Acute leukemia affects individuals of all ages and encompasses a heterogeneous group of malignancies driven by genetic alterations that give rise to leukemia stem cells (LSCs), which sustain self-renewal and drive the expansion of abnormal cells. Based on how these alterations affect maturation, acute leukemia is classified into acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). Acute leukemia affects individuals of all ages and encompasses a heterogeneous group of malignancies driven by genetic alterations that give rise to leukemia stem cells (LSCs), which sustain self-renewal and drive the expansion of abnormal cells. Based on how these alterations affect maturation, acute leukemia is classified into acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).

Acute coronary syndrome (ACS), including acute myocardial infarction (AMI), are a leading cause ofmorbidity and mortality worldwide. Accurate risk evaluation in patients presenting with chest pain isessential for optimizing emergency department (ED) resource allocation and patient outcomes. Currentclinical decision support tools rely on structured risk scores and biomarker measurements, such as hi

Background: Metastasis to lymph nodes is strongly associated with reduced survival in breast cancer patients. To increase the understanding on how lymph node metastasis impairs the local immune response in affected lymphnodes, we here studied spatial proteomic changes of critical lymph node immune populations in uninvolved lymph nodes (UnLN) and paired lymph nodes with metastases (LNM) from five b

Slow- and non-growing bacterial populations, along with intracellular pathogens, often evade standard antibacterial treatments and are linked to persistent and recurrent infections. This necessitates the development of therapies specifically targeting nonproliferating bacteria. To identify compounds active against non-growing uropathogenic Escherichia coli (UPEC) we performed a drug-repurposing sc

Deaths of despair (DoD), encompassing suicide, drug overdose, and alcohol-related mortality, are often linked to social and psychological distress. This study examined the long-term risk of DoD among individuals previously hospitalized for suicide attempts, with a focus on substance use problems and psychiatric disorders as potential risk factors. A prospective cohort of 1044 individuals admitted

Introduction: Genome-wide association studies (GWAS) identified a locus on chromosome 4q21.1, spanning the Family With Sequence Similarity 47 Member E (FAM47E), Starch Binding Domain 1 (STBD1), Coiled-Coil Domain Containing 158 (CCDC158), and Shroom Family Member 3 (SHROOM3) genes, to be associated with kidney function markers. Functional studies implicated SHROOM3 as the effector gene, demonstrat

BACKGROUND AND PURPOSE: Perfusion and perfusion-related parameter maps obtained using dynamic susceptibility contrast (DSC) MRI and dynamic contrast enhanced (DCE) MRI are both useful for clinical diagnosis and research. However, using both DSC and DCE MRI in the same scan session requires two doses of gadolinium contrast agent. The objective was to develop deep-learning based methods to synthesiz

BACKGROUND: The Human Protein Atlas, with more than 10 million immunohistochemical images showing tissue- and cell-specific protein expression levels and subcellular localization information, is widely used in kidney research. The Human Protein Atlas contains comprehensive data on multi-tissue transcript and protein abundance, allowing for comparisons across tissues. However, while visual and intu

Background: Differentiated thyroid carcinoma (DTC) is occurring three times more frequently in females than in males. However, the underlying biological mechanisms driving this discrepancy remain poorly understood. To investigate the causal role of sex hormones and reproductive factors in the risk of DTC, we implemented a two-sample Mendelian randomization (MR) analysis. Methods: We utilized genom

Being deeply embedded in the mythological framework of old-school Christian angelology, the theodicy presented in this article outlines a thoroughgoing and unexpectedly simple solution to the problem of evil. Unlike other Satan-oriented theodicies, whose central idea is that natural evil is reducible to moral evil by taking the malevolent actions of demons into consideration, it accounts for both Being deeply embedded in the mythological framework of old-school Christian angelology, the theodicy presented in this article outlines a thoroughgoing and unexpectedly simple solution to the problem of evil. Unlike other Satan-oriented theodicies, whose central idea is that natural evil is reducible to moral evil by taking the malevolent actions of demons into consideration, it accounts for both

Capturing ultrafast phenomena requires imaging techniques capable of resolving events occurring on femtosecond time scales. Traditional high-speed cameras are limited by electronic readout speeds and cannot reach the terahertz (THz) frame rates necessary to observe processes such as laser filamentation, plasma formation, or light-matter interactions in general. To overcome these limitations, this

Purpose: Mental illness due to longstanding stress is increasing. It has been shown that service users with mental illness may benefit from nature-based interventions (NBI), including equine-assisted therapy, to support their health, recovery, and activity level of daily life. However, the evidence base to support this is still weak. The aim was thus to evaluate and provide knowledge of the possib