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Aim: Limited evidence exists on the effects of endocrine-disrupting chemical exposure on metabolic dysfunctionassociated steatotic liver disease (MASLD) in adolescents. We aimed to assess the effects of multiple chemicals on the hepatic steatosis index (HSI) and MASLD in adolescents, and to further explore the potential roles of inflammation and lifestyle factors. Methods: Associations between che

This study aims to facilitate the study of traffic dynamics in wildfire evacuation scenarios. To do so, it defines a set of traffic performance indicators to investigate traffic dynamics before and during wildfire evacuation events. These indicators include the following: system efficiency, travel time ratio, level of service, and jam time. To highlight the benefits and effectiveness of using thes

Communities living in areas of extraction often find ways to overcome or resist destructive legacies, but researchers lack a deep understanding of the mechanisms by which this is done. This article helps to address this gap by employing the theoretical framework of a sacrifice zone to a case study of Yellowknife, Canada and nearby mining projects. By analyzing a combination of interview and site v

The development of the protect-annealing method has extended the superconductivity of the electron-doped cuprate Pr1.3-xLa0.7CexCuO4 (PLCCO) into lower Ce concentrations, while the superconducting volume fraction decreases with underdoping. Employing angle-resolved photoemission spectroscopy with a microfocused beam, we investigated the electronic structure of protect-annealed PLCCO (x=0.08) with

Αποτελεί η Κίνα κομμάτι του κόσμου;Αυτή η ερώτηση, παρά τον φαινομενικά ρητορικό της χαρακτήρα, αντικατοπτρίζει μια βαθιά ριζωμένη αντί­ληψη που κυριαρχεί σε μεγάλο μέρος του πολιτικού, δημοσιο­γραφικού και δημόσιου λόγου στη Δύση: ότι η Κίνα αποτελεί το «θεμελιωδώς διαφορετικό Άλλο», αποκομμένο από τον «πραγ­ματικό» κόσμο. Παρά τη σαραντάχρονη ενσωμάτωσή της στο παγκόσμιο κοινωνικοοικονομικό σύστ

The biogeophysical forcing resulting from the change in land-surface properties (such as albedo) is of particular interest as it can increase, decrease, or offset the biogeochemical forcing resulting from the changes in atmospheric greenhouse gas concentrations due to deforestation, forest management, or reforestation/afforestation (i.e., land-use/land-cover change, LULCC). Moreover, the biogeophy

Background and objective: Although cardiovascular toxicity from modern systemic treatments in metastatic hormone-sensitive prostate cancer (mHSPC) remains a concern, real-world data are limited. We aimed to characterise patients treated for mHSPC across multiple large cohorts and estimate cardiovascular adverse event (AE) risks. Methods: Leveraging PIONEER's Big Data platform, with databases stand

The effects of atmospheric aerosols are key uncertainties in climate models. One reason is the complex aerosol composition which includes a relatively large fraction of organics. Another reason is the small size of aerosols, which makes surface effects and processes important. These two factors make surface-active organics relevant for atmospheric aerosols, as they can affect crucial processes, su

Accurate labels are critical for deriving robust machine learning models. Labels are used to train supervised learning models and to evaluate most machine learning paradigms. In this paper, we model the accuracy and cost of a common weak labeling process where annotators assign presence or absence labels to fixed-length data segments for a given event class. The annotator labels a segment as "pres

Background: Despite considerable interest in the consequences of benzodiazepine and benzodiazepine-related Z-drug (BZDR) use, little is known about whether and how initiation of BZDR treatment relates to the development of alcohol- and drug-related problems. Aims: This study aimed to examine the association of incident BZDR dispensing with subsequent alcohol- and drug-related problems. Methods: Th

Event cameras and LiDARs provide complementary yet distinct data: respectively, asynchronous detections of changes in lighting versus sparse but accurate depth information at a fixed rate. To this day, few works have explored the combination of these two modalities. In this article, we propose a novel neural-network-based method for fusing event and LiDAR data in order to estimate dense depth maps

Many animals undergo irreversible ontogenetic color changes (OCCs), yet these changes are often overlooked despite their potential ethological relevance. The problem is compounded when OCCs involve wavelengths invisible to humans. Wall lizards can perceive ultraviolet (UV) light, and their conspicuous ventral and ventrolateral coloration—including UV-reflecting patched—likely serves social communi

Asthma is a common, multifaceted respiratory disease with a major impact on quality of life. Despite increased insights into mechanisms underlying various asthma phenotypes and endotypes and the availability of targeted biologic treatment options, the disease remains uncontrolled in a substantial proportion of patients with risk of exacerbations, requiring systemic corticosteroids, and with progre

Fine-grained windblown deposits (loess) in which fossil soils (palaeosols) are preserved are excellent records of past climate. However, so far paleoclimate reconstruction studies conducted on such loess-palaeosol sequences (LPS) in SE Europe were focused on the climate changes of the last one or two glacial-interglacial cycles, while almost no attention has been directed to the climate of the cur

Normally, the measurement limit for luminescence analysis of quartz is 50-70 ka with the most widely used single aliquot regeneration (SAR) protocol, consequently, the dating of MIS 3 and MIS 4 samples or older is problematic using quartz. However, recent studies propose that the sensitivity-corrected multiple aliquot regenerative dose (SMAR) measurement technique has the potential to extend the d

BACKGROUND AND OBJECTIVE: Bacillus Calmette-Guérin (BCG) reduces disease recurrence and progression in intermediate- and high-risk non-muscle-invasive bladder cancer (NMIBC). BCG-associated adverse events during instillations are common, leading to treatment cessation. Prophylactic use of quinolones in conjunction with BCG instillations is one approach for reducing BCG-associated adverse events. O

The Danube fluvial terrace in Velika Vrbica is situated at the westernmost edge of the Wallachian basin, Serbia. The profile is positioned in a gully valley with a base consisting of point bar sands interlayered with overbank clay deposits, which are together covered by loess sediments. The investigated loess-paleosol sequence (LPS) has a height of 11.15 m and has been sampled at 5 cm intervals fo

Objective: The objective of this study was to compare health-related quality of life (HRQoL) and work productivity in axial SpA (axSpA) and non-axSpA patients with chronic back pain of <2 years. Methods: Baseline and 2-year data for patients included in the SPondyloArthritis Caught Early cohort were analysed. HRQoL was assessed by the physical (PCS) and mental component summary (MCS) scores of the