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a-1-Microglobulin (A1M) is a circulating glycoprotein with antioxidant, heme-binding, and mitochondrial protection properties. The investigational drug RMC-035, a modified therapeutic A1M protein, was assessed for biodistribution and pharmacological activity in a broad set of in vitro and in vivo experiments, supporting its clinical development. Efficacy and treatment posology were assessed in var
Background: Reports of large series of hybrid iliofemoral revascularization for chronic lower limb ischemia are scarce. The aims of this study were to evaluate outcomes for staged and nonstaged procedures, and to evaluate risk factors for outcomes at 90 days. Methods: Patients were consecutively included between 2013 and 2023. Surgical site infection (SSI) was defined by the ASEPSIS criteria and m
We study the jet quenching parameter q^ in a nonequilibrium plasma using the QCD effective kinetic theory. We discuss subleading terms at large jet momentum p, show that our expression for q^ reproduces thermal results at small and large transverse momentum cutoffs for infinite p, and construct an interpolation between these limits to be used in phenomenological applications. Using simple nonequil
This study explores to what extent there is a difference in input in L1 and L2 Swedish regarding word order. Swedish is a V2 language with only one constituent preceding the tensed verb. This phenomenon is acquired in different ways by L1 and L2 learners. L1 learners produce V2 without errors around the age of two years whereas L2 learners experience long-lasting problems with the postverbal place
Second-order phase transitions appear as a divergence in one of the linear response functions. For a system of correlated electrons, the relevant divergent response can and does involve many-particle observables, most famously the double occupancy. Generally, evaluating the linear response function of many-particle observables requires a many-particle generalization of the Bethe-Salpeter equation.
Limiting global warming to 1.5 °C is crucial to prevent the worst effects of climate change. This entails also the decarbonization of the aviation sector, which is considered to be a “hard-to-abate” sector and thus requires special attention regarding its sustainability transition. However, transition pathways to a potentially climate-neutral aviation sector are unclear, with different stakeholder
Denna avhandling undersöker 1998 års svenska förbud mot sexköp utifrån den uppmärksamhet lagen fått som ett unikt tillvägagångssätt för att reglera prostitution, den starkt polariserade politiska miljö den existerar inom och de många juridiska motsägelser den uppvisar. Genom material insamlat genom en multisituerad metod mellan åren 2009 och 2019 visar studien att sexköpsförbudet är en variant av This essay thesis examines Sweden’s 1999 ban on purchasing sexual services, considering the attention it received as an unprecedented approach to governing prostitution, the highly polarised political environment in which it exists, and the multiple legal contradictions it displays. Using material gathered through a multisited method from 2009 through 2019, the study shows that the offence is a va
This study examines data-driven campaign (DDC) practices in Sweden. We explore the extent of data-driven practices adopted in Swedish political campaigns, and parties’ motivations to adopt them. Since this is a comparison of domestic parties, we test the importance of four party-level factors—resources, structure, attitudes toward data use, and ideology—using extensive interviews with key campaign
Methodological considerations in practice-based research: lessons learned from research with a music school in SwedenThis is a presentation of a practice-based research project that has been carried out in collaboration between two course leaders from a music school in Sweden and one researcher between 2022 and 2023. The aim of the research project is to contribute to knowledge about pupil particiMethodological considerations in practice-based research: lessons learned from research with a music school in SwedenThis is a presentation of a practice-based research project that has been carried out in collaboration between two course leaders from a music school in Sweden and one researcher between 2022 and 2023. The aim of the research project is to contribute to knowledge about pupil partici
In what ways can various perspectives, aims, circumstances, and directives influence music students and music teachers in different educational contexts such as primary school, Schools of music and performing arts (SMPA), folk high school, and upper secondary school, viewed from a Nordic perspective?A common characteristic for all these types of schools is that they can be part of an educational a
We perform an experimental two-color high-order harmonic generation study in argon with the fundamental of an ytterbium ultrashort pulse laser and its second harmonic. The intensity of the second harmonic and its phase relative to the fundamental are varied, in a large range compared to earlier works, while keeping the total intensity constant. We extract the optimum values for the relative phase
This chapter explores the relationship between long-term exposure to neighborhood income inequality and adult mortality in Landskrona during a period of declining economic disparities. Using geocoded data from 1939 to 1967, the authors examine three interconnected hypotheses concerning income inequality and longevity. The analysis considers spatial changes in neighborhood inequality over time and
Our book has taken a distinctive, policy-oriented approach to IGR in analysing both specific crisis-driven problems and new, longer-term, and emerging policy issues confronting European governments. We have explored the shifting balances of power within IGR systems focused on the challenges of vertical and horizontal coordination within cross-country, comparative perspectives. In order to position
Background: Involving librarians as team members can lead to better quality in reviews. To improve their search results, an international diabetes project involved two medical librarians in a large-scale project planning of a series of systematic reviews for clinical guidelines in diabetes precision medicine. Case Presentation: The precision diabetes project was divided into teams. Four diabetes m
Introduction: The long-term effects of a capitate fracture are unknown. The aim of this study was to assess both clinical and radiological long-term outcomes after a capitate fracture. Materials and methods: From a cohort of 526 consecutive patients with post traumatic radial sided wrist pain, 23 were identified diagnosed with a capitate fracture. 16 of these (11 males and 5 females) with a median
