Neutron macromolecular crystallography (NMX) has the potential to provide the experimental input to address unresolved aspects of transport mechanisms and protonation in membrane proteins. However, despite this clear scientific motivation, the practical challenges of obtaining crystals that are large enough to make NMX feasible have so far been prohibitive. Here, the potential impact on feasibilit

The purpose of this study was to investigate breathing-motion induced interplay effects for stereotactic body radiotherapy (SBRT) of liver tumours treated with flattening-filter free (FFF) volumetric modulated arc therapy (VMAT). Ten patients previously treated with liver SBRT were included in this study. All patients had four-dimensional computed tomography (4DCT) scans acquired prior to treatmen

In this article national statistics from Swedish sickness funds are analysed from 1892 to 1954. The study is intended to provide better knowledge of changes in sickness claims, and to contribute to the discussion of morbidity trends. National statistics on sickness benefits are available from 1892, and are studied until the introduction of mandatory health insurance in 1955. Membership of Swedish

Dysentery, or rödsot, as the disease was previously known in Sweden, continues to be a major scourge in developing countries. However, the disease has almost disappeared in the West. Very different circumstances prevailed before infectious diseases declined as some of the major causes of death during the 19th century. In that era, 10,000 people could die of dysentery in a single year in Sweden. Th

A positive correlation between virus evolutionary rate and disease progression has been shown for human immunodeficiency virus type 1 (HIV-1) infection. Much less is known about HIV-2, the second causative agent of AIDS. We analyzed 528 HIV-2 env V1-C3 sequences generated from longitudinal plasma samples that were collected from 16 study participants during a median observation time of 7.9 years (

Realization of robust coherent quantum phase slips represents a significant experimental challenge. Here we propose a design consisting of multiple nanowire junctions to realize a phase-slip flux qubit. It admits good tunability provided by gate voltages applied on superconducting islands separating nanowire junctions. In addition, the gates and junctions can be identical to or distinct from each

Although endometriosis is considered an inflammatory disease, no reliable diagnostic biomarkers exist for use in clinical practice. The aim was to investigate the inflammatory profile in endometriosis using an exploratory approach of inflammation-related proteins. Patients with laparoscopy-verified endometriosis (N = 172), women with microscopic colitis (N = 50), healthy controls (N = 31), and age

The notion of quiet areas has received increasing attention within the EU in recent years. The EU Environmental Noise Directive (END) of 2002 stipulates that member states should map existing quiet areas and formulate strategies to keep these quiet. Quiet areas could play an important role in balancing densified urban development by ensuring access to relative quietness and associated health benef

Smoking is a major heritable and modifiable risk factor for many diseases, including cancer, common respiratory disorders and cardiovascular diseases. Fourteen genetic loci have previously been associated with smoking behaviour-related traits. We tested up to 235,116 single nucleotide variants (SNVs) on the exome-array for association with smoking initiation, cigarettes per day, pack-years, and sm

This article is the author's trial lecture for appointment as Reader in practical theology, held on 3 November 2016. The article is based on the author's own research and practical work with funerals for more than thirty years, but also on secondary research. The article shows the interplay between micro rituals, interpretations of faith, and interpretations of life. The article briefly discusses

Although Scandinavia is arguably peripheral in the global literary system, it nevertheless holds a surprisingly prominent position in the field of translation, Swedish and Danish being among the ten most translated languages in the world (Lindqvist, 2015). What literature is selected for translation and introduction into new linguistic contexts is not a coincidence, but has to do with economic fac

The past year saw progress in acute treatment of ischaemic stroke, but large inequalities in stroke services were revealed, warranting strategical initiatives to improve treatment access. Reclassification of stroke as a disease of the nervous system in the WHO International Classification of Diseases 11th revision is likely to help such initiatives.

How does dull turn into cool? Every now and then new markets emerge and consumption that used to be mundane and insignificant transforms into something socially significant. Using the theoretical lens of cultural system transformation, this research set out to analyze how consumers, through their identity work, unintentionally transform a market by negotiating its symbolic boundaries and expanding

Currently, consumer decision-making is influenced by the spread of technology that has made multi-channel retailing possible. Multi-channel retailing can be defined as a retailer using a combination of separate and independent channels without any overlap for promoting and selling products and services. This study contributes to three research streams: consumer decision-making, multi-channel retai

The identification of novel antimetastatic therapeutic targets is necessary for improved treatment of patients with acquired BRAF inhibitor-resistant (BRAFi-R) melanoma, in whom metastasis is a major concern. Our present study focused on the identification of such targets to explore novel antimetastatic therapeutic options for BRAFi-R melanoma patients. We confirmed the development of BRAFi resist

The carbon cycle of the terrestrial biosphere plays a vital role in controlling the global carbon balance and, consequently, climate change. Reliably modeled CO2 fluxes between the terrestrial biosphere and the atmosphere are necessary in projections of policy strategies aiming at constraining carbon emissions and of future climate change. In this study, SMOS (Soil Moisture and Ocean Salinity) L3