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Revisiting bicoid function : complete inactivation reveals an additional fundamental role in Drosophila egg geometry specification

Introduction: The bicoid (bcd) gene in Drosophila has served as a paradigm for a morphogen in textbooks for decades. Discovered in 1986 as a mutation affecting anterior development in the embryo, its expression pattern as a protein gradient later confirmed the prediction from transplantation experiments. These experiments suggested that the protein fulfills the criteria of a true morphogen, with t

The use and usefulness of point-of-care tests in patients with pharyngotonsillitis – an observational study in primary health care

Background: Rapid antigen detection tests (RADT) for Group A streptococci (GAS) and point-of-care tests for C-reactive protein (CRP) are commonly used in patients with pharyngotonsillitis in Sweden and Denmark although CRP testing is not supported by guidelines. We aimed to describe (1) the proportion of patients tested with RADT and/or CRP, (2) the relation between test results and antibiotic pre

eSoil : A low-power bioelectronic growth scaffold that enhances crop seedling growth

Active hydroponic substrates that stimulate on demand the plant growth have not been demonstrated so far. Here, we developed the eSoil, a low-power bioelectronic growth scaffold that can provide electrical stimulation to the plants' root system and growth environment in hydroponics settings. eSoil's active material is an organic mixed ionic electronic conductor while its main structural component

Randomized open-label trial of semaglutide and dapagliflozin in patients with type 2 diabetes of different pathophysiology

The limited understanding of the heterogeneity in the treatment response to antidiabetic drugs contributes to metabolic deterioration and cardiovascular complications 1,2, stressing the need for more personalized treatment 1. Although recent attempts have been made to classify diabetes into subgroups, the utility of such stratification in predicting treatment response is unknown 3. We enrolled par

Kyrkorum efter branden : var god sitt - i stol eller bänk: samtida sittmöbelförändringar i svenska kyrkor

I våra kyrkor återfinns många av Sveriges mest intressanta kulturhistoriska interiörer som kan följas hundratals år bakåt i tiden. Nya idéer och former för rummets möblering och sittmöbler sker i takt med samhällets utveckling och blir nya fysiska tidslager i kyrkans narrativ. Några av vår tids stora frågeställningar har utgångspunkt i miljö, demokrati, ekonomi och hållbarhet men även arbetsmiljö,

The predictive value of highly malignant EEG patterns after cardiac arrest : evaluation of the ERC-ESICM recommendations

Purpose: The 2021 guidelines endorsed by the European Resuscitation Council (ERC) and the European Society of Intensive Care Medicine (ESICM) recommend using highly malignant electroencephalogram (EEG) patterns (HMEP; suppression or burst-suppression) at > 24 h after cardiac arrest (CA) in combination with at least one other concordant predictor to prognosticate poor neurological outcome. We evalu

Standards and Open Access are the ICOS Pillars Reply to "Comments on 'The Integrated Carbon Observation System in Europe'"

In his comment (Kowalski 2023) on our recent publication (Heiskanen et al. 2022) where we present the Integrated Carbon Observation System (ICOS) research infrastructure, Andrew Kowalski introduces three important and, in our opinion, different potential issues in the definition, collection, and availability of field measurements made by the ICOS network, and he proposes possible solutions to thes

Classics & Icons

Pop-up utställning på Gemla Galleri, Stockholm, organiserad av Möbeldesignmuseum. Utställningen visade ett antal exempel på svenska och internationella möbelklassiker från museets samling. Med utgångspunkt från Anna Wahlöös avhandling Att göra en klassiker (2017) som pågick mellan 231122-231230. .

Stress-induced BVOC emissions from forests in Sweden

Sveriges skogar påverkas av de hastiga globala klimatförändringarna. Inverkan av klimatförändringana syns redan med både ökad frekvens och kraftigare extremväder som stormar, värmeböljor, torka och skyfall. Ett tydligt exempel är den extrema torka som drabbade hela landet år 2018. Till följd av torkan har det bland annat skett en explosionsartad ökning av antalet granbarkborrar som angriper och döA changing climate is expected to lead to more extreme weather events, such as an increased frequency of droughts and forest fires. Changing forest conditions can offer benefits to species such as insects, including bark borers that thrive in warm conditions. Warmer temperatures also favor the acceleration of ozone (O3) production, which can cause stress on vegetation. Vegetation stress can have n