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Plasmacytoid dendritic cells (pDCs) are major producers of type I/III interferons. As interferons are crucial for antiviral defense, pDCs are assumed to play an essential role in this process; however, robust evidence supporting this dogma is scarce. Genetic or pharmacological manipulations that eliminate pDCs or disrupt their interferon production often affect other cells, confounding interpretat
Solid-state electrolytes, such as lithium lanthanum zirconium oxide (LLZO), show promise as technologies for next-generation high-energy-density batteries, but commercial development has been hindered by a lack of scalable processing methods. Current fabrication methods are costly or require long annealing steps to create dense films. We report an atmospheric pressure blown-arc nitrogen plasma jet
Solar-driven hydrogen production stores renewable energy chemically but suffers from efficiency limitations due to the slow hole transport-dominated recombination, which caused by high valence band degeneracy and hole effective mass. Targeted hole trap regulation is essential to minimize these losses and enhance photocatalytic H2 evolution performance for practical applications. This study address
We explore the challenges facing the current academic training of economists in small European countries such as Sweden. The monolithic focus on publishing in the top-five journals, which prioritizes methodological rigor over problem-driven research, is often a threat to social relevance and policy applicability. This limits pluralism, excludes many talented economists, and fails to prepare gradua
This paper presents a novel approach to economic dispatch (ED) optimization in power systems through the application of Proximal Policy Optimization (PPO), an advanced reinforcement learning algorithm. The economic dispatch problem, a fundamental challenge in power system operations, involves optimizing the generation output of multiple units to minimize operational costs while satisfying load dem
We introduce lower-bound certificates for classical planning tasks, which can be used to prove the unsolvability of a task or the optimality of a plan in a way that can be verified by an independent third party. We describe a general framework for generating lower-bound certificates based on pseudo-Boolean constraints, which is agnostic to the planning algorithm used. As a case study, we show how
Employing the term “green nationalism” in the broad sense of nationalist ideologies that concern themselves with the natural environment, we trace a genealogy of green nationalist thought in Japan back to the start of the long 19th century. The changing contours of this discourse are mapped through five representative writers: Moto'ori Norinaga (1730–1801), Shigetaka Shiga (1863–1927). Testurō Wat
The aggregation of tau into amyloid fibrils is associated with Alzheimer’s disease (AD) and related tauopathies. Since different tauopathies are characterized by the formation of distinct tau fibril morphologies, it is important to combine the search of tau aggregation inhibitors with the development of in vitro tau aggregation assays that recapitulate aggregation as it may occur in the brain. Her
High-resolution transmission spectroscopy has become a powerful tool for detecting atomic and ionic species in the atmospheres of ultra-hot Jupiters. In this study, we demonstrate for the first time that the Australian-built Veloce spectrograph on the 3.9-m Anglo-Australian Telescope can resolve atmospheric signatures from transiting exoplanets. We observed a single transit of the ultra-hot Jupite
The presence of lipids after pea protein isolation was related to changes in protein structure and functionality. The aim of this study is to investigate the effects of the presence of lipids, specifically polar endogenous lipids (phospholipids), on pea globulins' (including legumin and vicilin) structure and functionality. Pea globulins were extracted by isoelectric precipitation from defatted an
Therapeutic proteins are essential in modern medicine but are often susceptible to chemical degradation during production, transportation, and storage, which can compromise functionality and even lead to immunogenicity in patients. This study investigates how the structure of the affibody GA-Z affects its chemical stability and how glycerol stabilizes the protein against deamidation and isomerizat
Svenska myndigheter ska enligt vår svenska grundlag vara fristående från regeringen. Är detta fristående tillräckligt för de krav på oberoende som EU-rätten ställer? Den frågan undersöks i detta avsnitt av Sieps Podcast.
Single-nucleus RNA sequencing enables high-resolution transcriptomic profiling of brain tissue, facilitating analysis of cell identity in models of neurodegeneration and repair. Here, we present a protocol for isolating nuclei from long-term human stem cell-derived grafts in the rat brain. We describe steps for vibratome sectioning, graft dissection, nuclear extraction, and fluorescence-activated
Multi-hazard events, though infrequent and rare, are responsible for a substantial portion of global economic losses. This book chapter investigates the complexities of multi-hazard events and explores the design challenges and methodologies in multi-hazard risk assessment and structural resilience for wooden structures. Special attention is given to the interaction between earthquakes, fires, and
Climate limits distribution of species and shows considerable regional variability. However, studies relating climate variation to species population growth rates in different climatic zones while accounting for species' ecological traits are scarce. We assessed species population responses to the main climatic constraints at a continental scale by studying how precipitation and temperature at dif
Fire safety and fire protection objectives require that buildings and parts of buildings do not collapse during a fire. This requires that the load-carrying capacity is maintained to a minimum acceptable level during a fire. This chapter briefly describes the historical background and state of the art of fire resistance and its determination for timber members through testing or calculations. The
När två oväntade silverspiror dyker upp i Kulturens magasin startar en historisk detektivresa för arkivarien Henrik Ullstad. Jakten på svar leder långt tillbaka i universitetets ceremoniella traditioner – och fram till upptäckter som utmanar den gängse bilden av dessa ikoniska föremål.
This study investigates the surface transformations of nickel foam (NF) electrodes induced by Fe and Co cation incorporation from the electrolyte following activation in the oxygen evolution reaction (OER), using both ex situ time-of-flight secondary ion mass spectrometry (TOF-SIMS) and in situ near-ambient pressure X-ray photoelectron spectroscopy (NAP-XPS). Electrochemical measurements demonstra
Philanthropy for gender causes is recognised as a rising yet understudied phenomenon, especially in the field of social policy. This chapter provides an overview of key interdisciplinary feminist debates on the philanthropic turn to gender equality and women's empowerment. It also presents significant trends, including funding flows towards SDG5, key actors, and geographical areas of investment, a
This special issue deals with temporalities in migration law with particular emphasis on the European context. At the crossroads of several legal fields, including public law, human rights law, EU law and public international law, the topic is cutting-edge in migration law. The articles collected were originally presented at a conference organized at Vrije Universiteit in Amsterdam in June 2023 an
