The influence of astrocytes and their culturing environment on blood-brain barrier modeling in a microfluidic chip
The blood-brain barrier (BBB) is a highly selective barrier separating the brain from the circulatory system. The physical barrier is built up by a monolayer of endothelial cells, which is the main component used for in vitro modeling. To create more physiologically relevant in vitro models, the field of organs-on-chips has recently been introduced, combining microfluidics and microengineering to