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Biomarkers of exposure in environment-wide association studies – Opportunities to decode the exposome using human biomonitoring data

Background: The European Union's 7th Framework Programme (EU's FP7) project HEALS – Health and Environment-wide Associations based on Large Population Surveys – aims a refinement of the methodology to elucidate the human exposome. Human biomonitoring (HBM) provides a valuable tool for understanding the magnitude of human exposure from all pathways and sources. However, availability of specific bio

Trace elements and ALAD gene polymorphisms in general population from three uranium legacy sites – A case study in Kyrgyzstan

At three uranium (U) legacy sites in Kyrgyzstan, namely, Kadji Sai, Mailuu-Suu and Sumsar, an initial human bio-monitoring programme was introduced as a complementary activity to environmental impact studies in these areas. The aim was to assess trace element (TE) contents in blood and genetic susceptibility for Pb as one of the contaminants. The programme included the determination of 9 TE in blo

Glyphosate and AMPA in Human Urine of HBM4EU Aligned Studies : Part A Children

Few data are available on the exposure of children to glyphosate (Gly) in Europe. Within HBM4EU, new HBM exposure data were collected from aligned studies at five sampling sites distributed over Europe (studies: SLO CRP (SI); ORGANIKO (CY); GerES V-sub (DE); 3XG (BE); ESTEBAN (FR)). Median Gly concentrations in urine were below or around the detection limit (0.1 µg/L). The 95th percentiles ranged

Seasonal glyphosate and AMPA levels in urine of children and adolescents living in rural regions of Northeastern Slovenia

There are extensive data on the toxicity of glyphosate (GLY) based herbicides (GBH), however the interpretation of some data (e.g. carcinogenic effect) are subject to controversy. For the appropriate health risk assessment more data on exposure levels in the general population, especially in susceptible groups such as pregnant women, the elderly and children are needed. The aims of the present stu

Bioaccumulation of arsenic species in rays from the northern Adriatic Sea

The difference in arsenic concentration and speciation between benthic (Pteromylaeus bovinus, Myliobatis aquila) and pelagic rays (Pteroplatytrygon violacea) from the northern Adriatic Sea (Gulf of Trieste) in relation to their size (age) was investigated. High arsenic concentrations were found in both groups with tendency of more efficient arsenic accumulation in benthic species, particularly in

Urinary concentrations of phthalate/DINCH metabolites and body mass index among European children and adolescents in the HBM4EU Aligned Studies : A cross-sectional multi-country study

Background: Phthalates are ubiquitous in the environment. Despite short half-lives, chronic exposure can lead to endocrine disruption. The safety of phthalate substitute DINCH is unclear. Objective: To evaluate associations between urinary concentrations of phthalate/DINCH metabolites and body mass index (BMI) z-score among children and adolescents. Method: We used Human Biomonitoring for Europe A

Associations between APOE genotypes, urine 8-isoprostane and blood trace elements in middle-aged mothers (CROME study)

Background: There is almost no data on the combined associations between apolipoprotein E gene (APOE) genotypes, trace elements (TEs), and lipid peroxidation in vivo. The aim of our study was to evaluate the association between APOE genotypes and TE levels in blood (B-TEs) and erythrocytes (E-TEs), and 8-isoprostane in urine (U-8-isoprostane) in women with low exposure to potentially toxic TEs and

Bronzization and the people : Bioarchaeological perspectives on Bronze Age individuals and populations in Southern Sweden

Globalisation is characterised not only by long-distance exchange by commodities and people, but also by a microbial unification of the world (une unification microbienne du monde), as was described by Emmanuel Le Roy Ladurie in the 1970s. Proof of microbial unification can be seen through the dramatic consequences of the Black Death in the 14th century CE as well as the Covid-19 pandemic, which i

How social desirability influences the relationship between measures of personality and key constructs in positive psychology

Does socially desirable responding produce exaggerated correlations between self-ratings of personality and positive psychology constructs? We operationalized social desirability as the evaluative factor, i.e. the tendency to react to evaluative content in questionnaire items and related one standard measure and one evaluatively neutralized measure of the Big Five to measures of five key positive

Understanding Europe's Forest Harvesting Regimes

European forests are being shaped by active human use and management, and by harvesting of wood in particular. Yet, our understanding of how forests are harvested across Europe is limited, as the real harvest regimes are not well described by currently available data. Here, we analyse recent harvests, as observed in permanent plots of forest inventories in 11 European countries, totaling to 182,64

Towards a global understanding of tree mortality

Rates of tree mortality are increasing globally, with implications for forests and climate. Yet, how and why these trends vary globally remain unknown. Developing a comprehensive assessment of global tree mortality will require systematically integrating data from ground-based long-term forest monitoring with large-scale remote sensing. We surveyed the metadata from 466 865 forest monitoring plots

A comment on the physiological basis for longitudinal motion of the arterial wall

The longitudinal motion and the intramural shear strain of the arterial wall increase dramatically in response to blood pressure, thereby impacting the vascular wall microenvironment. Exposure to a sedentary lifestyle has been identified as an independent risk factor for cardiovascular disease, but it has been shown that intermittent physical activity embedded into everyday life is enough to impro

Laminarins and their derivatives affect dendritic cell activation and their crosstalk with T cells

This research explores the impact of structural variations in laminarins derived from seaweed on their immunomodulatory properties. Laminarins from Laminaria digitata, L. hyperborea, and Saccharina latissima, were obtained using a two-step water extraction protocol, followed by structural characterization by FT-IR spectroscopy, 1H NMR, and MALDI-TOF MS. The laminarin backbones were confirmed as β–

”Kraftringen har blivit en belastning för Lundaborna.”

Sveriges högsta elkostnader är resultatet av Kraftringens spretighet och dess historiskt höga benägenhet att investera i allsköns misslyckade projekt långt utanför Lunds kommungräns, skriver Lars Jonung, professor emeritus i nationalekonomi på Lunds universitet och Jan Rydenfelt, tidigare finansdirektör.

Using a Theory of Change Approach for Inclusive and Resilient Urban Food Systems in Uganda

We explore how the Resilient Urban Food Systems (RUFS) project applied a theory of change approach to raise awareness of the importance of smallholder farmers and to bring them into decision making processes, as key players working towards a sustainable and resilient food system in Kasese Municipality and Mbale City in Uganda. Critical inputs from using a theory of change approach included: consta

Did Grandmothers Enhance Reproductive Success in Historic Populations? : Testing Evolutionary Theories on Historical Demographic Data in Scandinavia and North America

Human reproductive success requires both producing children and making investments in the development of offspring. To a large extent these investments are made by the parents of the child, but researchers are now looking beyond the nuclear family to understand how extended kin, notably grandmothers, enhance reproductive success by making transfers to progeny of different kinds. The extent to whic

Microbial acidification by N, S, Fe and Mn oxidation as a key mechanism for deterioration of subsea tunnel sprayed concrete

The deterioration of fibre-reinforced sprayed concrete was studied in the Oslofjord subsea tunnel (Norway). At sites with intrusion of saline groundwater resulting in biofilm growth, the concrete exhibited significant concrete deterioration and steel fibre corrosion. Using amplicon sequencing and shotgun metagenomics, the microbial taxa and surveyed potential microbial mechanisms of concrete degra

Så funkar regnbågen

Efter regn kommer sol – och har man tur får man se en vackert lysande regnbåge. I Bibeln skapar Gud den som ett löfte om att inga fler syndafloder ska komma. I irländsk folktro finns en skatt vid regnbågens slut, och i den nordiska mytologin förbinder den människornas värld med Asgård. Men vad är regnbågen egentligen, och hur funkar den?