Sökresultat

Filtyp

Din sökning på "*" gav 534580 sökträffar

Jugoslaviens undergång : Krigen, freden, framtiden. 1991-2017

Det var ett yrvaket och oförstående Europa som från och med 1991 såg konflikterna i Jugoslavien blossa upp i den egna europeiska ”bakgården”. Successivt under hela 1990-talet utvecklades upplösningskonflikten till en rad olika krig, och inte nog med att detta; stridigheterna uppfattades dessutom som ovanligt våldsamma, råa och obegripliga. Framför allt västerländska journalister, universitetsakade

Helping Hand grasp rehabilitation : Preliminary assessment on chronic stroke patients

The Helping Hand (HH) system is a novel grasp rehabilitation platform aimed at simplifying the clinical usage of wearable electrode arrays for neuromuscular electrical stimulation (NMES). In a randomized dose-matched, clinical study we evaluate usability and effectiveness of the HH treatment, and of other enriched upper limb rehabilitation treatments, and compare the outcomes. This paper shows the

IL-1β mediates lung neutrophilia and IL-33 expression in a mouse model of viral-induced asthma exacerbation

BACKGROUND: Viral-induced asthma exacerbations, which exhibit both Th1-type neutrophilia and Th2-type inflammation, associate with secretion of Interleukin (IL)-1β. IL-1β induces neutrophilic inflammation. It may also increase Th2-type cytokine expression. We hypothesised that IL-1β is causally involved in both Th1 and Th2 features of asthma exacerbations. This hypothesis is tested in our mouse mo

House dust mite impairs antiviral response in asthma exacerbation models through its effects on TLR3

BACKGROUND: Impaired antiviral interferon expression may be involved in asthma exacerbations commonly caused by rhinovirus infections. Allergy is a known risk factor for viral-induced asthma exacerbation, but little is known whether allergens may affect interferon responses.OBJECTIVE: Our hypothesis is that house dust mite (HDM) impairs viral stimulus-induced antiviral signalling.METHODS: Experime

Longitudinal study of neuropathy, microangiopathy, and autophagy in sural nerve : Implications for diabetic neuropathy

Objectives: The progression and pathophysiology of neuropathy in impaired glucose tolerance (IGT) and type 2 diabetes (T2DM) is poorly understood, especially in relation to autophagy. This study was designed to assess whether the presence of autophagy-related structures was associated with sural nerve fiber pathology, and to investigate if endoneurial capillary pathology could predict the developm

Intake of Energy and Protein is Associated with Overweight Risk at Age 5.5 Years : Results from the Prospective TEDDY Study

Objective: The associations of energy, protein, carbohydrate, and fat intake with weight status up to the age of 5.5 years were prospectively assessed in The Environmental Determinants of Diabetes in the Young (TEDDY) study. Methods: Food record data (over 3 days) and BMI measurements between 0.25 and 5.5 years were available from 5,563 children with an increased genetic risk for type 1 diabetes f

Determining the optimal forensic DNA analysis procedure following investigation of sample quality

Crime scene traces of various types are routinely sent to forensic laboratories for analysis, generally with the aim of addressing questions about the source of the trace. The laboratory may choose to analyse the samples in different ways depending on the type and quality of the sample, the importance of the case and the cost and performance of the available analysis methods. Theoretically well-fo

CRY1/2 Selectively Repress PPARδ and Limit Exercise Capacity

Cellular metabolite balance and mitochondrial function are under circadian control, but the pathways connecting the molecular clock to these functions are unclear. Peroxisome proliferator-activated receptor delta (PPARδ) enables preferential utilization of lipids as fuel during exercise and is a major driver of exercise endurance. We show here that the circadian repressors CRY1 and CRY2 function a

Comparison between normal saline and Ringer’s acetate in bipolar transurethral resection of the prostate

Objective: The standard surgical treatment for benign prostatic hypertrophy (BPH) is transurethral resection of the prostate (TURP). The aim of this study was to compare normal saline (NS) (0.9% sodium chloride) and Ringer’s acetate (RA) as irrigation fluid with regard to visibility, resection feasibility, coagulation and bleeding in bipolar TURP. Materials and methods: Twenty patients (mean age 7

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans

To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum, we conducted a meta-analysis of genome-wide association data from 26,676 T2D case and 132,532 control subjects of European ancestry after imputation using the 1000 Genomes multiethnic reference panel. Promising association signals were followed up in additional data sets (of 14,545 or 7,397 T2D case an

A spatially explicit agent-based simulation model of a reservoir host of cutaneous leishmaniasis, Rhombomys opimus

Rhombomys opimus (R. opimus), a social rodent, is the main reservoir host for zoonotic cutaneous leishmaniasis (ZCL) in most parts of the Middle East and central Asia. The difficulties in monitoring rodent population patterns have hindered the effective application of preventive measures of ZCL. This study presents a spatially explicit agent-based simulation model of R. opimus behaviors that is in

Microcontact-BSA imprinted capacitive biosensor for real-time, sensitive and selective detection of BSA

An analytical method is presented, combining novel microcontact imprinting technique and capacitive biosensor technology for the detection of BSA. Glass cover slips were used for preparation of protein stamps. The microcontact-BSA imprinted gold electrodes were prepared in the presence of methacrylic acid (MAA) and poly-ethylene glycol dimethacrylate (PEGDMA) as the cross-linker by bringing the pr

Molecularly imprinted supermacroporous cryogels for myoglobin recognition

Myoglobin is a primary iron, and oxygen-binding protein of muscle tissues and levels can be an important diagnostic biomarker for acute myocardial infarction, myocardial necrosis, or other cardiac diseases. The establishment of myoglobin recognition systems is important because of its protein's structural and functional values in physiology, biochemistry, and diagnostic value in some damaged muscl

Molecularly imprinted cryogels for human interferon-alpha purification from human gingival fibroblast culture

Interferons are important proteins for the immune system because of their antiviral, anti-proliferating and immunomodulatory activities. Therapeutic value of these proteins against certain types of tumors caused interest and investigations aimed to obtain highly purified interferons. Molecular imprinting is an efficient method for purification with high selectivity, specificity and good reproducib