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Cancer progression is profoundly influenced by the dynamic interactions between cancer cells and their surrounding tumour microenvironment (TME). A defining feature of the TME is the progressive remodelling of the extracellular matrix (ECM), which becomes stiffer and structurally altered during disease progression. These changes regulate cell behaviour and contribute to tumour growth, invasion and
Urfolks- och lokal kunskap (ULK) erkänns alltmer för sin betydelse inom miljöförvaltning. Trots detta saknar mycket forskning om tropiska skogsdjur ofta inkludering av urfolks epistemologier. Mitt examensarbete tar itu med det jag kallar för 'Inkluderings-Deltagande-Dialog-Produktionsgapet' genom fyra år av delaktighetsbaserad handlingsforskning (DHF) med två urfolksgemenskaper i den colombianska Indigenous and Local Knowledge (ILK) is increasingly recognised for its importance in environmental governance. However, despite this recognition, most research on tropical forest fauna lacks the inclusion of Indigenous epistemologies. My thesis addresses what I refer to as the Inclusion Participation-Dialogue-Coproduction Gap through four years of Participatory Action Research (PAR) with two Indi
Vid International Law Associations 82:a internationella konferens i Wien 2026-08-17—21 redovisade kommittén om de rättsliga aspekterna av rymdskrotsanering sitt första arbetsår. Rymdskrot är ett växande hot mot de satellittjänster som bär navigation, telekommunikation, jordobservation, katastrofhantering, finanssystem och försvar. Men teknisk förmåga att gripa, stabilisera eller flytta ett uttjäntAt the International Law Association’s 82nd Biennial International Conference in Vienna on August 17–21, 2026, the ILA Committee on the Legal Aspects of Space Debris Removal presented a report on its first year of work. Space debris poses a growing threat to satellite services that support navigation, telecommunications, Earth observation, disaster management, financial systems, and defense. Howev
Adult patients with inherited metabolic diseases are often overlooked. Limited data on this population hinder adequate planning of their clinical and social care. In this retrospective, observational, cross-sectional service evaluation study, we reviewed the electronic medical records of adult patients with inherited neurometabolic diseases (NIMD) managed at Skåne University Hospital between 2020
Molecular design combining biobased feedstocks, fiber processability, and reversible crosslinking is important for sustainable textiles. Herein, we report a new molecular design and synthetic strategy for partially biobased polyurethanes with tuneable chemical composition and properties, which show potential for the development of reversibly crosslinked textile fibers with enhanced recyclability.
Variation at the 17q21.31 locus, which contains the gene encoding microtubule-associated protein tau (MAPT), has been associated with neurodegenerative disorders, including Parkinson’s disease (PD). This highly complex locus is characterized by two broadly defined haplotypes: H1 and the inverted H2 haplotype. While H1 has been associated with an increased PD risk and is present in all ancestry pop
A prototype of a novel Photoemission Mask type X-ray Beam Position Monitor (PheM XBPM) for the ‘white’ undulator radiation which concept was proposed and has been built and tested. The prototype was designed and manufactured at MAX IV. Two PheM XBPMs were in-stalled at MAX IV 3 GeV storage ring at SoftiMAX and CoSAXS beamline frontends. Signal modelling, optimization and performance results of the
Purpose: Ovarian cancer is the most lethal gynecological malignancy, and chemotherapy strategies have evolved substantially over recent decades. This study aimed to evaluate whether survival outcomes of epithelial ovarian cancer (EOC) have improved over time and to explore trends in younger patients of reproductive age. Basic Procedures: We retrospectively analyzed real-world data from the Tokai O
Introduction: The seventh Åland Island Meeting on von Willebrand Disease (VWD) was held on the Åland archipelago in Finland, from 26 to 28 September 2024. Aim: The meeting brought together experts in the field of VWD from around the world to share the latest advances and knowledge in VWD. Results and Discussion: The topics covered both clinical aspects of management and biochemical and laboratory
Oral streptococci colonize the oral cavity in multispecies communities. They adhere to the salivary pellicle through surface interactions, whereafter additional bacteria and fungi are recruited to form the stable community. The oral streptococci reside as commensals in the oral cavity and contribute to homeostasis, for example, through colonization resistance. However, accumulation of bacteria at
RATIONALE: Information is missing on the tissue cell expression patterns of interleukin 33 (IL-33) and splice variants of the IL-33 receptor ST2 in normal and chronic obstructive pulmonary disease (COPD) lungs.OBJECTIVES: To characterize the expression patterns of IL-33, the soluble ST2 (sST2) and membrane-bound ST2 (ST2L) splice variants in the poorly studied small airway and distal lung compartm
