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BACKGROUND: Air pollution is a major public health concern, contributing to cardiovascular and respiratory diseases. One of the main pathways by which air pollution affects cardiovascular health is through dysregulation of the autonomic nervous system (ANS), which impairs cardiac control. Hydrotreated vegetable oil (HVO) is a renewable fuel with unknown toxicity in comparison to conventional diese
Graphical methods for system analysis have played a central role in control theory. The Scaled Relative Graph (SRG) has recently emerged as a useful tool for stability analysis of feedback interconnections. In this letter, we further extend its applicability by showing how the SRG of a discrete-time linear-time-invariant (LTI) system can be computed exactly from its state-space representation usin
In diesem essential werden die aktuellen Probleme der Agenda 2030 zur Umsetzung der Nachhaltigkeitsziele im Bereich Gesundheit erläutert. Das weltweite Aufkommen von Zivilisationskrankheiten und die explodierenden Kosten in der medizinischen Versorgung stellen die Weltgemeinschaft in Zeiten von Corona und Krieg vor große Herausforderungen. Um einen weiteren Rückschritt in der globalen Gesundheitsv
Die Agenda 2030 hat sich zum Ziel gesetzt, eine Welt ohne Armut, Hunger und Krankheit zu schaffen und dafür zu sorgen, dass jeder Mensch ein Leben frei von Furcht und ohne Unterdrückung führen kann. Um dies zu erreichen, muss jeder Mensch auch ein Recht auf Bildung haben. Ganzheitliche Bildungskonzepte sind hierbei von großer Bedeutung, da mit ihnen ein Umdenken zu einer nachhaltigen Lebensweise i
In der Geschichte der Menschheit haben Seuchen und Plagen immer wieder eine Spur von Leid und Tod hinterlassen. Auch in der Zukunft werden wir nicht von Pandemien, die über uns hereinbrechen werden, verschont bleiben. Der Ausbruch von COVID-19 kann daher auch als der Beginn einer neuen Bedrohung, die von lebensgefährlichen Infektionskrankheiten ausgeht, angesehen werden. Ursache hierfür sind unter
Introduction: Malignant hyperthermia (MH) is a pharmacogenetic, hypermetabolic and potentially lethal reaction to potent volatile anaesthetics and the muscle relaxant succinylcholine. To improve the understanding of MH, the aim of this retrospective study was to describe the Swedish cohort with respect to clinical manifestations, demographics and genetic findings. Method: The Swedish MH Registry c
Proteoglycans with their attached negatively charged glycosaminoglycans (GAGs) play a crucial role in proper tissue morphology and function throughout the body. Their complex meshwork exists either as thin sheet-like basement membranes lining epithelial cells as in airway bronchial and alveolar epithelial tissue or as a meshwork-like interstitial extracellular matrix (ECM) that forms porous three-
Smooth muscle cell–related transcription factors have been associated with coronary artery disease in large genome-wide association studies, increasing their translational value for therapeutic investigations. Our study shows for the first time that FOXC1 is a major transcriptional regulator in vascular injury and atherosclerotic lesions, causally implicated in the disease. Functionally, our data
With climate change and urbanisation increasing wildfire risk in the wildland–urban interface (WUI), enhancing community evacuation preparedness is crucial. This study evaluates different data collection methods for measuring traffic flows during a community wildfire evacuation drill in Roxborough Park, Colorado, in June 2024. A multi-method strategy was applied, including drone footage, human obs
The development of longitudinal diagnostics for short-pulse electron accelerators is challenging but necessary to provide high-brightness electron bunches. This is equally true in novel plasma accelerators and for free electron lasers. The gold standard for such measurements is the transverse deflecting cavity (TDC); however, these devices are typically invasive and costly to produce and operate.
Agroforestry systems – combining trees with crops and/or livestock – are increasingly promoted as sustainable and climate-resilient land-use strategies. Despite their widespread presence in the Sahel, experimental data on their potential as carbon sinks are scarce. This study presents a full-year, high-frequency dataset of CO2 fluxes in a Sahelian agro-silvo-pastoral parkland dominated by Faidherb
During land model development, simulated carbon dynamics are often benchmarked against observational data sets to evaluate model performance. Functional relationship benchmarks are the relationship between a driving variable (e.g., temperature) and a response variable (e.g., ecosystem respiration) and are a promising tool for assessing model performance by evaluating modeled sensitivities to chang
The paper relates to the use of Generative Artificial Intelligence in software engineering practice. The nature of Generative Artificial Intelligence is introduced. Drawing upon the literature of the field, the positive benefits of AI use are considered and discussed in relation to some of the drawbacks and challenges involved. The discussion then moves on to examine the views of professionals, as
Educational drama is a proven method for anti-bullying education, but its traditional reliance on teachers and peers limits its accessibility to children and families outside of school. HCI has rarely explored how to augment this practice with AI-infused, interactive role-playing or how to involve parents in the process. We introduce DOLLama, an AI-powered projection-augmented interactive system t
Alternative Food Networks are an important reaction to the global food system, and an abundant literature already debates the nature and significance of these different ways of organizing the production and exchange of food. Much of this discussion pivots around whether AFNs offer an alternative to how the food system is organised by the market. Nonetheless, the very notion of what it means for an
Introduction Breathlessness limits exercise training intensity in people with chronic lung disease (CLD). Stimulation of the trigeminal nerve via fan-to-face (F2F) therapy (facial airflow) can reduce exertional breathlessness and improve exercise endurance in CLD. This randomised controlled trial tested the hypothesis that adding F2F therapy to an exercise training programme could enhance the bene
Nutritional ecology is a key determinant of bee health, yet species-specific preferences and how bees respond nutritionally to real-world pesticide exposure remain unclear. We collected pollen stores from three managed bee species in 128 sites across two widespread agro-ecosystems (i.e., oilseed rape fields and apple orchards) in eight European countries. We measured protein content, lipid content
Oligomers are transient toxic species in amyloidoses such as Alzheimer's disease. The binding of oligomers by human chaperone proteins has been inferred from the lack of detectable interactions with monomeric amyloid proteins and delay of fibril formation at sub-stoichiometric chaperone to monomer molar ratios. In this study, we provide direct experimental evidence for the binding of the human cha
The Large Magellanic Cloud (LMC) and Small Magellanic Cloud (SMC) are the Milky Way’s nearest interacting galaxy pair, offering a unique laboratory for studying tidal effects on galactic disks. Despite extensive survey efforts, the 3D geometry of the Magellanic Clouds, particularly the putative warp of the LMC, remains poorly constrained due to incompleteness in their crowded centers and the low s
