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CONTEXT: High-quality fatigue rating scales are needed to advance the understanding of fatigue and determine the efficacy of interventions. Several fatigue scales are used in Parkinson's disease, but few have been tested using modern psychometric methodology (Rasch analysis). OBJECTIVES: To examine the measurement properties of the generic Functional Assessment of Chronic Illness Therapy-Fatigue (
The autonomic nervous system plays an important role in the regulation of the urinary bladder function. Under physiological circumstances, noradrenaline, acting mainly on beta 3-adrenoceptors in the detrusor and on a1A-adrenoceptors in the bladder outflow tract, promotes urine storage, whereas neuronally released acetylcholine acting mainly on M3 receptors promotes bladder emptying. Under pathophy
Glaciomarine clay found west of Mt Billingen, central Sweden, contains two distinct varve units separated by a sand layer that we interpret to be sediment deposited in the North Sea during the catastrophic drainage of the Baltic Ice Lake (BIL). The lower varve series was deposited proximal to the retreating ice margin and consists of varves that grade upward from gray to red. The upper varve serie
We investigated whether BMI predicts type 2 diabetes in twins and to what extent that is explained by common genetic factors. This was a population-based twin cohort study. Monozygotic (n = 4,076) and dizygotic (n = 9,109) non-diabetic twin pairs born before 1958 answered a questionnaire in 1975, from which BMI was obtained. Information on incident cases of diabetes was obtained by linkage to nati
In this study we examined ecosystem respiration (R-ECO) data from 104 sites belonging to FLUXNET, the global network of eddy covariance flux measurements. The goal was to identify the main factors involved in the variability of R-ECO: temporally and between sites as affected by climate, vegetation structure and plant functional type (PFT) (evergreen needleleaf, grasslands, etc.). We demonstrated t
Measurements of a well-characterized 'standard' sample can verify the performance of an instrument. Typically, small-angle neutron scattering instruments are used to investigate a wide range of samples and may often be used in a number of configurations. Appropriate 'standard' samples are useful to test different aspects of the performance of hardware as well as that of the data reduction and anal
Abdominal sepsis is associated with significant changes in systemic inflammation and coagulation. The purpose of this study was to examine the role of peripheral blood monocytes for systemic coagulation, including thrombin generation and consumption of coagulation factors. Abdominal sepsis was induced by cecal ligation and puncture (CLP) in C57BL/6 mice. Plasma and lung levels of interleukin-6 (IL
Background In ROCKET AF, rivaroxaban was non-inferior to adjusted-dose warfarin in preventing stroke or systemic embolism among patients with atrial fibrillation (AF). We aimed to investigate whether the efficacy and safety of rivaroxaban compared with warfarin is consistent among the subgroups of patients with and without previous stroke or transient ischaemic attack (TIA). Methods In ROCKET AF,
Predators exert strong regulating forces on lower trophic levels through predation. As most fish are visual foragers, visual conditions in the water may alter the strength of this regulation. We evaluated effects of turbidity and humic water on foraging efficiency and prey-size selectivity in Northern pike (Esox lucius) feeding on roach (Rutilus rutilus). Encounter rates decreased in both turbid a
Water-induced reorganization of individual one-dimensional J-aggregates of perylene bisimide (PBI) dyes was observed by fluorescence microscopy. Fluorescence spectra and decay kinetics of individual J-aggregates immobilized on glass surfaces were measured under a dry nitrogen atmosphere and under humid conditions. The fluorescence properties of PBI J-aggregates arisen from collective excitons unde
We introduce a new dataset, Human3.6M, of 3.6 Million 3D Human poses, acquired by recording the performance of 11 subjects, under 4 different viewpoints, for training realistic human sensing systems and for evaluating the next generation of human pose estimation models. Besides increasing the size the current state of the art datasets by several orders of magnitude, we aim to complement such datas
There is increasing evidence that hepatitis B virus (HBV) infections with different genotypes and subgenotypes differ in response to treatment and long-term prognosis. The differences emerge from variability within the genomes that leads to structural deviations at the pregenomic level and to changes at the translational level. Naturally occurring HBV strains covering the four major genotypes A-D
This study examines the dialogic functions of EXPANSION and CONTRACTION of first-person epistemic and evidential Complement-Taking Predicate (CTP) constructions, such as I think COMPLEMENT, I suppose COMPLEMENT and I know COMPLEMENT, in spoken discourse. It combines corpus and experimental methods (i) to investigate whether CTP constructions are used to open up the dialogic space for new ideas or
In this study, characterization of the binding kinetics and optimization of a magnetic permeability based point-of-care (POC) immunoassay system for quantification of canine C-reactive protein (cCRP) is described. The reagent is based on a two-site heterogeneous immunoassay system utilizing conjugated superparamagnetic nanoparticles (SPION) and silica particles, both particles carrying covalently
