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The exponential growth of converging technologies, including augmented reality, autonomous vehicles, machine-to-machine and machine-to-human interactions, biomedical and environmental sensory systems, and artificial intelligence, is driving the need for robust infrastructural systems capable of handling vast data volumes between end users and service providers. This demand has prompted a significa
Repair practices are driven not only by consumers’ internal motivation, but also by external infrastructural, social including cultural, financial, and political factors. We explore these factors with the goal of understanding the public repair of electrical and electronic products (e-products) from a systems perspective to help devise appropriate change interventions. We document (a) behavioral a
Eyes in low-light environments typically must balance sensitivity and spatial resolution. Vertebrate eyes with large "pixels" (e.g., retinal ganglion cells with inputs from many photoreceptors) will be sensitive but provide coarse vision. Small pixels can render finer detail, but each pixel will gather less light, and thus have poor signal relative-to-noise, leading to lower contrast sensitivity.
This article analyzes how the relationship between philosophy and history has been conceived within the study of political thought, and how different ways of conceiving this relationship in turn have affected the definition of the subject matter as well as the choice of methods within this field. My main argument is that the ways in which we conceive this relationship is dependent on the assumptio
Non-lethal infections are common in free-living animals and the associated sickness behaviours can impact crucial life-history trade-offs. However, little is known about the duration and extent of such sickness behaviours in free-living animals, and consequently how they affect life-history decisions. Here, free-living Eurasian blackbirds, Turdus merula, were immune-challenged with lipopolysacchar
Background: The complement system seems to influence cancer pathophysiology. The primary aim of this study was to explore complement components associated with the classical pathway (CP) of the complement system in peripheral blood from patients with IDH–wild-type (IDH-wt) glioblastoma. Methods: Patients undergoing primary surgery due to glioblastoma in the years 2019–2021 were prospectively inclu
Atherosclerosis, the underlying pathology of cardiovascular diseases such as myocardial infarction and ischemic stroke, is characterized by chronic inflammation. T cells are present in atherosclerotic plaques and have been implicated in its pathogenesis. This thesis describes studies exploring both the regulation of T cells in atherosclerosis as well as immunomodulatory therapeutics. To study the
The amyloid cascade hypothesis has strongly impacted the Alzheimer's disease research agenda and clinical trial designs over the past decades, but precisely how amyloid-β pathology initiates the aggregation of neocortical tau remains unclear. We cannot exclude the possibility of a shared upstream process driving both amyloid-β and tau in an independent manner instead of there being a causal relati
Air concentrations of polycyclic aromatic compounds (PACs) were measured in a Norway spruce (Picea abies) stand at four different distances from a major traffic route near Gothenburg, Sweden, during summer and winter 2019, using passive samplers. In total, the concentrations of 32 polycyclic aromatic hydrocarbons (PAHs) and six dibenzothiophenes (DBTs) and NO2 were analysed. PAC air concentrations
Climate change and eutrophication are two environmental threats that can alter the structure of freshwater ecosystems and their service functions, but we know little about how ecosystem structure and function will evolve in future scenarios of climate warming. Therefore, we created different experimental climate scenarios, including present-day conditions, a 3.0 °C increase in mean temperature, an
Stock and bond are the two most crucial assets for portfolio allocation and risk management. This study proposes generalized autoregressive score mixed frequency data sampling (GAS MIDAS) copula models to analyze the dynamic dependence between stock returns and bond returns. A GAS MIDAS copula decomposes their relationship into a short-term dependence and a long-term dependence. While the long-ter
The tropical Pacific Ocean plays a significant role in climate change, and the El Niño-Southern Oscillation (ENSO) is considered to be closely related to extreme climate phenomenon worldwide. However, the evolution of the ENSO-like patterns in the tropical Pacific during the Pleistocene glacial cycles remains controversial. In this study, we present geochemical indices and a transient model simula
Background: The identification of biomarkers that reflect worse progression of nonmotor symptoms (NMS) in Parkinson's disease (PD) is currently an unmet need. The main aim of this study was to investigate whether cerebrospinal fluid (CSF) and serum neurofilament light (NfL), measured at baseline or longitudinally, can be used to predict the progression of NMS in patients with PD. Methods: Baseline
Objective: To investigate how a behavioral health, artificial intelligence (AI)-powered, digital self-management tool affects the daily functions in adults with chronic back and neck pain. Design: Eligible subjects were enrolled in a 12-week prospective, multicenter, single-arm, open-label study and instructed to use the digital coach daily. Primary outcome was a change in Patient-Reported Outcome
New Zealand's largest city, Auckland, is situated within the basaltic Auckland Volcanic Field (AVF). Therefore, understanding the eruption history of the local volcanoes in the field is of great importance in order to assess future hazards that they may pose. Rangitoto is the youngest and largest volcano in the AVF, although the timing of the first eruption and the duration of the volcanic activit
Deep decarbonisation of extractive and foundational industries will involve widespread social and economic change. Research on previous industrial restructuring has demonstrated that resultant changes will be geographically uneven, especially without countervailing state intervention. Such change has been shown to matter for both the nature and location of work in those industries as well as for t
The positive effects of nature on people's mental health are not only relevant for boosting their lifestyles, but could also play a role in the treatment of mental illness. To this end, the following systematic review investigates whether ecotherapy can achieve similar success as conventional cognitive-behavioral psychotherapy with regard to the treatment of depression and anxiety disorders, and w
