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Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy and has a unique metastatic route using ascites, known as the transcoelomic root. However, studies on ascites and contained cellular components have not yet been sufficiently clarified. In this review, we focus on the significance of accumulating ascites, contained EOC cells in the form of spheroids, and interaction with non

I tidigare forskning om narkotika har kvinnor oftast setts som offer och medhjälpare till män, men det finns relativt lite kunskap om hur kvinnor som begår narkotikabrott agerar och resonerar kring sina upplevelser. Syftet med denna rapport är att fånga hur kvinnorna själva förklarar hur och varför de började, fortsatte och i vissa fall slutade eller fortsatt att hantera narkotika.

The assessment of entrepreneurship education outcomes should move beyond a focus on firm creation and associated economic impact to consider a more nuanced view that pays attention to graduates and their entrepreneurial competencies. There is currently limited understanding to what extent entrepreneurial competencies developed through entrepreneurship education are applied in graduates’ subsequent

crataegi Germar, 1824. The first specimen was found in the city of Malmö in the southernmost province of Sweden in the beginning of October 2020, where one individual had taken shelter from a heavy morning rain on a house wall, together with several other beetle species. The species was subsequently sought after during late autumn and winter by sifting litter beneath putative host plants, but it c

The Sun sporadically produces eruptive events leading to intense fluxes of solar energetic particles (SEPs) that dramatically disrupt the near-Earth radiation environment. Such events have been directly studied for the last decades but little is known about the occurrence and magnitude of rare, extreme SEP events. Presently, a few events that produced measurable signals in cosmogenic radionuclides

Many studies have used the relative activities of extracellular enzymes associated with microbial carbon (C), nitrogen (N) and phosphorus (P) acquisition to infer the relative C vs. nutrient limitation of the microbial community. However, recent experimental and theoretical evidence has shown that the use of ecoenzymatic ratio to infer limiting microbial resources may be invalid. We added the two

In-situ quantification of particle concentration during the combustion of solid fuel powders is of importance for analyzing their combustion behaviors. Digital holography (DH) is applied here for studying iron powder combustion at high concentration. The performance of DH as a function of particle concentration is thoroughly studied with synthetic holograms. The detection efficiency is found to be

Residues 136-159 of VPI of foot and mouth disease virus (FMDV) comprise the G-H loop of the protein and form a prominent feature on the surface of virus particles. This sequence contains an immunodominant neutralizing epitope, which can be mimicked with synthetic peptides, and includes an Arg, Gly, Asp motif which has been implicated in the binding of the virus to cellular receptors. Crystallograp

This article addresses the relation between the design of regulatory agencies and efficiency, arguing that authority concentrated to a single individual outperforms more collegial decision-making when the regulated firms’ interests are aligned. The tentative explanation is that concentrated leadership reduces the risk for capture. This argument is developed from an empirical case on the markets fo

Negative trends of climate change and biodiversity loss are closely linked with farming practices, and it is therefore essential to re-think how agricultural systems can sequester more carbon, and simultaneously create vital ecosystems. The overall aim of this research is to imagine Swedish farms as carbon sinks rather than sources, and how to re-design the current farm- and food system to also ad

This chapter explores the use of Experience Sampling Method (ESM) in a qualitative research design, departing from reflections on ontological and epistemological aspects of the tourist experience. It suggests that the tourist experience can be studied in its ordinary moments and proposes the use of ESM to capture such experience of “everydayness”. The chapter illustrates how the method can be used

The dawn of the COVID-19 pandemic in 2020 brought on an acceleration of the transition to virtual spaces in international diplomacy. Studying the virtualization of peace mediation, we describe the new conditions of hybrid peace mediation and show both advantages and challenges in comparison to traditional diplomatic face-to-face meetings. We show how virtual meetings have advantages, such as poten

The paper explores tourists’ smartphone-related information behavior on site in light of the concept of “planned serendipity”. The ability to gatherinformation at anytime and anywhere can deeply influence tourists’ behavior,their information needs and the outcomes of their travel plans. In this study, theconcept of planned serendipity is used to suggest that the outcome of travelinformation behavi

Smartphones have become one of the main tools for travel information search, especially on site, during the trip. The use of mobile technologies and ubiquitous internet connectivity do not only allow tourists to access information anywhere, at any time, but have deep impacts on tourists’ behaviours and on their whole tourist experience.The study suggests an interpretation of tourists’ information

Ribonucleotide reductase (RNR) is an essential enzyme that catalyzes the synthesis of DNA building blocks in virtually all living cells. NrdR, an RNR-specific repressor, controls the transcription of RNR genes and, often, its own, in most bacteria and some archaea. NrdR senses the concentration of nucleotides through its ATP-cone, an evolutionarily mobile domain that also regulates the enzymatic a

SQSTM1/p62 is an autophagic receptor that plays a major role in mediating stress and innate immune responses. Preclinical studies identified p62 as a target of the prototype innate defense regulator (IDR); however, the molecular mechanism of this process remains unclear. Here, we describe the structural basis and biological consequences of the interaction of p62 with the next generation of IDRs, d