IMPORTANCE The extent to which large-caliber axonal degeneration contributes to Alzheimer disease (AD) progression is unknown. Cerebrospinal fluid (CSF) neurofilament light (NFL) concentration is a general marker of damage to large-calibermyelinated axons. OBJECTIVE To test whether CSF NFL concentration is associated with cognitive decline and imaging evidence of neurodegeneration and white matter

Type 2 diabetes mellitus (T2DM) is an expanding global health problem, closely linked to the epidemic of obesity. Individuals with T2DM are at high risk for both microvascular complications (including retinopathy, nephropathy and neuropathy) and macrovascular complications (such as cardiovascular comorbidities), owing to hyperglycaemia and individual components of the insulin resistance (metabolic

Many primary care professionals manage injection or infusion therapies in patients with diabetes. Few published guidelines have been available to help such professionals and their patients manage these therapies. Herein, we present new, practical, and comprehensive recommendations for diabetes injections and infusions. These recommendations were informed by a large international survey of current

Breathlessness that persists despite treatment for the underlying conditions is debilitating. Identifying this discrete entity as a clinical syndrome should raise awareness amongst patients, clinicians, service providers, researchers and research funders.Using the Delphi method, questions and statements were generated via expert group consultations and one-to-one interviews (n=17). These were subs

Sponge city construction can improve cities’ ability to adapt to the environment change and the ability to cope with floods, and it can also prompt cities’ development to be more healthy and sustainable. However, the process itself of sponge city construction may also has impact on the environment especially in built-up areas, to reduce the impact, the rainwater landscape design needs to integrate

Amyloid plaques and neurofibrillary tangles (NFTs) in the brain are the neuropathological hallmarks of Alzheimer's disease (AD). Amyloid plaques are composed of β-amyloid peptides (Aβ), while NFTs contain hyperphosphorylated tau proteins. Patients with familial AD who have mutations in the amyloid precursor protein (APP) gene have either increased production of Aβ or generate more aggregation-pron

In this tutorial paper we first present some foundational results regarding the theory of positive systems. In particular, we present fundamental results regarding stability, positive realization and positive stabilization by means of state feedback. Special attention is also paid to the system performance in terms of disturbance attenuation. Under the asymptotic stability assumption, such perform

A performance-based approach is developed for adaptive robust control of linear systems with uncertain parameters. The dual control objective involves the disturbance attenuation and worst case identification of the unknown parameters. The proposed synthesis procedure relies on sufficient conditions, given in terms of suitable solutions of perturbed differential Riccati equations to exist. Althoug

Changes in the inlet morphology of choked coastal lagoons often restrict the water exchange with the sea, making them vulnerable to pollution release and eutrophication processes. In this study, the role of tides for the water exchange was investigated in a choked lagoon for critical scenarios during the low river flow season. Both an integrated and spatially distributed approach were employed usi

This article discussed the history of the position of the married woman in Dutch personal income tax law in its historical, juridical en social-cultural background. From 1892-1984 married women were in fact tax transparent in the Netherlands

A recent naturalistic epistemological account suggests that there are three nested basic forms of knowledge: procedural knowledge-how, conceptual knowledge-what, and propositional knowledge-that. These three knowledge-forms are grounded in cognitive neuroscience and are mapped to procedural, semantic, and episodic long-term memory respectively. This article investigates and integrates the neurosci

This paper argues that although solidarity was developed as a principle in EU law to enhance the unity and cooperation between the Member States, its viability at the transnational level remains ultimately a function of its efficacy at the micro level of EU citizens. The question at the core of this inquiry concerns, therefore, how micro and macro dimensions of solidarity are related to each otherThis paper argues that although solidarity was developed as a principle in EU law to enhance the unity and cooperation between the Member States, its viability at the transnational level remains ultimately a function of its efficacy at the micro level of EU citizens. The question at the core of this inquiry concerns, therefore, how micro and macro dimensions of solidarity are related to each other

In the Sustainable Development Goals era, there is a new awareness of the need for an integrated approach to healthcare interventions and a strong commitment to Universal Health Coverage. To achieve the goal of strengthening entire health systems, surgery, as a crosscutting treatment modality, is indispensable. For any health system strengthening exercise, baseline data and longitudinal monitoring