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Objective To investigate the effect of Body Mass Index (BMI) on long-term radiographic damage in an inception rheumatoid arthritis (RA) cohort. Methods The study population, n=1813, originated from the observational Better AntiRheumatic FarmacoTherapy cohort. X-rays of hands and feet at inclusion, 1, 2, 5, 8 and 15 years were quantified for erosion score (ES), joint space narrowing (JSN) and the s
Aberrant protein aggregation into amyloid fibrils is often catalyzed by interfaces. Therefore, it is important to characterize the surface activity of chaperone proteins having the ability to suppress amyloid formation. The air–water interface is of large practical significance in experimental setups used to study aggregation kinetics in vitro, but in addition, the binding of chaperones to hydroph
Introduction: Dislocation is a major complication of total hip arthroplasty (THA) for femoral neck fractures (FNFs). Dual mobility cups (DMCs) are in clinical practice for patients at risk of dislocation in primary-and revision arthroplasty. This study investigated whether changing routines from conventional THA (cTHA) to DMC for fracture patients at our orthopaedic unit resulted in a reduced disl
Stage- and lineage-specific gene expression patterns are controlled by a complex interplay between transcription factors, the epigenetic landscape, and the three-dimensional (3D) structure of the DNA. The 3D structure allows for the formation of DNA loops that juxtaposition distal regulatory elements to the promoters, allowing for tight control of gene expression. Developing a tool to facilitate t
Breakthroughs in battery research are imperative to provide society with batteries that are safe and sustainable, have a high energy density, and have a long cycle life at low cost. Recent advances in research methodologies, the emergence of new market opportunities, and strategic funding schemes have allowed not only large, but also small companies, universities, and public research organizations
The hydrogenation of CO2 into methanol by a nickel pincer catalyst has been studied in both aqueous and solid–gas phases. Hydrogenation occurs at the moderate temperatures of 60–95 °C. The solid–gas phase reaction is found to be more efficient than the aqueous reaction. At 95 °C and 1 MPa of H2/CO2 (3:1), 18 μmol of methanol is generated in the optimized solid–gas phase reaction versus 10 μmol in
Policy on greening freight constitutes a recent addition to the discourse on sustainability in the EU. To stimulate economic growth, the EU also plans for freight transport activity to grow significantly over the coming decades. In this paper, drawing on critical discourse analysis and Marxian geographical thought, I show how the argument for implementing sustainable freight is constructed in EU fPolicy on greening freight constitutes a recent addition to the discourse on sustainability in the EU. To stimulate economic growth, the EU also plans for freight transport activity to grow significantly over the coming decades. In this paper, drawing on critical discourse analysis and Marxian geographical thought, I show how the argument for implementing sustainable freight is constructed in EU f
Aerosol surface composition plays a critical role in atmospheric chemistry but remains poorly characterized, especially for inorganic systems lacking organic surfactants. While bulk composition is typically measured, key interfacial processes, including heterogeneous reactions, water uptake, and cloud activation, occur at the surface. Here, we present the first depth-resolved, in-flight X-ray phot
Adaptive reuse of buildings, repurposing existing structures for new functions, is gaining attention for its potential in sustainable development and optimisation of building materials usage. This practice is particularly relevant in the building sector, where space heating, ventilation, and air conditioning (HVAC) systems represent a significant portion of project costs, embodied energy, greenhou
The traditional approaches rely solely on temperature measures to assess heat-related health risks; but there is a growing trend towards using bio-meteorological indices for a more comprehensive evaluation. However, the adoption of bio-meteorological indices in developing countries is considerably limited. Therefore, this study compares bio-meteorological index, the maximum Universal Thermal Clima
Overdischarge poses severe challenges to the structural integrity and electrochemical performance of layered LiNixCoyMn1-x-yO2 (NCM) cathodes in lithium-ion batteries, yet the underlying degradation mechanisms remain insufficiently understood. Through a combined experimental and theoretical approach, this study systematically investigates how overdischarge destabilizes NCM cathodes with varying tr
Layered lithium-rich transition metal oxides are promising cathode candidates for high-energy-density lithium batteries due to the redox contributions from transition metal cations and oxygen anions. However, their practical application is hindered by gradual capacity fading and voltage decay. Although oxygen loss and phase transformation are recognized as primary factors, the structural deteriora
Rechargeable magnesium batteries are promising for future energy storage. However, among other challenges, their practical application is hindered by low coulombic efficiencies of magnesium plating and stripping. Fundamental processes such as the formation, structure, and stability of passivation layers and the influence of different electrolyte components on them are still not fully understood. I
Anode-free zinc batteries offer reduced weight and simplified production compared to traditional zinc metal batteries, but challenges such as dendrite formation and parasitic reactions limit their efficiency and cycle life. In this study, we present an effective strategy to form a zincophilic interphase in situ via indium co-deposition during cycling, using InCl3 as an electrolyte additive. Zinc p
Aqueous lithium-ion batteries (ALIBs) are promising for large-scale energy storage systems because of the cost-effective, intrinsically safe, and environmentally friendly properties of aqueous electrolytes. Practical application is however impeded by interfacial side-reactions and the narrow electrochemical stability window (ESW) of aqueous electrolytes. Even though higher electrolyte salt concent
Aqueous zinc-bromine (Zn-Br2) batteries feature operational safety and high-energy and high-power densities, but suffer from polybromide dissolution in the cathode and the low reversibility of Zn metal in the anode. Here, we demonstrate that these challenges can be simultaneously tackled by using a fully exploited imidazolium bromide (MPIBr). An in-depth analysis demonstrates that MPIBr enhances b
The binder plays a crucial role in maintaining the integrity and enhancing the conductivity of the electrode, although it accounts for a small weight fraction in the entire electrode. However, the conventional binder used in lithium-sulfur (Li-S) batteries fails to effectively tackle the challenges posed by the shuttle effect of lithium polysulfides, as well as the issues of poor conductivity and
Rechargeable magnesium batteries could provide future energy storage systems with high energy density. One remaining challenge is the development of electrolytes compatible with the negative Mg electrode, enabling uniform plating and stripping with high Coulombic efficiencies. Often improvements are hindered by a lack of fundamental understanding of processes occurring during cycling, as well as t
The practical application of aqueous rechargeable batteries faces several challenges due to the limited stability window of electrolytes and parasitic side reactions, such as corrosion, passivation, gas evolution, and co-intercalations. The solid electrolyte interphase (SEI) formed at the electrode/electrolyte interface plays a critical role in determining interfacial properties and battery perfor
