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Background: Glioblastoma carries a dismal prognosis, with only a small proportion of patients surviving beyond five or ten years. Although the introduction of new oncological therapies has improved median overall survival among treated patients, their impact on long-term survival in population-based cohorts remains unclear. The primary aim of this study was to analyze temporal trends in long-term
Background: Chestwall perforator flaps have been used in breast conservation after wide local excision for more than a decade. Although the technique is promising, it still needs to be standardized. For example, no published studies have numerically proven that the operated breast retains its features after operation and radiation. This study compared preoperative- and 1-year postoperative measure
As deep learning methods become more frequent in medical imaging, model explainability becomes essential in order to ensure trust. Gradient-weighted class activation mapping (Grad-CAM) is a widely used technique for visualizing which regions of an input contribute to a network’s decision. In this work, we introduce a novel Grad-CAM–based loss function that leverages prior knowledge of target regio
We analyze a system of dipolar atoms confined in geometries of quasi low dimensionality. Due to the long-range and anisotropic nature of dipolar interactions, the system supports both stable solitons and quantum droplets. In quasi-one-dimensional geometries, the transition between these states is known to manifest either as a first-order phase transition, associated with bistability, or as a smoot
Background: Basal cell carcinoma (BCC) is the most common skin cancer, and accurate histopathologic risk stratification is essential for treatment selection. Convolutional neural networks (CNNs) demonstrate promise in image analysis, yet few studies have evaluated classification of BCC subtypes. Objective: To assess the diagnostic performance of a CNN for binary classification of high-versus low-r
Dead material zones – stationary regions of adhered material at the tool–workpiece interface – are a recurring feature in large-strain deformation processes such as metal cutting and indentation. Despite their practical significance, the mechanisms governing their initiation and evolution remain poorly understood, largely due to the difficulty of resolving local deformation events in real time. In
Acylcarnitines (ACs) play a pivotal role in metabolism, most notably by facilitating the transport of fatty acids (FAs) into mitochondria for β-oxidation, a key step in cellular energy production. Dysregulation of AC, FA, and amino acid (AA) levels has been linked to various metabolic disorders, including cardiovascular diseases, neurodegenerative conditions, and cancer. Consequently, monitoring t
Individual differences in employees’ affective dispositions influence how they perceive the work environment and report their well-being. A recurring challenge in this literature is that self-reported measures of working conditions and well-being cannot easily distinguish objective environmental features from the perceptual lens through which employees report them. Using a large, stratified sample
Continuous glucose monitors (CGMs) provide detailed glucose profiles, but their relevance to health outcomes in individuals without diabetes remains unclear. Here we assess time in range (TIR3.9–5.6 and TITR3.9-7.8) and glycaemic variability in individuals (N = 3,634; age 46 ± 12 y; 83% female; BMI 27 ± 6 kg/m²) from PREDICT 1 (NCT03479866), PREDICT 2 (NCT03983733), and PREDICT 3 (NCT04735835) wit
Purpose: Secondary brain injury is a common cause of poor outcome after trauma, subarachnoid hemorrhage, and intracerebral hemorrhage, and optimizing treatment requires real-time insight into cerebral metabolism. Cerebral microdialysis (CMD) uniquely provides key related information, yet consensus on its use has not been updated since publication of the consensus statement from the 2014 Internatio
Between 1966 and 1996, French nuclear testing in French Polynesia was justified through a recurring promise/threat nexus that linked strategic necessity to development while producing enduring social and environmental harms. Presidential speeches delivered in Tahiti by Charles de Gaulle, François Mitterrand, and Emmanuel Macron illuminate how the test site and its aftermath have been governed thro
Artificial intelligence (AI) was increasingly used in municipal organisations as part of broader digitalisation and efficiency efforts. The study aimed to examine how unit managers and digitalisation or IT officers described the implementation and use of AI-related tools in social work within the Labour Market Administration and the Health- and Social Care Administration in a large municipality in
Denna studie undersöker hur självorganiserade semi-offentliga mötesplatser på Södermalm i Stockholm påverkas av samtida urbana omvandlingsprocesser, särskilt gentrifiering, samt vilka konsekvenser detta får för deras funktion som sociala och demokratiska rum. Studien utgår från kritisk urban teori och begreppet rätten till staden för att analysera hur ekonomiska och politiska strukturer formar til
I uppsatsen undersöks huruvida ett etablerings- respektive finansieringstopp för konfessionella friskolor kan införas i Sverige med hänsyn till Sveriges åtaganden enligt Europakonventionen. Uppsatsen utgår från ett föräldra- och huvudmannaperspektiv och undersöker genom en rättsdogmatisk metod hur ett etablerings- respektive finansieringsstopp förhåller sig till föräldrarätten enligt artikel 2 i TThis thesis examines whether a ban on the establishment of, or public funding for, denominational independent schools can be introduced in Sweden in light of Sweden's obligations under the European Convention on Human Rights. Adopting the perspectives of both parents and school providers, the thesis employs a legal dogmatic method to examine how a ban on the establishment of, or public funding
This thesis investigates how residents of the Pogranicze region, specifically Hajnówka County in north-eastern Poland, experience and interpret the act of helping migrants crossing the Polish-Belarusian border under conditions of hybrid war. Starting in 2021, the region has become the site of a humanitarian crisis, as the Belarusian state has instrumentalised migration as a geopolitical weapon, to
This thesis explores how music students and aspiring cultural and creative workers from Southern Italy perceive and negotiate Italian regional inequalities through educational mobility towards Centre-Northern regions. The aim of the present study is to delve deeply into the ways Italian regional disparities shape students’ decisions to move, their experiences within music higher education and thei
This thesis examines the strategic trade-off between internal innovation and external capability acquisition in the software sector. Software firms operate in markets where innovation speed, scalability, and product-market timing are central to competitiveness, making the choice between developing capabilities internally and acquiring them externally particularly relevant. Prior research on so
On March 7th 2019, Iceland delivered a joint statement at the UN Human Rights Council on behalf of 36 states, publicly condemning Saudi Arabia's detention of ten named women human rights defenders and calling for accountability in the killing of journalist Jamal Khashoggi. The intervention is widely cited as an instance of small-state leadership, but whereas the small-state diplomacy literatur
