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We previously demonstrated that the overall incretin effect and the β-cell responsiveness to glucagon-like peptide-1 (GLP1) are increased in insulin-resistant mice and may contribute to the upregulated β-cell function. Now we examined whether this could, first, be explained by increased islet GLP1 receptor (GLP1R) protein levels and, secondly, be leveraged by G-protein-coupled receptor 119 (GPR119

Background: In the everyday surgical life, staff may experience that patients with Alcohol Use Disorders (AUDs) seem reluctant to participate in alcohol intervention programs. The objective was therefore to assess acceptance of screening and intervention as well as adherence to the intervention program among emergency department (ED) and surgical patients with AUDs. Methods: A systematic literatur

Granular sands are characterized and modeled here by explicitly exploiting the discrete-continuum duality of granular matter. Grain-scale kinematics, obtained by shearing a sample under triaxial compression, are coupled with a recently proposed multiscale computational framework to model the behavior of the material without resorting to phenomenological evolution (hardening) laws. By doing this, c

Collection and recycling systems for small waste electrical and electronic equipment (WEEE) in Europe has been developed based on the 2003 EU Directive on Waste Electrical and Electronic Equipment (WEEE Directive), which was transposed into the national laws of EU Member States. With the growing recognition on the potential for small WEEE to supply mateirals that are critical to the continued grow

White horses frequently suffer from malign skin cancer and visual deficiencies owing to their high sensitivity to the ultraviolet solar radiation. Furthermore, in the wild, white horses suffer a larger predation risk than dark individuals because they can more easily be detected. In spite of their greater vulnerability, white horses have been highly appreciated for centuries owing to their natural

Intradialytic hypotension is the most common acute complication during conventional hemodialysis treatment. Prediction of such events is highly desirable in clinical routine for prevention. This paper presents a novel prediction method of acute symptomatic hypotension in which the photoplethysmographic signal is analyzed with respect to changes in amplitude, reflecting vasoconstriction, and cardia

There is empirical evidence indicating that trust in research is decreasing. If distrust is justified, this is a good thing; if not, it is a cause of concern. A basic question concerns the reasons for, ant the causes of, distrust. Which are they, what do they mean, and how reliable are they? The papers and presentations in this volume focus on external and internal factors contributing to distrus

Background: It is not known whether the recently described break in the trend in hip fracture incidence in many settings applies in both women and men, depends on changes in bone mineral density (BMD) or changes in other risk factors, or whether it is apparent in both urban and rural settings. Methods: We evaluated changes in annual hip fracture incidence from 1987 to 2002 in Swedish men aged >= 6

The principal results of project 440 "Assembly and Breakup of Rodinia" of the International Geological Correlation Programme (IGCP) are reviewed in this work. A map of that supercontinent compiled using geological and paleomagnetic data describes global paleogeography 900 Ma ago. The assembly of Rodinia, which comprised most of Precambrian continental blocks, lasted ca. 400 m.y. (from 1300 to 900

With the European Commission making global leadership claims in the field of audit regulation, the content of its 2010 Green Paper on 'Audit Policy: Lessons from the Crisis' warrants careful scrutiny. Important issues raised in the Green Paper include regulatory oversight, competition in the audit market, the dangers of having very few firms with the capacity to audit global transnational corporat

The molecular and electronic structures of aqueous I-3 and I ions have been investigated through ab initio molecular dynamics (MD) simulations and photoelectron (PE) spectroscopy of the iodine 4d core levels. Against the background of the theoretical simulations, data from our I4d PE measurements are shown to contain evidence of coupled solute-solvent dynamics. The MD simulations reveal large ampl

Absorption spectra in the wavelength region around 329 nm have been recorded with the cavity ring-down technique in various low pressure (200 hPa) CH4/air flames, two of which with N2O (nitrous oxide) addition. NCN (cyanonitrene) absorption appears to be significant only in N2O-enriched flames, which also reveal spectrally nearby absorption by NH. In a phi = 1.14, N2O oxidizer volume fraction = 57

Generation of mesencephalic dopamine (mesDA) neurons from human embryonic stem cells (hESCs) requires several stages of signaling from various extrinsic and intrinsic factors. To date, most methods incorporate exogenous treatment of Sonic hedgehog (SHH) to derive mesDA neurons. However, we and others have shown that this approach is inefficient for generating FOXA2+ cells, the precursors of mesDA

Epilepsy is one of the most common neurological disorders worldwide, affecting 1% of the general population, and is characterized by a predisposition for the generation of epileptic seizures. Despite having several different aetiologies, a common underlying cause of epilepsy seems to be an acquired imbalance between excitatory and inhibitory circuits in the brain, which leads to hyperexcitability

Objective The primary objective of this study was to assess the impact of atomoxetine in combination with psychoeducation, compared with placebo and psychoeducation, on health-related quality of life (HRQL) in Swedish stimulant-naive pediatric patients with attention deficit/hyperactivity disorder (ADHD). HRQL results will be presented elsewhere. Here, psychoeducation as well as efficacy and safet