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Valid instrumental variables (IVs) must not directly impact the outcome variable and must also be uncorrelated with nonmeasured variables. However, in practice, IVs are likely to be invalid. The existing methods can lead to large bias relative to standard errors in situations with many weak and invalid instruments. In this paper, we derive a LASSO procedure for the k-class IV estimation methods in
Comparisons among some new types of weighted mixed regression estimators for the linear regression model under the stochastic linear restrictions have been made in this paper. The mean squared error criterion is used to examine the superiority of different weighted mixed regression estimators. A Monte Carlo simulation study and real-life application are carried out to compare the performance of th
BACKGROUND: Balloon angioplasty with drug-coated balloons (DCBs) is frequently used during percutaneous coronary intervention for in-stent restenosis. Despite its frequent use, there is a lack of long-term data on the efficacy of DCB angioplasty. We conducted an investigation on the long-term efficacy outcome of in-stent restenosis, comparing DCBs, drug-eluting stents, and plain old balloon angiop
Reduced serum level of insulin-like growth factor 1 (IGF-1), a major regulator of perinatal development, in extremely preterm infants has been shown to be associated with neurodevelopmental impairment. To clarify the mechanism of IGF-1 transport at the blood–cerebrospinal fluid (CSF) barrier of the immature brain, we combined studies of in vivo preterm piglet and rabbit models with an in vitro tra
The complex dynamics of protein expression in plasma during hyperacute HIV-1 infection and its relation to acute retroviral syndrome, viral control, and disease progression are largely unknown. Here, we quantify 1293 blood plasma proteins from 157 longitudinally linked plasma samples collected before, during, and after hyperacute HIV-1 infection of 54 participants from four sub-Saharan African cou
Håkan Hardenberger, conductor Orquesta Sinfónica de Tenerife, Ensemble Wind- and percussionworks included: Aaron Copland: Fanfare for the Common Man (1942) Irene Raquel Fariña: PhidiasErnst Krenek: Kleine Blasmusik, op. 70a IntervalEinojuhani Rautavaara: A Requiem in Our Time (1953)Antonin Dvořák: Serenade für Bläserensemble d-Moll op. 44
Andris Nelsons conducts and Håkan Hardenberger is soloist in a new trumpet concerto. Programme: Jörg Widmann Towards Paradise (Labyrinth VI) for trumpet and orchestra37 minEncore:Richard Rodgers My Funny Valentine, version for trumpet solo arr Håkan Hardenberger3 minPjotr Tjajkovskij Symphony No. 442 min
Det förvaltningsrättsliga landskapet i Sverige har under de senaste decennierna blivit allt mer sammanlänkat med Europarätten, dvs. EU-rätten, Europakonventionen samt annat material från Europarådet. För att som svensk jurist kunna arbeta med förvaltningsrättsliga frågor är det nödvändigt att ha en grundläggande förståelse för hur Europarätten påverkar de svenska rättsliga strukturerna. I verket p
Aims: The left atrial appendage (LAA) produces natriuretic peptides and its removal or occlusion might increase the risk of heart failure (HF). We aimed to investigate the incidence of HF after LAA occlusion or removal (LAAO) in the Left Atrial Appendage Occlusion Study (LAAOS III). Methods and results: Patients (n = 4811) with atrial fibrillation (AF) and a CHA2DS2-VASc score ≥2, who were having
Objective We investigated associations between bioaerosol exposures and work-shift changes in lung function and inflammatory markers among recycling workers. Methods Inhalable dust was measured with personal samplers and analyzed for endotoxin, bacteria, and fungi (incubated at 25 °C and 37 °C) levels. Lung function (FEV1, FVC) was measured before and after work-shifts and serum concentrations of
After the COVID-19 pandemic, during which teachers developed a lot of online course material, teachers worldwide are challenged with how to combine online teaching with classroom teaching in an efficient way. This paper presents Discussion seminars, a teaching activity that structures discussions clearly, making it easy for students and teachers to follow the discussion. The paper puts Discussion
Many governments worldwide have proposed transitioning from a fossil-based economy to a bioeconomy to address climate change, resource depletion, and other environmental concerns. The bioeconomy utilizes renewable biological resources across all sectors and is strongly founded on scientific advances and technological progress. Given that the bioeconomy spans multiple sectors, industries, and techn
Programme:Jörg Widmann Towards Paradise (Labyrinth VI)*Gustav Mahler Symphony No 5The trumpet concerto “Towards Paradise (Labyrinth VI)” was especially written for Håkan Hardenberger (21/22) by composer Jörg Widmann.
Extreme solar particle events (ESPEs) are infrequent yet highly potent manifestations of solar activity. These events result in the production of significant amounts of cosmogenic isotopes (CIs): 10Be, 36Cl, and 14C, which are subsequently deposited in natural stratified archives. Analyzing CI measurements from these archives allows us to assess the particle fluxes during ESPEs. In this study, we
Pulmonary veno-occlusive disease (PVOD) is a lethal variant of pulmonary hypertension. The degree of pulmonary arterial involvement varies. Here, we compare two PVOD patients who were transplanted at 8 years of age, whereof one is a homozygous EIF2AK4 mutation carrier. Tissue was imaged with synchrotron-based micro-CT and the results were compared with clinical data and sectioned tissue was analyz
The extent to which bullying victimization is associated with an increased risk of obsessive-compulsive disorder (OCD) has received little empirical attention. This longitudinal, population-based, genetically informative study examined whether self-reported bullying victimization at age 15 was associated with a clinical diagnosis of OCD in the Swedish National Patient Register and with self-report
Transverse momentum pT spectra and anisotropic flow distributions are studied for charmonia and charmed hadrons produced in Pb-Pb collisions and measured with the ALICE detector at the CERN Large Hadron Collider (LHC). The investigations are performed within the framework of the Statistical Hadronization Model with the transverse dynamics evaluated using predictions from relativistic viscous hydro
In this master's thesis a fully automated method is presented for seg-menting bones and cartilage in magnetic resonance imaging (MRI) of theknee. The knee joint is the most complex joint in the human body andsupports the weight of the whole body. This complexity and acute task ofthe knee joint leads to a disabling disease called Osteoarthritis among theadult population. The disease leads to loss o
