Background: The participation of patients in clinical trials is crucial for the development of healthcare. There are several challenges in the recruitment of trial participants with acute medical conditions. The registry-based randomized DAPA-MI clinical trial recruited patients during hospitalization for myocardial infarction and provided study drugs in bottles with smart caps that used wireless

Background: There is good evidence that elevated amyloid-β (Aβ) positron emission tomography (PET) signal is associated with cognitive decline in clinically normal (CN) individuals. However, it is less well established whether there is an association between the Aβ burden and decline in daily living activities in this population. Moreover, Aβ-PET Centiloids (CL) thresholds that can optimally predi

Emulsification devices break drops by rapidly pushing them through a region of intense turbulence–a ‘turbulent pulse’. These devices are widely used in chemical engineering. However, the thermodynamic efficiency is low, and design modifications allowing more breakup at lower energy input is much in need. This study uses a combination of statistical models and direct numerical simulation coupled to

People who inject drugs are frequently colonized with Staphylococcus aureus and have an increased risk for skin and soft tissue infections. This longitudinal study aims to describe S. aureus carriage in this group and the risk for infections during a 1-year follow-up. We included 61 participants from the Malmö Needle Exchange Program. Mapping of S. aureus carriage was conducted by screening cultur

Background and purpose: Recommendations for regional radiotherapy (RT) of sentinel lymph node (SLN)-positive breast cancer are debated. We here report a RT quality assessment of the SENOMAC trial. Materials and Methods: The SENOMAC trial randomized clinically node-negative breast cancer patients with 1–2 SLN macrometastases to completion axillary lymph node dissection (cALND) or SLN biopsy only be

We present a general Fourier analytic technique for constructing orthonormal basis expansions of translation-invariant kernels from orthonormal bases of ℒ2(R). This allows us to derive explicit expansions on the real line for (i) Matérn kernels of all half-integer orders in terms of associated Laguerre functions, (ii) the Cauchy kernel in terms of rational functions, and (iii) the Gaussian kernel

Flooding is one of the main social impacts in urban areas, especially in larger, densely impermeable cities. Therefore, developing studies capable of identifying areas that are vulnerable to this type of event is crucial to provide early warning and a quick and effective response to reduce damages. Thus, this study sought to identify areas vulnerable to flood in the Igapó Lake Basin, a densely urb

The building sector is the single largest consumer of natural resources, accounting for a staggering half of global material use and over a third of energy use and carbon emissions. As a response, the circular transition in the building sector has been focused on strategies such as extracting material from demolished buildings, and design-for-disassembly in new construction projects. Sadly, signif

Background: Risky sexual behavior (RSB) is one of the major youth sexual and reproductive health problems globally, including in Ethiopia. RSB among youth increases the risk of HIV infection, other sexually transmitted infections (STIs), unintended pregnancy, and unsafe abortion. Therefore, the aim of this study was to examine RSB and its associated factors among university students in Ethiopia. M

Background: Stingless bees are vital pollinators and honey producers in the tropics. Research on stingless bees is generally underrepresented compared to the western honeybees, and while stingless bee studies from some regions are reported, there is a particular lack of reports on the species endemic to Sub-Saharan Africa. Since conventional entomological methods such as mark-recapture and radar h

FeCo nanoparticles exsolved from Co-doped Sm0.9FeO3 nanofibers with abundant oxygen vacancies (Vos) are proposed as an efficient electrocatalyst to promote nitrate reduction reaction (NITRR). Such catalyst achieves a maximum Faradaic efficiency (FE) of 90.3 % and a large NH3 yield of 17.2 mg h−1 mg−1cat. at a negatively shifted potential of −0.9 V in 0.1 M PBS with 0.1 M NaNO3, and the alloy nanop

Efficiency of protein synthesis on the ribosome is strongly affected by the amino acid composition of the assembled amino acid chain. Challenging sequences include proline-rich motifs as well as highly positively and negatively charged amino acid stretches. Members of the F subfamily of ABC ATPases (ABCFs) have been long hypothesised to promote translation of such problematic motifs. In this study

Ptychography has evolved as an important method for nanoscale X-ray imaging with synchrotron radiation. Recently, it has been proposed to work with multiple beams in parallel. The main advantage of so-called multi-beam ptychography is that larger areas can be imaged much faster than with a conventional single beam scan. We introduce adaptive multi-beam ptychography performed with two Fresnel zone

Hard X-rays are needed for non-destructive nano-imaging of solid matter. Synchrotron radiation facilities (SRF) provide the highest-quality images with single-digit nm resolution using advanced techniques such as X-ray ptychography. However, the resolution or field of view is ultimately constrained by the available coherent flux. To address this, the beam's incoherent fraction can be exploited usi

There is little published research on dissociative experiences among transgender people, and none from an in-depth qualitative perspective. In-depth, open-ended interviews (N = 7, 6 trans women, 1 trans man) were conducted to explore how dissociation is experienced (particularly among trans women)and its possible relation to negative emotions. There were several similarities across the dissociativ

BACKGROUND: Neck pain remains a persistent challenge in modern society and is frequently encountered across a wide range of occupations, particularly those involving repetitive and monotonous tasks. It might be expected that patterns of trapezius muscle activity at work, characterized by few breaks and prolonged periods of sustained muscle activity, are linked to neck pain. However, previous cross

The Athenian graffiti functions as a testament of creativity and artistry occurring during the hard times of socioeconomic and political crisis in Greece the last seven years. The impact of Greece's crisis is unavoidably presented through urban art in downtown Athens. This extensive street art practice on Athenian walls as a linguistic and imagery line is approached in this work via the semiotic a

In this paper we consider calibration of hydraulic models for district heating networks based on operational data. We extend previous theoretical work on the topic to handle real-world complications, namely unknown valve characteristics and hysteresis. We generate two datasets in the Smart Water Infrastructure Laboratory in Aalborg, Denmark, on which we evaluate the proposed procedure. In the firs