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Background: Any difference in biomarkers between genotype-positive individuals with overt hypertrophic cardiomyopathy (HCM), and genotype-positive but phenotype-negative individuals (G+P-) in HCM-associated pathways might shed light on pathophysiological mechanisms. We studied this in young HCM patients. Methods: 29 HCM patients, 17 G+P--individuals, and age- and sex-matched controls were prospect

The first measurement of the cross section for incoherent photonuclear production of J/ψ vector mesons as a function of the Mandelstam |t| variable is presented. The measurement was carried out with the ALICE detector at midrapidity, |y|

WEAVE, the new wide-field, massively multiplexed spectroscopic survey facility for the William Herschel Telescope, saw first light in late 2022. WEAVE comprises a new 2-deg field-of-view prime-focus corrector system, a nearly 1000-multiplex fibre positioner, 20 individually deployable ‘mini’ integral field units (IFUs), and a single large IFU. These fibre systems feed a dual-beam spectrograph cove

Kungl. Vetenskapsakademien har beslutat dela ut årets ekonomipris till Claudia Goldin (verksam vid Harvard University) ”för att ha förbättrat vår förståelse av kvinnors arbetsmarknadsutfall”. Hon var först med att ge en helhetsbild av kvinnors inkomster och deltagande på arbetsmarknaden genom århundradena. Forskningen belyser drivkrafterna bakom förändringarna och pekar på de huvudsakliga orsakern

Background: Scientific evidence is important to evidence-based practice. Hence, the application of evidence-based practice requires relevant skills and an understanding of science, which therefore need to be learned and trained during the undergraduate program in physiotherapy. The aim of this study was to investigate attitudes, perceived competence, and conditions for a scientific approach among

Objectives To determine the incidence rate (IR) of myocardial infarction (MI), relative risk of MI, and impact of incident MI on mortality in individuals with biopsy-confirmed giant cell arteritis (GCA). Methods MIs in individuals diagnosed with GCA 1998-2016 in Skåne, Sweden were identified by searching the SWEDEHEART register, a record of all patients receiving care for MI in a coronary care uni

Objectives: To describe changes in Swedish primary care physicians’ use of, attitudes and intentions toward digital tools in patient care between 2019 and 2022. Design: A survey using a validated questionnaire measuring physician’s intentions to use digital tools based on the theory of planned behavior. Setting: Sample of primary health care centers in southern Sweden. Subjects: Primary care physi

Background: Previous phase 3 studies showed that the AS01E-adjuvanted respiratory syncytial virus (RSV) prefusion F protein-based vaccine for older adults (RSVPreF3 OA) is well tolerated and efficacious in preventing RSV-associated lower respiratory tract disease in adults ≥ 60 years of age. This study evaluated lot-to-lot immunogenicity consistency, reactogenicity, and safety of three RSVPreF3 OA

Renin-secreting tumours are rare causes of secondary hypertension and hypokalaemia. They are usually surgically curable, hence proper diagnostic work-up and tumour localisation is essential. In this paper, we present three Swedish patients recently diagnosed with renin secreting tumours, two with reninomas and one with an extrarenal renin-producing tumour, to illustrate diagnostic challenges. We a

The H-abstraction reactions and disproportionation reactions play very important roles in the NH3/CH4 combustion model. The rate coefficient of the H-abstraction reaction, CH2O + NH2[dbnd]HCO + NH3 (R1430), theoretically calculated by Li & Lü was multiplied by 100 in the works of Dai et al. to better match the experiment, which was repeatedly adopted in the subsequent NH3/CH4 kinetic models. M

We construct small amplitude gravity-capillary water waves with small nonzero vorticity, in three spatial dimensions, bifurcating from uniform flows. The waves are symmetric, and periodic in both horizontal coordinates. The proof is inspired by Lortz' construction of magnetohydrostatic equilibria in reflection-symmetric toroidal domains [23]. It relies on a global representation of the vorticity a

Background: Real-world data on starting intravenous (IV) vedolizumab (VDZ) and transitioning to subcutaneous (SC) treatment in inflammatory bowel disease (IBD) are scarce. Aims: To assess treatment outcomes of patients with IBD starting IV VDZ and switching to SC VDZ in routine clinical care. Methods: Adult patients with IBD switching from IV to SC VDZ treatment between 1 March 2020 and 31 Decembe

Groundwater accounting is becoming increasingly important for sustainable societal development. To gain insights into the long-term spatiotemporal changes from 1992 to 2015 regarding groundwater resources in Kumamoto, southern Japan, we analyzed climatological time series, discharge from the groundwater-fed lake (Ezu Lake), and groundwater levels from 94 wells. To explicitly detect temporal change

This thesis addresses different aspects of atoms interacting with strong laser fields. The focus is on population and ionization dynamics occurring on ultrafast timescales, when atoms are subjected to intense extreme ultraviolet or infrared laser light. Different ways of modeling these interactions are considered. Comparisons to experimental results are performed in certain cases, and in other cas

By the Merovingian Period (6–8th century CE) a large variety of dogs and the earliest evidence of dog leashes appear in South Scandinavia. This indicates exchange, breeding and use of new types of dogs in this period. The purpose of this study is to examine the social significance and function of dogs in the Merovingian Period in South Scandinavia based on an analysis of the Nabbero ̈r boat grave By the Merovingian Period (6–8th century CE) a large variety of dogs and the earliest evidence of dog leashes appear in South Scandinavia. This indicates exchange, breeding and use of new types of dogs in this period. The purpose of this study is to examine the social significance and function of dogs in the Merovingian Period in South Scandinavia based on an analysis of the Nabberör boat grave on

Business Process Modeling, Simulation and Design, Third Edition provides students with a comprehensive coverage of a range of analytical tools used to model, analyze, understand, and ultimately design business processes.The new edition of this very successful textbook includes a wide range of approaches such as graphical flowcharting tools, cycle time and capacity analyses, queuing models, discret

High-density lipoproteins (HDLs) are responsible for removing cholesterol from arterial walls, through a process known as reverse cholesterol transport. The main protein in HDL, apolipoprotein A-I (ApoA-I), is essential to this process, and changes in its sequence significantly alter HDL structure and functions. ApoA-I amyloidogenic variants, associated with a particular hereditary degenerative di

Soft materials are usually defined as materials made of mesoscopic entities, often self-organised, sensitive to thermal fluctuations and to weak perturbations. Archetypal examples are colloids, polymers, amphiphiles, liquid crystals, foams. The importance of soft materials in everyday commodity products, as well as in technological applications, is enormous, and controlling or improving their prop