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A total of 15 SNPs within complement genes and present on the ImmunoChip were analyzed in The Environmental Determinants of Diabetes in the Young (TEDDY) study. A total of 5474 subjects were followed from three months of age until islet autoimmunity (IA: n = 413) and the subsequent onset of type 1 diabetes (n = 115) for a median of 73 months (IQR 54-91). Three SNPs within ITGAM were nominally asso

This research paper investigates the suitability of ceramic multi-component materials, which are found on the Martian and Lunar surfaces, for 3D printing (aka Additive Manufacturing) of solid structures. 3D printing is a promising solution as part of the cutting edge field of future in situ space manufacturing applications. 3D printing of physical assets from simulated Martian and Lunar regolith w

Powder Bed Fusion (PBF) is a range of advanced manufacturing technologies that can fabricate three-dimensional assets directly from CAD data, on a successive layer-by-layer strategy by using thermal energy, typically from a laser source, to irradiate and fuse particles within a powder bed.The aim of this paper was to investigate the application of this advanced manufacturing technique to process c

The formation of smart Lab-on-a-Chip (LOC) devices featuring integrated sensing optics is currently hindered by convoluted and expensive manufacturing procedures. In this work, a series of 3D-printed LOC devices were designed and manufactured via stereolithography (SL) in a matter of hours. The spectroscopic performance of a variety of optical fibre combinations were tested, and the optimum path l

Purpose - The purpose of this paper is to investigate the effect of the main process parameters of laser melting (LM) type additive manufacturing (AM) on multi-layered structures manufactured from JSC-1A Lunar regolith (Moondust) simulant powder. Design/methodology/approach - Laser diffraction technology was used to analyse and confirm the simulant powder material particle sizes and distribution.

The reliance on market solutions by the Swedish public sector has increased significantly in recent decades. The Swedish example is characterized by an openness to market solutions in many public-sector activities and by a mix of procurement arrangements and choice-based arrangements. The overall experience is that the consequences of the extension of market solutions have been less profound than

Ultrasonic Additive Manufacturing (UAM) enables the integration of a wide variety of components into solid metal matrices due to the process induced high degree of metal matrix plastic flow at low bulk temperatures. Exploitation of this phenomenon allows the fabrication of previously unobtainable novel engineered metal matrix components.The feasibility of directly embedding electrical materials wi

Ultrasonic Additive Manufacturing (UAM) is an advanced manufacturing technique, which enables the embedding of electronic components and interconnections within solid aluminium structures, due to the low temperature encountered during material bonding. In this study, the effects of ultrasonic excitation, caused by the UAM process, on the electrical properties and the microstructure of thermally cu

Ultrasonic consolidation (UC) has been proven to be a suitable method for fiber embedment into metal matrices. To aid successful embedment of high fiber volumes and to ensure their accurate positioning, research on producing microchannels in combination with adjacent shoulders formed by distribution of the melt onto unique UC sample surfaces with a fiber laser was carried out. This paper investiga

The formation of smart, Metal Matrix Composite (MMC) structures through the use of solid-state Ultrasonic Additive Manufacturing (UAM) is currently hindered by the fragility of uncoated optical fibers under the required processing conditions. In this work, optical fibers equipped with metallic coatings were fully integrated into solid Aluminum matrices using processing parameter levels not previou

This chapter explores the ultrasonic additive manufacturing (UAM) advanced solid-state metal additive/subtractive manufacturing process that combines ultrasonic welding and computer numerical control milling to fabricate solid metal components, layer-by-layer, from metal foils. The chapter will discuss the three key abilities of UAM: complicated geometries, dissimilar material bonding, and object

Ultrasonic Additive Manufacturing (UAM), or Ultrasonic Consolidation as it is also referred, is a hybrid form of manufacture, primarily for metal components. The unique nature of the process permits extremely novel functionality to be realised such as multi-material structures with embedded componentry. UAM has been subject to research and investigation at Loughborough University since 2001. This

Ultrasonic Consolidation (UC) is a manufacturing technique based on the ultrasonic joining of a sequence of metal foils. It has been shown to be a suitable method for fiber embedment into metal matrices. However, integration of high volume fractions of fibers requires a method for accurate positioning and secure placement to maintain fiber layouts within the matrices. This paper investigates the u

Ultrasonic Additive Manufacturing (UAM) has been subject to research and investigation at Loughborough University since 2001. In recent years, three particular areas of significant focus have been: The influence of pre-process material texture on interlaminar bonding. Secure fibre positioning through laser machined channels. Freeform electrical circuitry integration. This paper details the key fin

Ultrasonic Consolidation (UC) is an additive manufacturing technology which is based on the sequential solid-state ultrasonic welding of metal foils. UC presents a rapid and adaptive alternative process, to other metal-matrix embedding technologies, for 'smart' metal composite material production. A challenge that exists however relates to optimising, for bond density and plastic flow, the interla

Ultrasonic Consolidation (UC) is a manufacturing technique based on the ultrasonic metal welding of a sequence of metal foils which are bonded to one another in a layer by layer manner. It combines the ability of additive and subtractive manufacturing techniques to create complex three-dimensional shapes. Due to moderate applied pressures and the relatively low temperatures experienced by a sample

Future 'smart' structures have the potential to revolutionize many engineering applications. One of the possible methods for creating smart structures is through the use of shape memory alloy (SMA) fibres embedded into metal matrices. Ultrasonic consolidation (UC) allows the embedding of SMAs into metal matrices while retaining the SMA's intrinsic recoverable deformation property. In this work, Ni

Yacon (Smallanthus sonchifolius Poepp. & Endl.) roots are largely grown in Andean countries and have attracted recent interest due to their antioxidant and prebiotic effects. Yacon is typically consumed as a fruit due to its sweet taste and juiciness. The macromolecular properties of an aqueous extract of yacon are investigated using asymmetric flow field-flow fractionation (AF4) coupled to UV

Periodiska systemet växer - existensen av nya supertunga grundämnen rapporteras och verifieras fortlöpande allteftersom acceleratortekniken och analysmetoderna blir alltmer kraftfulla. Vi talar om enstaka atomer av mycket kortlivade isotoper, framställda genom kärnreaktioner. Deras kemi är av naturliga skäl outforskad.Verifiering och namngivning av dessa grundämnen är en komplicerad procedur.