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Huntington’s disease is caused by a mutation in the gene that codes for the protein huntingtin (HTT). A therapeutic strategy for Huntington’s disease is to lower the levels of huntingtin in the brain. However, multiple clinical trials have been stopped due to adverse effects. This indicates that there is still a lot that we do not understand about huntingtin. Similarly to other neurodegenerative d
BackgroundRisky sexual behavior is a public health challenge that significantly affects young people’s health and well-being in Sweden and throughout the world. Moreover, poor mental health, anxiety and depression among adolescents and young adults have increased in recent years. However, although hypothesized, the associations between general mental health and risky sexual behavior among young ad
AIM: This study aims to evaluate the effect of dipeptidyl peptidase-4 inhibitors on lipid metabolism in patients with type 2 diabetes mellitus (T2D).METHODS: This is a multicenter, open-labeled, randomized controlled study. T2D patients with HbA1c 6.9-8.9% (52-74 mmol/mol) who were under treatment with sulfonylurea were randomly allocated to either the sitagliptin group or the non-sitagliptin grou
In this article, I approach the issue of stereotyping on two levels. First, methodologically, by revisiting the somewhat classical discussion on the sources of theology, discussing methods of correlation in the theologies of Paul Tillich and David Tracy, and arguing that acknowledging other religious traditions as sources of Christian theology can actually work as an antidote to theological stereo
The purpose of this article is to analyze and compare some of the popular, and yet marginalized apocalyptic narratives in contemporary Muslim and Christian thought. Obviously, the two traditions have many things in common and yet there is an apparent antagonism between them. In order to further investigate into the tensions between Muslim and Christian apocalypticism, this article will focus on ho
By relying on longitudinal data on two rural parishes in the Russian Baltic province of Livland, the article analyses two questions concerning famine's short-run effects on mortality in a manorial system: (1) whether there is evidence of a social gradient in mortality during the famine of 1844–6 and (2) whether the manors could protect the peasants against the hardships. The analysis reveals that
Carbohydrate active enzymes are valuable tools in cereal processing to valorise underutilized side streams. By solubilizing hemicellulose and modifying the fibre structure, novel food products with increased nutritional value can be created. In this study, a novel GH5_34 subfamily arabinoxylanase from Herbinix hemicellulosilytica, HhXyn5A, was identified, produced and extensively characterized
