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Cellular reprogramming is the process of converting cells from one cell type to another. The ability to generate specific cell types is useful when constructing models of development and disease, and reprogramming could potentially be used for regenerative therapy in the future. However, applications are limited by the low reprogramming efficiency of existing protocols. The goal of this thesis was
Virtual sensors implemented in vehicles enable the prediction of forces experienced during their operational lifetime and thus allow an extension of durability assessment into the operational phase of customer vehicles. Due to limited computational capacity of onboard electronic control units, full-scale deep learning models are often too expensive for real-time operation. As a result, compact ne
In the times of electrification, energy storage becomes increasingly important when incorporating more variable renewable energy production (VRE) into the power system. Combined with large revenues connected to ancillary service markets and cheaper technology, battery energy storage systems (BESS), have sparked an interest amongst investors. The effect is a major increase of BESS connection reques
Cutaneous T-cell lymphoma is a chronic disease with a highly heterogeneous and unpre-dictable clinical course, and the impact on psychological resilience is still unknown. The primary aim was to investigate psychological resilience in cutaneous T-cell lymphoma patients over time and to relate it to dermatology-related quality of life (QoL) metrics. Psychological investigations were evaluated in 45
PURPOSE: To determine whether Comprehensive Geriatric Assessment (CGA)-based healthcare, delivered by a mobile team over 24 months in patients' homes reduces hospital care or improves quality of life, physical performance, frailty, activities of daily living (ADL), or cognition and whether it reduces mortality or number of hospital admissions.METHODS: Patients ≥ 75 years of age, with ≥ 3 visits to
BackgroundThe Parkinson's Disease (PD) Home Diary (HD) is a common clinical outcome measure, but studies show only fair agreement between clinical observer and patient assessments, with no significant improvement after patient training.ObjectivesTo investigate the agreement between a clinical observer and relatives of PD patients when assessing the patient's motor status in the HD. Agreement was a
During the recent decades, through the emerging of pump-based Parkinson (PD) therapies, it has been increasingly possible to manage motor fluctuations and dyskinesias, providing a stable levodopa plasma concentration. This can be carried out by continuous delivery of levodopa-carbidopa intestinal gel (LCIG) or levodopa-entacapone-carbidopa intestinal gel (LECIG) via a percutaneous endoscopic gastr
The coupling between sleep-awake and dark-light cycles has played an important role in understanding external and internal biological clocks. However, how functional patterns of brain regions involved in these two coupled cycles deteriorate from circadian rhythm disturbance to circadian rhythm sleep disorder remains largely unexplored in neuroimaging research. In this study, we built a whole-brain
To effectively treat motor fluctuations and dyskinesia in advanced Parkinson's disease (PD), intestinal levodopa therapy can be carried out by continuous delivery of levodopa-carbidopa intestinal gel (LCIG; Duodopa®). LCIG is delivered with a portable pump system over tubing, entering the stomach through a percutaneous endoscopic gastrojejunostomy (PEG-J) and continuing to the proximal part of the
Triacylglycerol (TAG) serves as the primary storage lipid in plants, essential for seed germination and early seedling development. Acyl-CoA:diacylglycerol acyltransferase (DGAT) enzymes catalyze the last step in TAG synthesis by converting diacylglycerol (DAG) to TAG. Although functionally conserved across species, DGATs exhibit variations in substrate preference, among their other properties, hi
With the expected further electrification of society, a greater electricity demand is to be expected, requiring improved flexibility. One proposal that meets these demands is the adaptation of the current district heating power plants by adding condensing tail turbines. Condensing tail turbines allow for further expansion of steam. A simple economic analysis showed that implementing a condensing t
The X-ray solution scattering from water S(Q)H2O depends on temperature and density, a phenomenon that is utilized in, for example, temperature-resolved and ultrafast time-resolved X-ray solution scattering experiments. Whether this contribution to the acquired data arising from changes in scattering from water is merely a background signal to be subtracted or the primary subject of investigation,
Study region: The Missouri River Basin, located between the states of Nebraska and Iowa, USA. Study focus: Water level (WL) and discharge (Q) are key hydrological variables, accurate prediction of which in both long-term and short-term (extreme events) scenarios is essential for water resources and flood risk management. We propose a novel hybrid deep learning architecture, CNN-NLSTM-SA, which int
Quantum measurements under realistic conditions reveal only partial information about a system. Yet, by performing sequential measurements on the same system, additional information can be accessed. We investigate this problem in the context of semi-device-independent randomness certification using sequential maximum-confidence measurements. We develop a general framework and versatile numerical m
Rotation is a natural tool in ultracold gases to break time-reversal symmetry, yet its impact on the collective excitations of supersolids remains largely unexplored. We show theoretically that tuning the rotation frequency, rather than the interparticle interactions, can trigger the superfluid-to-supersolid transition in Bose-Einstein condensates. Computing excitation spectra in the presence of v
According to defenders of the popular buck-passing account of value (the BPA of value), values should be understood in terms of reasons for pro- and con-responses. While much has been said about how to understand the normative component of the BPA of value, that is, how to understand ‘reasons’, including how to distinguish between reasons that imply value (the ‘right’ kind of reasons) and those th
Previous research underscores the importance of addressing biodiversity loss within environmental justice, introducing the concept of multi-species justice (MSJ) to recognise the rights and agency of non-human species. Despite its theoretical foundation, practical applications of MSJ remain underexplored. This paper contributes to operationalising MSJ in climate adaptation by exploring barriers to
Background: Ensuring that national governance and healthcare systems include the organization and provision of palliative care in all care settings for all patients in need is a global imperative. In cancer care, early palliative care can improve quality of life for patients and families and receiving specialised palliative care increases opportunities for care and death in the preferred place, wh
Psoriasiform eruptions have been described in patients treated with dupilumab. This case report describes an adolescent with severe atopic dermatitis who developed a widespread psoriasiform dermatitis 8 months after starting dupilumab. His therapy was switched to abrocitinib resulting in near-complete resolution of the psoriatic lesions with good atopic dermatitis control. This case adds to the li
Regional carbon dioxide (CO₂) and methane (CH₄) source contributions were analysed at two European coastal observatories, El Arenosillo (ARN) in southwestern Spain and Capo Granitola (CGR) in southern Italy, using in situ observations and STILT model simulations from 2006 to 2023, enabling source attribution to biogenic, fossil fuel, anthropogenic, and natural contributions. Model-observation agre
