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A minimalistic all-atom approach to protein folding

Using simple sequence-based potentials, the folding properties of a designed three-helix-bundle protein, an alpha-helix and a beta-hairpin are studied. The three-helix-bundle protein is modelled using 5-6 atoms per amino acid and is found to undergo a first-order-like folding transition in which chain collapse and helix formation cannot be separated, which is in-accord with experimental data. The

The Invisible Landscapes : The Construction of New Subjectivities in the Era of the Mobile Telephone

The interventions of portable digital devices such as mobile telephones, mp3 players, PDAs and many others, have contributed to the formation of contemporary notions of space. The impact of these devices' mobility (informing the users' mobility) could even be paralleled to the shift from the effects of still photography to those of film in the 19th century. Especially important for the perspective

Suppression of binding events via external perturbation with emphasis on QCM

Recent experiments indicate that the external perturbations, related e.g. to high-amplitude shear oscillations of the surface of a quartz crystal microbalance sensor, may suppress binding of mesoscopic aggregates (e.g., polystyrene spheres, vesicles, large proteins, etc.) to the surface. Using a simple kinetic model, we derive equations making it possible to conceptually understand and to mathemat

The predictive value of albuminuria for cardiovascular and renal disease. A 5-year follow-up study of 476 patients with type I diabetes mellitus

A 5-year follow-up study of 476 type I adult diabetic patients previously studied cross sectionally revealed that, during the observation period, 19 patients died and 30 developed cardiovascular or renal disease, such as myocardial infarction (n = 8), cerebrovascular disease (n = 3), amputation (n = 6), and renal insufficiency (n = 13). The patients were registered by one and the most-severe event

MYB oncogene amplification in hereditary BRCA1 breast cancer

Comparative genomic hybridization analysis has demonstrated that breast tumors from BRCA1 and BRCA2 germ-line mutation carriers contain a large number of chromosomal copy number gains and losses. A high regional copy number gain at 6q22-q24 was observed in one BRCA1 tumor, and fluorescence in situ hybridization analysis indicated a strong amplification of the MYB oncogene (15 copies of MYB compare

Ketamine and midazolam decrease cerebral blood flow and consequently their own rate of transport to the brain: an application of mass balance pharmacokinetics with a changing regional blood flow

Mass balance pharmacokinetics, with simultaneous blood sampling from an artery and the internal jugular vein, was used to characterize the cerebral uptake of ketamine, norketamine, and midazolam in normoventilated pigs. Intravenous injections of ketamine or midazolam decreased the cerebral blood flow (CBF) by one third, as measured by intermittent 133Xe washout. By means of pharmacodynamic models,

PACSIN 1 forms tetramers via its N-terminal F-BAR domain

The ability of protein kinase C and casein kinase 2 substrate in neurons (PACSIN)/syndapin proteins to self-polymerize is crucial for the simultaneous interactions with more than one Src homology 3 domain-binding partner or with lipid membranes. The assembly of this network has profound effects on the neural Wiskott-Aldrich syndrome protein-mediated attachment of the actin polymerization machinery

Biostatistik inom Vårdvetenskap - möjligheter och problem

"You can prove anything with statistics" is a well-known expression, and this might be true if the methods are not properly used and/or the results are not reviewed critically. This demands knowledge about statistical methodology and practice in critically analysis. However, it is not only the researcher that needs this kind of knowledge but also professionals in clinical practice who will be info

On channel estimation in OFDM systems

The use of multi-amplitude signaling schemes in wireless OFDM systems requires the tracking of the fading radio channel. The paper addresses channel estimation based on time-domain channel statistics. Using a general model for a slowly fading channel, the authors present the MMSE and LS estimators and a method for modifications compromising between complexity and performance. The symbol error rate

Investigation of peat pyrolysis under inert gas atmosphere

Seven Swedish peats of different degrees of humification were pyrolysed in a thermobalance at pressures in the range 1.0-4.0 MPa. The formation kinetics of the pyrolysis products were determined using the non-isothermal evaluation method. The sample size used was 1.0 g and the heating rate was 10 K min-1. Gas production was analysed by gas chromatography and the components were CO2, C2H4, C2H6, CH

Ground-state energy of pionic hydrogen to one loop

We investigate the ground-state energy of the pi(-)p atom (pionic hydrogen) in the framework of QCD + QED. In particular, we evaluate the strong energy-level shift. We perform the calculation at next-to-leading order in the low-energy expansion in the framework of the relevant effective field theory. The result provides a relation between the strong energy shift and the pion-nucleon S-wave scatter

Body mass index and risk of malignant lymphoma in Scandinavian men and women

Background. The incidence of non-Hodgkin lymphoma and prevalence of obesity are increasing globally. A suggested positive association between obesity and risk of non-Hodgkin lymphoma has prompted us to investigate the relationship between body mass index (BMI) and risk of malignant lymphoma subtypes in a population-based case-control study. Methods: Telephone interviews were conducted with 3055 ca

Consecutive Desulphurization of Coal with T. ferrooxidans and Acidianus brierleyi

hree different types of bituminous coal were subjected to microbial desulphurization in bench scale slurry reactors. Consecutive treatment with two microorganism species was used to test if different sulphur forms could be removed. The treatment started with the bacterium Thiobacillus ferrooxidans followed by the archaeon Acidianus brierleyi. Consecutive treatment did not desulphurize the three te