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Many patients with asthma or chronic obstructive pulmonary disease (COPD) routinely receive a combination of an inhaled bronchodilator and anti-inflammatory glucocorticosteroid, but those with severe disease often respond poorly to these classes of drug. We assessed the efficacy and safety of a novel inhaled dual phosphodiesterase 3 (PDE3) and PDE4 inhibitor, RPL554 for its ability to act as a bro
In recent years the development and use of crash prediction models for roadway safety analyses have received substantial attention. These models, also known as safety performance functions (SPFs), relate the expected crash frequency of roadway elements (intersections, road segments, on-ramps) to traffic volumes and other geometric and operational characteristics. A commonly practiced approach for
This article takes the work of David Harvey as an example of the valuable research being done in the space between geography and history. Harvey's influence is described as being significant in the canonical debates within geography that have had a far-reaching impact outside that particular field. His production is summarized from three different perspectives. First, his contribution to the theor
Genetic predisposition for cardiovascular disease (CVD) is likely to be modified by environmental exposures. We tested if the associated risk of CVD and CVD-mortality by the single nucleotide polymorphism rs4977574 on chromosome 9p21 is modified by life-style factors.
Breast cancer expression profiling has been used for determining biomarkers. Using gene expression profiles of 2,400 patients we identified keratin 19 (KRT19) as a highly deregulated gene in breast cancer. KRT19 expression is independent of patient race but correlates with disease grade, and ER, PR or HER2 expression. Expression of TPD52, GATA3 and KRT18 was increased in KRT19 expressing patients.
Predictions of high-energy hadron activation of liquid argon in the calorimeter of A Thoroidal LHC ApparatuS (ATLAS) were carried out by folding particle flux spectra with the radionuclide production cross sections. Calculations were performed with a wide array of input data. Six sets of cross sections were folded with two sets of particle flux spectra, and the results were compared. The particle
This dissertation aims to contribute to the study of the relationship between religion and politics and especially research about Islam and Muslims in Sweden. The thesis analyzes how Islam and Muslims are depicted in Swedish public policy debates between 1975–2010. The research questions are: How are Islam and Muslims described in Swedish public policy? Which questions and in what circumstances ar
The critical levels for ozone effects on vegetation have been reviewed and revised by the LRTAP Convention. Eight new or revised critical levels based on the accumulated stomatal flux of ozone (POD gamma, the Phytotoxic Ozone Dose above a threshold flux of Y nmol m(-2) PLA s(-1), where PLA is the projected leaf area) have been agreed. For each receptor, data were combined from experiments conducte
Popular Abstract in English Labour is said to be obstructed when the baby’s presenting part fails to descend through the birth canal despite strong uterine contractions. Obstructed labour is one of the major causes of maternal and neonatal mortality and morbidity in low-income countries. It is mostly caused by disproportion between the baby’s head and mother’s pelvis but also abnormal presentationLabour is said to be obstructed when the presenting part fails to descend through the birth canal despite strong uterine contractions. The condition is mostly prevalent in low-income countries where the main causes are cephalopelvic disproportion and malpresentation. The overall aim of this thesis was to investigate the individual, community and health system factors associated with obstructed lab
Here, we describe the development of seven new microsatellite loci from Petaurus breviceps. Together with eight loci from previous studies of gliders, we tested their utility for amplification, multiplexing and polymorphism in two glider species, P. breviceps and P. norfolcensis. Of the 15 loci tested, all were polymorphic in P. breviceps and 12 were polymorphic in P. norfolcensis. Overall, 260 su
Medical X-ray imaging is the largest source of radiation exposure to the population from artificial sources. Computed tomography (CT) contributes with 50-80 % of that radiation. About 660 000 CT examinations (2005) are done in Sweden every year. A CT examination gives a mean effective dose of 5 mSv, which is about 10 times higher than for a corresponding conventional X-ray investigation. This pres
The effect on a model drug delivery system when adding a drug, lidocaine, has been studied. Temperature and concentration dependence of a nonionic microemulsion with part of the oil, 1 and 10 vol. %, substituted with drug has been investigated. A nonionic oil-in-water microemulsion consisting of CH3(CH2)(11)(OCH2CH2)(5)OH, (C12E5), decane, water and the drug (lidocaine) that has been used to subst
This review focuses on what has been learned about the evolution of photosynthesis in the past five years, and omits evolution of CO2 assimilation. Oxygenic photosynthesis (using both photosystems I and II) has evolved from anoxygenic photosynthesis. The latter occurs in different variants, using either a type 1 photosystem resembling photosystem I, or a type 2 photosystem resembling photosystem I
In adult mammals, neural stem cells (NSCs) are found in two niches of the brain; the subventricular zone by the lateral ventricles and the subgranular zone of the dentate gyrus in the hippocampus. Neurogenesis is a complex process that is tightly controlled on a molecular level. Recently, microRNAs (miRNAs) have been implicated to play a central role in the regulation of NCSs. miRNAs are small, en
