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Background: Testicular germ cell cancer (TGCC) originates during fetal life. Fetal exposure to environmental chemicals may contribute to its development, but epidemiological data are lacking. We investigated per- and polyfluoroalkyl substances (PFAS), which can act as endocrine disruptors during fetal development, and TGCC risk in adulthood. Methods: We conducted a nested case-control study of 549
This paper presents the exploration of GPU-accelerated block-wise decompositions for zero-forcing (ZF) based QR and Cholesky methods applied to massive multiple-input multiple-output (MIMO) uplink detection algorithms. Three algorithms are evaluated: ZF with block Cholesky decomposition, ZF with block QR decomposition (QRD), and minimum mean square error (MMSE) with block Cholesky decomposition. T
The lifelong risk of stroke following adverse pregnancy outcomes, and potential causality, are unknown. This study examined five major adverse pregnancy outcomes and long-term risk of stroke in a large population-based cohort. Methods A national cohort study was conducted of all 2 201 393 women with a singleton delivery in Sweden during 1973–2015, followed up for stroke through 2018. Cox regressio
Effective governance and management of ecosystem functions to promote human well-being and social equity require a clear understanding of supply and demand dynamics. While this is widely acknowledged in assessments of ecosystem services, it remains largely neglected for ecosystem disservices, despite many ecosystem functions generating both services (benefits) and disservices (costs) depending on
Generalist parasites must adapt to diverse host environments to ensure their survival and transmission. These adaptations can involve fixed genetic responses, transcriptional plasticity, or epigenetic mechanisms. The avian malaria parasite Plasmodium homocircumflexum offers an ideal model for studying transcriptional variation across hosts. We experimentally inoculated P. homocircumflexum into dif
Policing roles require specific work-related characteristics (WRCs) critical for effective performance. This study identifies key WRCs for various roles within the Swedish Police—patrol officers, criminal investigators, Special Weapons and Tactics (SWAT) Teams, police chiefs, and negotiators—by analyzing data from 425 active-duty officers (30% response rate). We use the Occupational Information Ne
Radiation dosimetry and cancer risk estimations are central to virtually all radiation safety applications, optimization, and research. These estimates relate to various exposure situations including planned, existing, and emergency situations. The International Commission on Radiological Protection (ICRP) has developed a new methodology to handle the dosimetry of an acute/single intake of radionu
A mobile gamma spectrometer's series of pulse height distributions (gamma spectra) acquired when passing a point source contains enough information to derive the distance to the source, its shielding and activity. Two Excel routines, SODAC and SSC, have been developed to determine these source parameters. SODAC determines the source-road distance by finding the best fit of the measured series of t
High energy prices recently have moved nuclear power back into the limelight. The biggest risk of nuclear industry has been large-scale accidents that give rise to ground deposition of long-lived fission products such as 137Cs, notably Chernobyl in 1986 (Ukraine) and Fukushima in 2011 (Japan). In Japan, extensive land remediation of residential areas was carried out at an estimated direct cost bet
Thyroid dose estimations after nuclear power plant (NPP) accidents are traditionally based on internal uptake of radioiodine, mainly 131I, either by instrumental measurements of thyroid uptake or by ecological estimations based on geographical dispersion of the radioiodine cloud, demographics, and food habits. However, it has been shown that 134Cs and 137Cs in some cases can be the dominant contri
This paper presents the observation of four-top-quark (tt¯ tt¯) production in proton-proton collisions at the LHC. The analysis is performed using an integrated luminosity of 140 fb - 1 at a centre-of-mass energy of 13 TeV collected using the ATLAS detector. Events containing two leptons with the same electric charge or at least three leptons (electrons or muons) are selected. Event kinematics are
Executive functions are a set of cognitive skills enabling goal‑directed behaviours. Both mammals and birds have highly proficient executive functions, despite diverging from each other around 360 million years ago. This cognitive convergence is due to both taxa being tachymetabolic endotherms. They can maintain a stable and elevated body temperature with a high metabolism. However, in order to su
Late radiation-induced kidney toxicity limits molecular radionuclide therapy using radiopharmaceuticals such as 177Lu-octreotate and 177Lu-octreotide. Better kidney protection would allow higher amounts of radiopharmaceutical to be administered. Coadministration of recombinant human alpha-1-microglobulin (rA1M) has been suggested to protect kidneys from exposure from 177Lu-octreotate. Furthermore,
A field survey was conducted in Sweden with the purpose to revisit the ground deposition of Chornobyl 137Cs and the associated ambient dose equivalent rate, H∗ (10), at various measuring locations in the Gävle and Älvkarleby municipalities. The specific purpose was to compare the 137Cs deposition values as measured in situ using a field portable gamma spectrometer [3″(Ø) × 3″ NaI(Tl)-crystal] with
Introduction: Human papillomavirus (HPV) infection is associated with tonsillar and base-of-tongue squamous cell carcinomas (TSCC/BOTSCC). We evaluated the relative risk (RR) of TSCC/BOTSCC in the husbands of women with anogenital cancer using the Swedish family database. Methods: The Swedish family database includes 3.5 million families and 16 million individuals identified since 1932 and linked
In vivo preclinical X-ray micro-computed tomography (μCT) imaging is widely used to obtain three-dimensional anatomical information of small animals. However, the potential for radiation exposure to influence experimental outcomes necessitates accurate dose estimation. The aim of this study was to develop a robust and reproducible method for estimating and evaluating absorbed doses in small animal
The transverse momentum (pT) and centrality dependence of the nuclear modification factor RAA of prompt and non-prompt J/ψ, the latter originating from the weak decays of beauty hadrons, have been measured by the ALICE collaboration in Pb–Pb collisions at sNN = 5.02 TeV. The measurements are carried out through the e+e− decay channel at midrapidity (|y| < 0.9) in the transverse momentum region 1.5
INTRODUCTION: Plasma biomarkers’ utility for predicting incident mild cognitive impairment (MCI) remains unclear. We evaluated associations of plasma Alzheimer's disease (AD) biomarkers and amyloid positron emission tomography (PET) with transitions from cognitively unimpaired (CU) to MCI in the Mayo Clinic Study of Aging (MCSA) and BioFINDER-2 studies. METHODS: Associations of continuous baseline
Background and Aims: In primary sclerosing cholangitis (PSC), the risk for gallbladder malignancy is increased. Surveillance imaging is used for early diagnosis. The study aims to assess the reliability of ultrasound and magnetic resonance imaging (MRI) for the detection of gallbladder polyps in people with PSC and to define a polyp size as a cut-off at which cholecystectomy is indicated due to th
Newts have large genomes harbouring many repeat elements. How these elements shape the genome and relate to newts’ unique regeneration ability remains unknown. We present here the chromosome-scale assembly of the 20.3Gb genome of the Iberian ribbed newt, Pleurodeles waltl, with a hitherto unprecedented contiguity and completeness among giant genomes. We provide evidence that intronic repeat elemen
