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Purpose: High-dose methotrexate (HDMTX) is a cornerstone in pediatric oncology, but delayed methotrexate elimination (DME) can cause severe toxicity. Rescue therapy typically combines folinic acid (FA) and glucarpidase (GP), yet current guidelines recommend pausing FA around GP administration due to presumed interference. This study aimed to determine whether FA affects GP efficacy in metabolizing
In this work, we explored the catalytic decomposition of methanol to syngas at 300 °C using intermetallic Ni3Sn2 nanoparticles (NPs) synthesized via a chemical route. Our study employed a comprehensive approach combining operando Ambient Pressure soft X-ray absorption spectroscopy with a suite of ex situ techniques─including X-ray diffraction, X-ray photoelectron spectroscopy, electron microscopy,
Road verges resemble natural bumblebee habitats in terms of flowers and nesting substrates. Hence, they may benefit bumblebee populations, especially in landscape where other floral and nesting resources are scarce. Such benefits may, however, be offset by the adjacency to traffic. As bumblebees move between habitat patches, effects on populations may manifest across landscapes rather than in the
Richard Swedberg has put the theme of “theorizing” on the international sociological agenda. The article begins by exploring the surprising parallels that can be found between Swedberg's The Art of Social Theory and the work of the Romantic writer Friedrich von Hardenberg. The thesis is that the latter's ideas about poeticization, the Romantic operation, the art of invention, experimentation, and
Ammonia is a promising carbon-free fuel for internal combustion engines (ICEs). However, existing research has not yet provided satisfactory solutions for ammonia combustion, a crucial gap that significantly limits its practical application. In this study, ammonia thermal atmosphere compression ignition (TACI) combustion mode was proposed as a promising solution to achieve efficient and clean ammo
BACKGROUND: Discordance between cystatin C- and creatinine-based estimated glomerular filtration rate (eGFR) has been linked to adverse outcomes. A low eGFRcys/eGFRcr-ratio, conceptualized as selective glomerular hypofiltration syndrome (SGHS), has been hypothesized to reflect early metabolic kidney vulnerability, although non-glomerular filtration rate determinants may also contribute. We investi
Social support is important for human well-being. Adolescents with experience of out-of-home care (OHC) have an increased risk of low well-being and lack of strong social support networks. Well-being in the general population is known to fluctuate during the life-course, particularly during adolescence. The purpose of this study was to increase our understanding of how well-being differs at differ
Take Home Message Lymph node–positive renal cell carcinoma is a heterogeneous condition. Patients with bulky or multiple nodal metastases often behave like those with metastatic disease and may benefit more from upfront systemic therapy than from surgery alone.
In this work, the electrical performance of fully vertical single-fin a-plane gallium nitride fin-based field-effect transistors (FinFETs) with short gate length (Lg≈ 200nm) and a drift-layer thickness of 4.3 µm is investigated. Device characteristics are evaluated over a temperature range from 25 °C to 150 °C for various fin widths. The FinFETs exhibit stable normally-off operation across the ent
Involving the local community in the late stages of a project offers minimal opportunity for influencing decision-making. Therefore, project managers must act early and establish arenas for participation where dialogue and learning can take place. Early involvement through stakeholder participation can be a way to involve the local community in the early stages of urban regeneration projects. A co
Aims Left ventricular (LV) function is enhanced during exercise in endurance-trained (ET) compared to untrained (UT) healthy individuals. However, the volume responses of the right ventricle (RV), left atrium (LA), and right atrium (RA) during exercise have not been studied in the same subject simultaneously and while standardizing for the respiratory influence on cardiac volumes. The aim was ther
Universitet: Lunds Universitet, Campus Helsingborg, Institutionen för Tjänstevetenskap Kurs: SEMK65- Service Management: Examensarbete för kandidatexamen Författare: Ellen Friberg & Elin Törnblom Handledare: Elisabeth Högdahl Syfte: Syftet med studien är att undersöka hur lokala aktörer uppfattar att platsidentitet kommer till uttryck genom ett återkommande evenemang, samt hur detta får betyde
Den svenska secondhandmarknaden har vuxit kraftigt under senare år och utgör idag en etablerad del av detaljhandeln. Inom golfsektorn har digitala plattformar som Golfbidder, Foremarket och Blocket gjort begagnad utrustning lättillgänglig för konsumenter, vilket förändrar förutsättningarna för golfklubbarnas egna shoppar. Trots detta saknas forskning som specifikt belyser hur golfklubbar strategis
Detta examensarbete behandlar utmattningsbedömning av åtdragningsbultar i packningsförsedda plattvärmeväxlare, med särskilt fokus på skillnaden mellan konservativa kodbaserade livslängdsprognoser och den långa livslängd som observerats i praktiken. Arbetet behandlar två utmattningsbidrag: högcyklisk driftbelastning och monteringsbelastning med större amplitud. För driftbelastningen undersöks om deThis thesis investigates fatigue assessment of tightening bolts in gasketed plate heat exchangers, with particular focus on the discrepancy between conservative code-based predictions and the long service lives observed in practice. The work addresses two fatigue contributions: high-cycle operational loading and larger-amplitude assembly loading. For the operational loading, the study examines whe
Accurate estimation of fine particulate matter (PM2.5) is essential for epidemiological exposure assessment, yet monitoring networks can be too sparse to capture spatial variation across urban areas. Existing modeling approaches address this gap using either physics-based dispersion models, which require detailed emission inventories, or machine learning models that rely on satellite aerosol optic
Wood is one of the oldest building materials used around the world. It began in more sparsely populated areas but was later established within city walls. This resulted in a factor that caused major urban fires throughout history, which sparked interest in using other building materials. However, in recent years, wood has become increasingly more attractive within the construction industry, pri
The building sector is important for Sweden’s climate mitigation efforts. Reducing emissions requires energy-efficient new buildings and sustainable renovation of existing ones. However, common envelope changes, such as thicker insulation or modified wall layers, may increase moisture accumulation and mould risk. Consequently, a comprehensive assessment of exterior walls across moisture safety, en
As the global economy fragments and geopolitical disruptions become increasingly frequent, understanding how firms strategically respond and adapt to these disruptions becomes critical. This thesis examines how A.P. Møller – Mærsk A/S has responded to geopolitical risk over time, and how these responses are indicative of organizational learning and adaptive capability development. Through a longit
This thesis examines the relationship between the climate discourse of Germany's Alternative für Deutschland (AfD) and the electoral geography of its support, asking how the party frames climate change as a threat to German identity and economic security, and whether this framing finds resonance in the districts which are most exposed to these conditions. The research addresses a gap in existi
