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Gallstone disease is common in the Western world, and approximately 15,000 cholecystectomies and 9000 endoscopic retrograde cholangiopancreatographies (ERCPs) are performed each year in Sweden. While being safe, the high frequency of these procedures has a significant cumulative impact on health in the community, exceeding those of many complex procedures for malignant conditions. Compliance with

We present a method for reweighting flavor selection in the Lund string fragmentation model. This is the process of calculating and applying event weights enabling fast and exact variation of hadronization parameters on pre-generated event samples. The procedure is post hoc, requiring only a small amount of additional information stored per event, and allowing for efficient estimation of hadroniza

Accurate hygrothermal simulations are essential for assessing moisture safety in buildings, particularly under future climate conditions and extreme events. While the impacts of urban microclimates on energy performance, thermal comfort, and health have been extensively studied, their influence on hygrothermal simulations remains underexplored. This study addresses this gap by evaluating the impac

Intestinal immunity defends against enteric pathogens, mediates symbiotic relationships with the resident microbiota, and provides tolerance to food antigens, safeguarding critical nutrient absorption and barrier functions of this mucosal tissue. Despite the abundance of tissue resident activated T cells, their contributions to these various roles remain poorly understood. Here, we identify a domi

Background: Although it has been suggested that the hippocampus and amygdala (HA) are involved in the neurobiology of obsessive– compulsive disorder (OCD), volumetric findings have been inconsistent, and little work has been undertaken on the volumetry of the heterogeneous anatomic units of HA, with their specific functions and cytoarchitecture, in OCD. We sought to explore potential sources of he

Objectives To study the effect of a progressively enhanced rest–shade–hydration–hygiene (RSHH) intervention on kidney injury and inflammation biomarkers, and rates of clinical acute kidney injury (AKI) in Nicaraguan sugarcane workers with a very high rate of chronic kidney disease of non-traditional origin (CKDnt). Methods We analysed serum creatinine and C-reactive protein (CRP) and leukocyturia

Alveoli are sac-like structures in the distal lung specialised for gaseous exchange. Alveolar epithelium facilitates efficient respiration through a thin and robust arrangement of type-I (AT1) and type-II (AT2) pneumocytes, supported by tight junctions and surfactant-rich alveolar lining fluid. Chronic diseases like pulmonary fibrosis, asthma, and sarcoidosis compromise alveolar integrity, resulti

Bakgrund: Sepsis är en av de främsta orsakerna till död bland barn globalt och utgör därmed ett allvarligt folkhälsoproblem. Det är ett tidskritiskt tillstånd där tidig identifiering är avgörande men ofta utmanande inom akutsjukvården. Syfte: Syftet var att sammanställa vilka faktorer som påverkar tidig identifiering av sepsis hos barn. Metod: En systematisk litteraturstudie baserat på 12 studier

Bakgrund: Fluktuerande patientflöden och begränsade resurser är vanliga utmaningar på akutmottagningar världen över. I sådana situationer spelar triage en central roll för att säkerställa rättvis bedömning och prioritering av patienter. Det är därför viktigt att undersöka akutsjuksköterskors upplevelser av triage på akutmottagningen, då det kan belysa potentiella hinder och bidra till förbättringa

Beijing is particularly prone to frequent wintertime haze episodes. In this study, we introduce the FLEXPART (FLEXible PARTicle dispersion model) and SOSAA (the model to Simulate the concentration of Organic vapors, Sulfuric Acid, and Aerosols) modeling system for air quality analysis and applied the newly developed modeling system to a severe pollution episode during a case study in Beijing in No

Neurodegenerative disorders, such as Alzheimer's and Parkinson's diseases, are associated with the formation of amyloid fibrils. The DNAJB6b (JB6) chaperone greatly inhibits the disease-related self-assembly of amyloid peptides in an ATP-independent manner. The molecular basis of this process is, however, not understood. Here, we studied the low complexity linker between the N- and C-terminal doma

This paper introduces a novel approach for transitioning from high-granularity Ray-Tracing (RT) channel simulations to channel emulation, accompanied by an over-the-air test. The RT simulation is performed on a Vehicle-to-Vehicle (V2V) communication drive scenario generating basis for channel emulation in a channel emulator. The channel simulation, and the accompanying channel emulation, also enab

The present work provides a new perspective on super adiabatic combustion (SAC) of fuel/air mixtures involving methane, ethane, propane, butane, heptane, iso-octane, 1-hexene, toluene, ammonia, and hydrogen. The simulations cover the temperature range of 1200–2000 K, initial pressures of 1–50 atm, and equivalence ratios of 0.5–2.0. The detailed chemical kinetic mechanism C3MechV3.5 has been used f

Over the past decade, the far-right has become normalised globally. The tolerance and wilful welcoming of these once-shunned ideologies challenge the weakened modern liberal order and signify its limitations as modernity’s symbolic authority. This phenomenon involves an unprecedented ontology in which far-right fantasies of “stolen” ethnocultural wholeness and supremacy propagate through social me

The increasing threat of soil degradation presents significant challenges to soil health, especially within agroecosystems that are vital for food security, climate regulation, and economic stability. This growing concern arises from intricate interactions between land use practices and climatic conditions, which, if not addressed, could jeopardize sustainable development and environmental resilie

Considering the distinct etiological pathways and molecular characteristics of different lung cancer subtypes, it is crucial to develop subtype-specific prevention strategies and therapeutic targets. This study aimed to identify protein biomarkers and potential therapeutic targets for specific subtypes of lung cancer by integrating population-based observational studies and Mendelian randomisation

Background: Air pollution has been linked to breast cancer risk, but previous studies have seldom considered specific exposure windows, like pregnancy. During pregnancy the breast undergoes substantial changes and exposures may have a stronger impact than if they occurred during other time periods. This study aims to identify associations between ambient air pollution exposure during pregnancy and

Purpose of Review: Summarize recent literature on: understanding of and emotional reactions to type 1 diabetes (T1D) risk; willingness to be screened; behavioral responses to T1D-risk screening results; and provider attitudes/concerns about general population screening. Recent Findings: Difficulty understanding what it means to be at increased risk for T1D is common; anxiety about increased risk m