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For patients hospitalized with severe influenza A virus infection, morbidity and mortality remain high. MHAA4549A, a human monoclonal antibody targeting the influenza A virus hemagglutinin stalk, has demonstrated pharmacological activity in animal studies and in a human influenza A challenge study. We evaluated the safety and efficacy of MHAA4549A plus oseltamivir against influenza A virus infecti
We consider the problem of distributed decision making in a quadratic game between a team of players and nature. Each player has limited information that could be different from the other players in the team. We show that if there is a solution to the minimax team problem, then the linear policies are optimal, and we show how to find the linear optimal solution by solving a linear matrix inequalit
In this paper we analyze how sampling instant error affects the receiver performance in raised-cosine filtered DS-CDMA systems. An expression is presented for the Signal to Inter Chip Interference (S/ICI) ratio as a function of the sampling error characteristics and Raised-cosine roll-off factor. Finally, we use the analysis in the paper to derive sufficient sampling resolution for the high perfor
An H∞ control system is considered with the constraint that process disturbances and measurement noise cannot both be large. It is unnatural to couple process disturbance and measurement noise in this way. It is better to assume that some signals are stochastic. Explicit formulas for the value of the game are determined.
A simple second order feed-forward disturbance attenuation problem is analyzed. The problem has one free parameter, the control weight ρ in the loss function. It is found that controller structure and uniqueness for H∞ - control, in the optimal case, changes when ρ is varied. Sensitivity to initial conditions is also drastically changed. The example is simple enough to allow a solution by formula
This study deals with the Swedish cultural heritage in the United States and aims to examine how and why individuals living in the U.S. select and affirm certain concepts and phenomena as particularly Swedish. The focus is on Lindsborg, Kansas, a town of some 3,000 inhabitants who identify themselvesas Swedish Americans, Swedes, and non-Swedes, and on how they organize, prepare and enact parades i
BACKGROUND: Technical applications can promote home-based exercise and physical activity of community-dwelling stroke survivors. Caregivers are often able and willing to assist with home-based exercise and physical activity but lack the knowledge and resources to do so. ActivABLES was established to promote home-based exercise and physical activity among community-dwelling stroke survivors, with s
The Derjaguin approximation (DA) relates the force between curved surfaces to the interaction free energy between parallel planes. It is typically derived by considering the direct interaction between the bodies involved, thus treating the effect of an intervening solvent implicitly by a rescaling of the corresponding Hamaker constant. Here, we provide a generalization of DA to the case of a molec
Relaxor ferroelectrics are technologically important materials for applications in, for example, high-temperature capacitors, transducers and nano-positioning systems. These materials have often been reported to exhibit surface or skin layers with distinct physical properties to the bulk. The control of formation and functionality of these skin layers has remained elusive and is becoming increasin
INTRODUCTION: Chronic subdural haematomas (CSDHs) are one of the most common neurosurgical conditions. The goal of surgery is to alleviate symptoms and minimise the risk of symptomatic recurrences. In the past, reoperation rates as high as 20%-30% were described for CSDH recurrences. However, following the introduction of subdural drainage, reoperation rates dropped to approximately 10%. The stand
Background: Obesity induces molecular changes that may favor tumor progression and metastatic spread, leading to impaired survival outcomes in breast cancer. Adenylate cyclase-associated protein 1 (CAP1), an actin regulatory protein and functional receptor for the obesity-associated adipokine resistin, has been implicated with inferior cancer prognosis. Here, the objective was to investigate the i
Monarch butterflies (Danaus plexippus) are prominent for their annual long-distance migration from North America to their overwintering area in Central Mexico. To find their way on this long journey, they use a sun compass as their main orientation reference but will also adjust their migratory direction with respect to mountain ranges. This indicates that the migratory butterflies also attend to
Outcome prognostication after cardiac arrest (CA) is challenging. Current multimodal prediction approaches would benefit from new biomarkers. MicroRNAs constitute a novel class of disease markers and circulating levels of brain-enriched ones have been associated with outcome after CA. To determine whether these levels reflect the extent of brain damage in CA patients, we assessed their correlation
Den klädda kroppens identiteter och förvandlingar lockar i modets metamorfoser en read nordiska akademiska skribenter att skriva om kläder, mode, kropp; om kläder mode och plats liksom om mode och makt. Tanken med boken är att överbrygga den polarisering som ibland görs mellan kläder och mode, men också studera kulturella processer om hur identitet kan baseras på något materiellt som just plagg.
Background: Women with idiopathic pulmonary arterial hypertension (IPAH) have been found to have a worse haemodynamic status at diagnosis, but better survival than men. Over the past decade, demographics have changed and new treatments have become available. The objective of this study was to investigate sex differences in an incident IPAH population diagnosed between 2008 and 2016.Methods: Differ
Outpatient pulmonary hypertension (PH) specialist centers have an important role in the optimal management of pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). The aim of the present study was to gain an understanding of the work facing nurses at the outpatient PH specialist centers in Sweden. All nurses (n = 14) working at the outpatient PH specialis
