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A GUMS procedure was developed for the analysis of all major constituents of glycoproteins. The rationale for this approach is that by using GC/MS analysis of the constituents as heptafluorobutyrate derivatives, it was possible to quantitatively determine the sialic acid, monosaccharide, fatty acids (when present), and the amino acid composition with the sample remaining in the same reaction vesse
Objective - We explored the relationships between inflammatory proteins, occupation, and marital status, and their independent associations with incidence of cardiovascular disease ( CVD). Methods and Results - Five inflammation-sensitive proteins ( ISPs) ( fibrinogen, ceruloplasmin, haptoglobin, alpha 1-antitrypsin, orosomucoid) were measured in 6075 apparently healthy men. Incidence of coronary
Objective: In patients with type 2 diabetes mellitus (T2DM), biomarkers reflecting inflammation and endothelial dysfunction have been linked to cardiovascular disease (CVD biomarkers) and metabolic regulation. In T2DM patients, metformin and insulin secretagogues have demonstrated equal anti-hyperglycaemic potency. Here, we report the effect of metformin versus an insulin secretagogue, repaglinide
Laser-induced fluorescence is a technique for optical tissue characterisation. It has a real-time capability and as the excitation light and the fluorescence emission are transmitted through optical fibres the technique is compatible to various kinds of endoscopes for hollow organ investigation. The tissue fluorescence itself with the emission from the endogenous chromophores or enhanced with exog
The effect of burning piles of slash on a Norway spruce clear-cut in southern Sweden was followed for 3 years. The vegetation cover, soil chemistry, soil water at a depth of 30 - 40 cm and runoff water were studied. The burnt plots were without vegetation for several months after burning, while the control plots were almost totally covered by Deschampsia flexuosa and Galium saxatile. The remaining
Chromosomal aberrations in solid tumors appear in complex patterns. It is important to understand how these patterns develop, the dynamics of the process, the temporal or even causal order between aberrations, and the involved pathways. Here we present network models for chromosomal aberrations and algorithms for training models based on observed data. Our models are generative probabilistic model
Background: Patients with hypertrophic cardiomyopathy (HCM) have a high incidence of atrial fibrillation. They also have a longer P-wave duration than healthy controls, indicating conduction alterations. Previous studies have demonstrated orthogonal P-wave morphology alterations in patients with paroxysmal atrial fibrillation. In the present study, the P-wave morphology of patients with HCM was co
Four adenosine receptor subtypes of the family of G protein-coupled receptors, designated A1, A2A, A2B and A3 are currently known. In this study all human subtypes were stably transfected into Chinese hamster ovary (CHO) cells in order to be able to study their pharmacological profile in an identical cellular background utilizing radioligand binding studies (A1, A2A, A3) or adenylyl cyclase activi
Many cross-border regions in Europe remain more political dreamscapes than examples of strong transnational integration.The development of the Öresund region through a bridge linking Copenhagen and eastern Denmark with Southern Sweden has been seen as a model for EU region building. Drawing on a multidisciplinary project, this article uses the Öresund case as a starting point, bringing in some con
This paper treats four saxicolous species of Caloplaca occurring mainly in subtropical or semiarid regions in North and Central America, C. baueri, C. cinnabarina, C. rosei, and C. rubelliana. These species are mainly characterized by 1) a continuous to cracked areolate thallus, 2) thallus without marginal lobes, 3) areole margins broadly attached to the substrate, 4) cortex distinctly paraplecten
We have used microarray gene expression pro. ling and machine learning to predict the presence of BRAF mutations in a panel of 61 melanoma cell lines. The BRAF gene was found to be mutated in 42 samples (69%) and intragenic mutations of the NRAS gene were detected in seven samples (11%). No cell line carried mutations of both genes. Using support vector machines, we have built a classifier that di
Analysis of high-frequency QRS components (HF-QRS) might provide an additional method when diagnosing various heart diseases, for example ischemic heart disease (HID). This study compares HF-QRS in normal Subjects to those in patients with HID, and also analyzes HF-QRS considering gender and age. A total of 63 normal subjects and 64 patients with IHD were included. Signal-averaged electrocardiogra
Partially ecologic case-control studies combine group-level exposure data with individual-level data on disease status, group membership, and covariates. If the exposure measure is the exposure prevalence of various groups, the attributable fraction (AF; the estimated proportion of cases that are attributable to exposure) can be estimated by classifying all subjects in groups with exposure prevale
New palaeomagnetic data from the autochthonous Early Cambrian Dividal Group (northern Scandinavia) confirm earlier findings, and a refined palaeomagnetic pole of 58.4degreesN and 122.5degreesE, places Baltica at intermediate southerly latitudes at similar to535 Ma. Palaeomagnetic data from the immediately underlying granitic basement (pole: 9.8degreesN, 226.7degreesE) differ markedly from the Divi
Hyperlipidemia appears to play an integral role in loss of glucose-stimulated insulin secretion (GSIS) in type 2 diabetes. This impairment can be simulated in vitro by chronic culture of 832/13 insulinoma cells with high concentrations of free fatty acids, or by study of lipid-laden islets from Zucker diabetic fatty rats. Here we show that impaired GSIS is not a simple result of saturation of lipi
