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Translation of novel discoveries to human disease is limited by the availability of human tissue-based models of disease. Precision-cut lung slices (PCLS) used as 3D lung tissue cultures (3D-LTCs) represent an elegant and biologically highly relevant 3D cell culture model, which highly resemble in situ tissue due to their complexity, biomechanics and molecular composition. Tissue slicing is widely
The HER2 oncogene and its truncated form p95HER2 play central roles in breast cancer. Here, we show that although HER2 and p95HER2 generally elicit qualitatively similar changes in miRNA profile in MCF-7 breast cancer cells, a subset of changes are distinct and p95HER2 shifts the miRNA profile towards the basal breast cancer subtype. High-throughput miRNA profiling was carried out 15, 36 and 60 h
Large herbivores can control plant community composition and, under certain conditions, even induce vegetation shifts to alternative ecosystem states. As different plant assemblages maintain contrasting carbon (C) cycling patterns, herbivores have the potential to alter C sequestration at regional scales. Their influence is of particular interest in the Arctic tundra, where a large share of the wo
That export-led industry sets the wage norm for the whole economy, acting as the “wage leader”, is a celebrated part of the Swedish wage bargaining and labour market model. Export- led wage leadership is assumed to lead to controlled, non-inflationary wage increases, as wages are set with international competition in mind. This paper maps the origins of this export industry wage leadership model,
The migration strategies of smaller, south European, Mediterranean birds are less well known than those of northern and central European birds. We used geolocators to map individual spatiotemporal migration schedules of three species breeding in the Iberian Peninsula: The White-rumped Swift Apus caffer, rufous-tailed Scrub-robin Cercotrichas galactotes and Bluethroat Cyanecula svecica. The three s
Multifractal (MF) analysis is applied for the description of spatial nanoforms which form a relief on a surface of heterostructures of ZnxCd1-xTe solid solution – substrate Si (1 1 1) synthesized by the method of the electron beam with the evaporating anode. The input data for the MF analysis were the AFM (atomic force microscopy) images of the surface of layers. Comparison of parameters of MF spe
The multifractal (MF) analysis of the surface areas and the volumes of fuel spray droplet imprints, which formed on the surface of a glass plate covered with a soot layer, is presented. The input information for the MF analysis was obtained from photographic images of imprints of droplets of biodiesel, diesel and their mixtures. The parameters for the MF spectra of the surface areas and the volume
Multifractal (MF) analysis is used to describe volumes of spatial forms that are formed on the surface of thin layers of ZnxCd1−xTe solid solution grown on the Si (111) substrate. MF analysis is performed on the basis of AFM images of the solid solution surface. The parameters of the MF spectrums for the distribution of volumes of the spatial forms, which formed the surface relief, were found. On
Compared to the United States, the relationship between ethnicity and gentrification is still understudied in the Western European context. However, while Western Europe does not have the same racial history as the United States, ethnic and racial divisions are still expressed through urban inequality. This paper, a study of small-business owners in an ethnically stigmatized Berlin neighborhood, s
There are important unresolved questions about long-term trends of in- novation activity and the nature of the interplay between innovation and economic development and transformation. This study explores the promise of a literature-based innovation output indicator, constructed for the Swedish engineering industry, 1909-2016. The findings suggest a long-run increasing trend in innovations per cap
Estimates of relative pollen productivity (RPP) represent key input parameters for model-based quantitative reconstructions of past vegetation cover. In this study, we provide the first RPP estimates for 13 taxa from the forest steppe ecoregion in southeastern Romania (southeastern Europe). We used modern pollen assemblages from 26 points together with vegetation surveys and mapping, covering a 1.
