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A Prospective Observational Cohort Study on Pharmacological Habitus, Headache-Related Disability and Psychological Profile in Patients with Chronic Migraine Undergoing OnabotulinumtoxinA Prophylactic Treatment

Chronic Migraine (CM) is a disabling neurologic condition with a severe impact on functioning and quality of life. Successful therapeutic management of patients with CM is complex, and differences in therapeutic response could be attributable to genetically determined factors, sensitivity to pharmacological treatment, psychosocial and relational factors affecting the patient's compliance and appro

Health-Related Quality of Life and Psychological Features in Post-Stroke Patients with Chronic Pain: A Cross-Sectional Study in the Neuro-Rehabilitation Context of Care

This study aims at exploring disability, health-related quality of life (HrQoL), psycholog- ical distress, and psychological features in post-stroke patients with chronic pain. An observational cross-sectional study involving 50 post-stroke patients (25 with chronic pain and 25 without pain) was conducted. The primary outcome was the self-reported level of disability and HrQoL which were both asse

Is there an impact of measurable residual disease as assessed by multiparameter flow cytometry on survival of AML patients treated in clinical practice? : A population-based study

The Swedish national guidelines for treatment of acute myeloid leukemia (AML) recommend analysis of measurable residual disease (MRD) by multiparameter flow cytometry (MFC) in bone marrow in the routine clinical setting. The Swedish AML registry contains such MRD data in AML patients diagnosed 2011-2019. Of 327 patients with AML (non-APL) with MRD-results reported in complete remission after two c

Mutational spectrum of de novo NPM1-mutated acute myeloid leukemia patients older than 75 years

AML with mutated NPM1 occurs in all age groups. Yet, the mutational pattern is not extensively studied in the very old, which may hamper appropriate risk assessment. Herein we examined 22 cases of NPM1-mutated de novo AML in patients older than 75, with a median age of 84. All diagnostic samples were sequenced aiming for coverage of the most relevant AML-associated mutations. For comparison with y

Practical considerations for nonfactor-replacement therapies in the treatment of haemophilia with inhibitors

New therapeutic agents for haemophilia with inhibitors that are in development or already licensed are expected to provide transformative treatment options. Many of these new therapies are not based on simply replacing the missing factor; new strategies include bispecific antibody technology that mimics factor VIII coagulation function (emicizumab), and inhibition of anticoagulant proteins such as

Indigenous peoples land rights: A culturally sensitive strategy for poverty eradication and sustainable development

In Latin-America -as in most parts of the world- indigenous peoples are ‘the poorest of the poor, and the most excluded of the excluded’. Poverty goes hand in hand with their situation of vulnerability, exclusion and disempowerment. How can this situation be changed? How to find adequate frameworks able to facilitate the overturn of their structural disenfranchisement? Departing from the jurisprud

Introduction in the Study of Romanian Language : A textbook for foreign students

Every of the seven chapters of the course aims at introducing the students to the basics of Romanian language in the larger context of the Romanian culture and civilization development, with the ultimate purpose of settling both a few essential theoretical knowledge and some practical communication skills for the foreign students as inhabitants of Romania. The compulsory tasks at the end of each c

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It is composed following the Common European Framework of Reference for Languages (A1-B2 levels, understanding of oral and written texts). It turns to good account the composition exercises of Norwegian, Czech, Swedish and Arab students of the previous ten years teaching experience; it promotes Romanian culture and civilization landmarks; it considers probable day-to-day language understanding sit

Electric bike navigation comfort in pedestrian crowds

The emergence of electric bikes (e-bikes) has brought a paradigm shift in shared mobility with a promise to move towards the mission of sustainable cities. Whereas an in-depth understanding of e-bike riding characteristics iscrucial to effectively design the infrastructure for active mobility, it remains an open area of research. We take the first step towards modelling the e-bike navigation comfo

Building communities in times of crisis - Impacts of the COVID-19 pandemic on the work of transition intermediaries in the energy sector

The ongoing COVID-19 pandemic affects people worldwide. The policies in response to the virus range from closure of national borders to curfews for entire metropolises, like Paris. While we can expect severe impacts on the world economy, the consequences of the pandemic for local sustainability transitions are entirely unclear. In this exploratory study, we investigate how the current situation af

Biogaspotential från urbana gräsytor – Förstudie med Helsingborgs stad som case

Rapporten är en förstudie avseende potential för biogasproduktion i Helsingborg,baserad på vegetation från urbana gräsytor. Rapporten fokuserar på frågor rörande tekniska aspekter på hela kedjan, dvs. från skörd av stadsgräs till leverans av vegetationen till en biogasanläggning. Rapporten innefattar även stad-landperspektivet, och värdet av biogödseln, samt olika nyttor för urbana gräsytor genom

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Artikel i Nationalencyklopedin

Numerical simulation of solid oxide fuel cells comparing different electrochemical kinetics

Solid oxide fuel cells (SOFCs) produce electricity with high electrical efficiency and fuel flexibility without pollution, for example, CO2, NOx, SOx, and particles. Still, numerous issues hindered the large-scale commercialization of fuel cell at a large scale, such as fuel storage, mechanical failure, catalytic degradation, electrode poisoning from fuel and air, for example, lifetime in relation

A multi-input and single-output voltage control for a polymer electrolyte fuel cell system using model predictive control method

Efficient and robust control strategies can greatly contribute to the reliability of fuel cell systems, and a stable output voltage is a key criterion for evaluating a fuel cell system's reliability as a power source. In this study, a polymer electrolyte fuel cell (PEFC) system model is developed, and its performances under different operating conditions are studied. Then two different novel contr

A new model combining building block displacement and building block area reduction for resolving spatial conflicts

Applying pre-processing and geometric transformation, for the generalization of building blocks, can lead to spatial conflicts which are mainly resolved by displacement. However, the conflicts may not be resolved, due to the insufficient space for displacement or the existence of other objects that prevent displacement. This article proposes a novel model combining building block displacement and