Filtyp
Antibodies targeting Ab42 are under intense scrutiny because of their therapeutic potential for Alzheimer’s disease. To enable systematic searches, we present an “antibody scanning” strategy for the generation of a panel of antibodies against Ab42. Each antibody in the panel is rationally designed to target a specific linear epitope, with the selected epitopes scanning the Ab42 sequence. By screen
Parkinson's disease (PD) is characterized by proteinaceous aggregates named Lewy Bodies and Lewy Neurites containing α-synuclein fibrils. The underlying aggregation mechanism of this protein is dominated by a secondary process at mildly acidic pH, as in endosomes and other organelles. This effect manifests as a strong acceleration of the aggregation in the presence of seeds and a weak dependence o
S-rapporten, ”en ny social bostadspolitik” levererar en bra problemanalys och flera goda målbeskrivningar men deras förslag orkar inte helt i mål, menar Ingemar Bengtsson, Universitetslektor vid Avdelningen för Fastighetsvetenskap, Lunds Universitet. Ingemar Bengtsson ifrågasätter gruppens allmänna strävan att samhället ska öka den samlade bostadskonsumtionen och efterlyser i följande kommentar me
The elegant cyclist: Cycling, fashion and femininity in Swedish and Danish women’s magazines at the turn of the 20th century.At the turn of the 20th century the new sport of cycling was endowed with femininity in Scandinavian ladies’ magazines. An analysis of the magazines Idun, Svensk Damtidning, Damernes Blad and Hjemmet between 1890 and the 1910s show that both Swedish and Danish magazines appe
This paper focuses on the question if, and if so how, the Theodosian Code, the first legal codification of the Roman Empire and its devoted to religion Book XVI, facilitated the formation and enforcement of the concept of orthodoxy and its boundaries. It uses the propositions of the Cognitive Science of Religion to advance a new understanding of the shift towards orthodoxy, as the process in which
Inflammation is implicated in the etiology of sporadic colon cancer (CC), which is one of the leading causes of cancer-related deaths worldwide. Here, we report that inhibition of the inflammatory receptor CysLT1 through its antagonist, montelukast, is beneficial in minimizing stemness in CC and thereby minimizing tumor growth in a mouse xenograft model of human colon cancer. Upon treatment with m
Fuel injection is one of the most important processes in compression-ignition internal combustion engines owing to its significant impact on the exhaust emissions and thermal efficiency. In this study, experiments were carried out to investigate the influence of injection pressure and injection timing on the temporal evolution of the injection rate and injection duration in a specially designed ex
Sequencing of immunoglobulin germline gene loci is a challenging process, e.g. due to their repetitiveness and complexity, hence limiting the insight in the germline gene repertoire of humans and other species. Through next generation sequencing technology, it is possible to generate immunoglobulin transcript data sets large enough to computationally infer the germline genes from which the transcr
Background: Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) carries risk of sudden death. We hypothesize that the S-wave angle differentiates ARVD/C with otherwise normal electrocardiograms from controls. Materials and methods: All patients met Task Force 2010 definite ARVD/C criteria. ARVD/C patients without Task Force depolarization/repolarization criteria (−ECG) were compared
Fundamental to regulatory guidelines is to identify chemicals that are implicated with adverse human health effects and inform public health risk assessors about “acceptable ranges” of such environmental exposures (e.g., from consumer products and pesticides). The process is made more difficult when accounting for complex human exposures to multiple environmental chemicals. Herein we propose a new
