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Background: The introduction of vaginal natural orifice transluminal endoscopic surgery (vNOTES) to the toolbox of gynecologic surgeons has the potential to reverse the trend of vaginal hysterectomy declines. Methods: This review discusses nuances of the vNOTES technique applied to hysterectomy; describes vNOTES hysterectomy, step-by-step (including tips and tricks for low- and high-complexity cas

Background: A diagnosis of prostate cancer (PC) may cause psychosocial distress not only in a man but also in his intimate partner. However, long-term risks of depression, anxiety, or suicide in partners of men with PC are largely unknown. Methods: A national cohort study was conducted of 121 530 partners of men diagnosed with PC during 1998-2017 and 1 093 304 population-based controls in Sweden.

Long-term complications after laparoscopic ventral hernia repair with mesh reinforcement are not well documented in the literature. We describe a case of a 63-year-old woman with repeated hernia operations due to a ventral hernia, which ultimately was complicated with mesh migration into the transverse colon.

Gallbladder stones will rarely lead to colic pain attacks and even more seldom to complications. A conservative watchful waiting strategy may be an alternative to cholecystectomy for uncomplicated symptomatic gallbladder stone disease. Evidence for whether the optimal treatment should be cholecystectomy or watchful waiting is weak. This narrative-condensed review critically analyses current eviden

Heritable variation is a prerequisite for evolutionary change, but the relevance of genetic constraints on macroevolutionary timescales is debated. By using two datasets on fossil and contemporary taxa, we show that evolutionary divergence among populations, and to a lesser extent among species, increases with microevolutionary evolvability. We evaluate and reject several hypotheses to explain thi

Exoplanets in the ultra-hot Jupiter regime provide an excellent laboratory for testing the impact of stellar irradiation on the dynamics and chemical composition of gas giant atmospheres. In this study, we observed two transits of the ultra-hot Jupiter WASP-189 b with MAROON-X/Gemini-North to probe its high-altitude atmospheric layers, using strong absorption lines. We derived posterior probabilit

BACKGROUND AND AIMS: One out of three men who undergo cystoprostatectomy for bladder cancer is diagnosed with incidental prostate cancer (PCa) at histopathological examination. Many of these men are PSA tested as part of their follow-up, but it is unclear if this is needed. The aim of this study was to assess the risk of PCa death in these men and the need of PSA-testing during follow-up. METHODS:

Objective: This study aimed to report the initial experience with a novel bidirectional double cuff inner branch design for incorporation of renal and mesenteric arteries in patients undergoing fenestrated and branched endovascular aortic repair (F/BEVAR). Methods: A retrospective review was undertaken of the experience of F/BEVAR with grafts integrating at least one bidirectional double cuffed in

Experiences of loneliness are common during adolescence and previous research has shown these experiences to be related to physical and mental ill-being. However, there is limited knowledge of one kind of loneliness during adolescence–existential loneliness–which can challenge the possibilities of offering adequate support. Narrations of experiences in retrospect may lead to a deepened understandi

In 1921, after a long struggle for the right to vote, Swedish women voted in general elections for the first time. This article analyzes how election posters between 1921 and 1936 addressed and represented women. There were four types of posters. The most frequent typewas posters on which all political citizens were portrayed as men. The second type represented women as citizens with a special mis

Between 1959 and 1988, three populations of purple-flowered terrestrial orchids attributable to Dactylorhiza subgenus Dactylorhiza were discovered in Canada. The populations at Timmins, Ontario, and St John's, Newfoundland were strongly marked on both flowers and leaves, in contrast with the anthocyanin-deficient population at Tilt Cove, Newfoundland. All three populations have since experienced a

This study aimed to propose an automated prediction approach of the consolidation tumor ratios (CTRs) of part-solid tumors of patients treated with radiotherapy on treatment planning computed tomography images using deep learning segmentation (DLS) models. For training the DLS model for cancer regions, a total of 115 patients with non-small cell lung cancer (NSCLC) who underwent stereotactic body

Background: Telomere length (TL) and mitochondrial function expressed as mitochondrial DNA copy number (mtDNAcn) are biomarkers of aging and oxidative stress and inflammation, respectively. Methylmercury (MeHg), a common pollutant in fish, induces oxidative stress. We hypothesized that elevated oxidative stress from exposure to MeHg decreases mtDNAcn and shortens TL. Methods: Study participants ar

Wide-spread adoption of solar energy is a key building block in sustainable production and consumption and a circular economy. However, as the market for solar photovoltaics (PV) will grow significantly, so will the demand for raw materials and the potential waste from discarded PV panels. Based on the experience of the European CIRCUSOL innovation action project, we review recent experience in te

Breast cancer is one of the most prevalent and diverse malignancies affecting women worldwide, with an estimated 2.3 million new cases globally in 2020 alone. In Sweden, breast cancer is a major societal issue with over 8600 new diagnoses and 1300 deaths per year. It presents significant challenges in diagnosis, treatment, and prognostication due to its complex biological, molecular, and clinical

The Islamic Revolutionary Guard Corps (IRGC), established in 1979 to safeguard Iran's theocratic regime, operates independently from the nation's regular military. It focuses on both domestic security and foreign missions, notably through its specialized Quds Force. Over the years, the IRGC has evolved into a formidable force engaged in global acts of terrorism and espionage. The downing of Ukrain

För att stötta barn i deras kontakt med sociala myndigheter och stärkabarnens röster i beslut som berör dem erbjuder flera svenska barn-rättsorganisationer idag stöd till barn genom ett barnombud. I den härforskningsrapporten undersöks hur barnombuden beskriver sitt arbete– och vad vi kan lära oss av deras berättelser och de utmaningar somdet rymmer.Förutom att undersöka hur barnombudsrollen och b

For more than a decade, epidemiological surveys have shown that Taranto, Italy, has a critical health situation. In particular, two epidemiological reports have established a causal link between mortality and morbidity in Taranto and the industrial production of Ilva, one of Europe’s largest steel mills. Despite its negative impact on local health, Ilva has been allowed to produce thanks to a favo