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Astrocytes are essential for maintaining neuronal health and regulating the brain's inflammatory environment. In this study, we developed an adeno-associated viral vector (AAV9) designed to selectively overexpress glial cell line-derived neurotrophic factor (GDNF) in astrocytes, using the astrocyte-specific GFAP promoter and TdTomato for transduction tracking. This approach yielded targeted GDNF e
Bakgrund: Det är ett välkänt faktum att den demografiska utvecklingen kommer att kräva nya arbetssätt för att äldre ska kunna få vård i liknande omfattning som tidigare. Förhoppningen har ställts till införandet av välfärdsteknik som en viktig del av kompetensförsörjningen, inte bara för att den kan bidra till att upprätthålla välfärden trots fler äldre, utan också genom att göra äldreomsorgsarbet
Tackling biodiversity loss requires not only scaling up financial resources but also improving the governance of how such resources are mobilized, allocated, and accounted for. This paper reviews recent peer-reviewed literature (2019–2023) on biodiversity finance governance, focusing on three interrelated themes: financial instruments and mechanisms, governance structures, and critical and normati
Natural gas/diesel dual-fuel combustion is a novel technique that offers high thermal efficiency and reduced emissions without requiring extensive hardware changes or complex aftertreatment systems. Previous study conducted on the same setup has shown that increasing the diesel mass split ratio (SR) between two injections and advancing the start of first injection (SOI1) improved NOx, HC emissions
It has been shown by Fano [1] that photoionization of a cesium atom by a laser pulse tuned to the vicinity of a Cooper minimum generates spin-polarized electrons. Here we show that while photoionization of rare gases does not provide large spin polarization in the vicinity of the Cooper minimum, the Fano resonances yield much higher overall spin polarization (≥40%). The spin polarization increases
With calls for increased greenery in cities to safeguard biodiversity and its associated benefits to humans, urban vegetation must be managed carefully and efficiently. It is time to change paths from current spurious attempts to manufacture resilience and instead usher in evidence-based urban greening to secure ecosystems for the future.
Anthropogenic land-use change (LUC) substantially impacts climate dynamics, primarily through modifications in the surface biogeophysical (BGP) and biogeochemical (BGC) fluxes, which alter the exchange of energy, water, and carbon with the atmosphere. Despite the established significance of both the BGP and BGC effects, their relative contribution to climate change remains poorly quantified. In th
This paper investigates the relationship between debt, time and power by studying over-indebted young adults’ lived experiences of temporality. Empirically, the paper is based on recurrent interviews with 18 over-indebted young adults (aged 18–25) in Sweden and is analytically centred on three phases of indebtedness: entering the credit market, becoming over-indebted, and being over-indebted. The
The transition to the Nordic Bronze Age included new technological innovations, social institutions and sociopolitical structures pushed by extensive long-distance exchange of metals and other exotica. However, traditional views often oversimplify this as a simple two-way trade system, failing to adequately explain the complex interactions in and between the regions like Scandinavia in which the s
Main conclusion: Chloroplast protein transport depends on the SEC1 translocase. Barley xan-m mutants, deficient in SECA1, lack chlorophyll and die as seedlings. Their yellow phenotype indicates that carotenoid chemistry is less SEC1-dependent. Chloroplast proteins encoded by genes located in the cell nucleus need to be transported across up to three chloroplast membranes to find its correct locati
This article explores civil society actors’ framing of hate speech, threats, and harassment in relation to the type of harasser or perpetrator. The article draws on a qualitative study with elected representatives, paid employees, and volunteers in different Swedish Civil Society Organisations and social movements. The phenomena are analysed from a relational perspective and theories of civil sociThis article explores civil society actors’ experiences of hate speech, threats, and harassment; specifically those of the harassers or perpetrators. The article draws on a qualitative study with elected representatives, paid employees, and volunteers in different Swedish Civil Society Organisations and social movements. The phenomena are analysed from a relational perspective and theories that fr
Background Stressful life events (SLEs) increase the risk for subsequent major depression (MD) episodes. Most prior studies of SLEs utilized questionnaires or interview-based assessments. We sought to develop and evaluate an environmental risk score (ERS) for MD from multiple classes of SLEs obtained from national Swedish registries. Methods We assessed, in the entire adult population of Sweden (n
BACKGROUND: Treatment decisions in metachromatic leukodystrophy (MLD), a rare life-threatening neurological disease, are challenging. Hematopoietic stem cell transplantation or autologous stem-cell-based gene therapy can be life-changing but come with uncertainties, risks, and high costs. To address this, the international MLD treatment eligibility panel was established in collaboration with the E
