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Introduction: Doxorubicin (DOX), a potent anthracycline, is widely used in cancer therapy, but its effect is limited by doxorubicin-induced cardiotoxicity (DIC). Increasing evidence suggests that DIC is associated with ferroptosis, a cell death characterized by the iron-dependent accumulation of lipid peroxides. Although aerobic exercise is recommended for chemotherapy-related cardiac dysfunction,
Epilepsy is a prevalent neurological disorder characterized by spontaneous recurrent seizures (SRS). Epileptogenesis is a multifaceted pathophysiological process that transforms a normal brain into one prone to chronic seizures. Targeting epileptogenesis is a compelling line of epilepsy therapy. Thus, discovering new drugs that oppose, mitigate, or modify epileptogenesis is a significant challenge
The life of Jerome of Stridon (d. 419/420), who was regarded as a father of the church and one of the most important authorities in the Middle Ages, has often been depicted as highly controversial: In modern reconstructions, Jerome is typically described as an outsider, constantly involved in controversies and frequently criticized and questioned by his contemporaries. This begs the question of ho
The intervention Balancing Everyday Life™ (BEL) helps service users achieve a balance among everyday activities and enhance personal recovery. BEL builds upon research for people with mental illness and on evidence from earlier activity-based interventions. This methodological paper presents the theoretical basis for BEL, which rests on five pillars of theories and models. Further, the BEL topics
At the heart of P. F. Strawson’s naturalistic approach to responsibility sits the Inescapability Claim. The main argument of this article is that the established interpretation of this claim is mistaken. According to, what I will call, the Standard Reading, it is the empirical claim that it is psychologically impossible for us to abandon our responsibility practices. Although widespread, this read
Context. Differentiating between in situ and accreted populations in the Milky Way halo is a challenging task. Various kinematic spaces are often used to identify distinct accreted populations from the in situ Milky Way halo. However, this approach has limitations, especially at low orbital energies. To overcome this ambiguity, elemental abundances are typically used to distinguish between populat
Ubiquitously used for monitoring pipelines and infrastructures, distributed fibre-optic acoustic sensing is becoming an emerging technology for earthquake monitoring thanks to the possibility to interrogate a large vast of distances with a dense number of sensing points in which an optical fiber cable can be retrofitted. Moreover, it can also be used as a tool by geophysicists for the characteriza
A fundamentally crucial suggestion to rectify the fits to the high-resolution X-ray photoelectron spectroscopy (XPS) raw data for the S 2p core level published by Dirin et al. (Nano Lett. 2023, 23 (5), 1914–1923) is presented herein.
Cognition in children with cerebral palsy (CP) is often affected. How cognition differs by functional level and subtype is not clear, and the effects of adapted response modes need investigation. In this study, the aims were to investigate how many psychologists reported that interpreters and/or augmentative and alternative communication (AAC) were used, how many assessments were adapted, if there
The faecal contamination of irrigation water threatens public health. Although safe practices can mitigate hygiene and food safety risks along the urban irrigated vegetable value chain, their adoption remains limited. A behaviour framework was combined with a participatory approach to explore how institutions influence stakeholders’ capability, opportunity and motivation to adopt safe practices in
Literature reviewsfrom various countries indicate a difference between calculated and measuredbuilding energy use, often known as the ‘energy performance gap’. This articleexplores the existence and magnitude of the energy performance gap in Swedenand identifies possible reasons behind it. A general evaluation of Swedishbuildings showed a median discrepancy between 10–20%. To explore causes,semi-s
Membrane Technology for Water Purification is a comprehensive guide arranged in three parts to enable the student and researcher learn about membrane technology and the most recent updates of material science to clean water of its pollutants. Membrane systems are finding increasing application worldwide in purification and the editors re lead experts in the field. The book contains real-life appli
Background Bacterial vaginosis (BV) is the most common vaginal infection among women of reproductive age worldwide, caused by dysbiosis of the vaginal microbiome. Despite its prevalence, the underlying molecular mechanisms remain poorly understood, making diagnosis and treatment challenging. Although antibiotics are the standard therapy, recurrence rates are high, up to 50% within 1 year, and repe
Objective: To investigate the validity, reliability, and interpretability of the Danish and Swedish versions of the Bristol Rheumatoid Arthritis Fatigue Multi-Dimensional Questionnaire (BRAF-MDQ) and Bristol Rheumatoid Arthritis Fatigue Numerical Rating Scales (BRAF-NRS V2) (BRAFs) in patients with spondyloarthritis (SpA). Method: The BRAFs were tested for validity and reliability in an online sur
Dissolved organic matter (DOM) is a major source of macronutrients to freshwaters, yet it has variable and poorly understood bioavailability. Because intrinsic variation in bioavailability is caused by chemical structures of organic nutrients, DOM composition data should improve predictions of bioavailable resource pool sizes. We hypothesized that bioavailable organic carbon (C) and nitrogen (N) f
The timing of the spring season in the boreal region is shifting under global warming, with profound impacts on ecosystems and hydrological processes. However, the mechanisms driving this transition and its considerable interannual variability are not well described, especially regarding the influence of large-scale atmospheric teleconnection patterns. This study examines the temporal variability
Despite a flurry of critical analyses discussing its controversial track record in terms of effectiveness and social feasibility, carbon offsetting remains one of the key mechanisms within global climate governance. We address an understudied dimension of the offsetting paradigm, with a focus on the voluntary carbon market and nature-based ‘solutions’, to inquire whether carbon trading constitutes
Internalizing disorders (INTs), including anxiety (AD) and depressive disorders (DD), frequently emerge during adolescence. Studies suggest that certain core domains of executive functioning (EF), i.e. inhibition, shifting and working memory (WM) may show selectively lower performance in certain INTs. This systematic review aimed to evaluate the evidence of associations between INTs and EF in adol
Aims/hypothesis: The aim of this work was to investigate whether baseline uric acid (UA) is associated with future complications among young individuals with newly diagnosed type 1 diabetes. Methods: UA levels were analysed in individuals, aged 15–34 years with newly diagnosed type 1 diabetes, from the nationwide Diabetes Incidence Study in Sweden (DISS) cohort to assess the relationship with macr
Climate warming, nutrient loading, and pesticide pollution are major anthropogenic stressors affecting community dynamics and trophic interactions in aquatic ecosystems. However, the complex interplay among these stressors remains poorly understood as most studies focus on a single stressor and overlook the effects of temporal variations. To address this knowledge gap, we first conducted a long-te
