo