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Protein dynamics: aggregation and mechanical unfolding

The subject of this thesis is protein dynamics. Papers I--IV and VI study either of two different processes: mechanical unfolding and aggregation. Paper V presents a computationally efficient all-atom model for proteins, variants of which are used to perform Monte Carlo simulations in the other papers. Mechanical unfolding experiments probe properties of proteins at the single molecule level. The

Self-reported mindfulness mediates the relation between meditation experience and psychological well-being

A well established notion in Buddhist literature is that meditation practice improves the ability to be mindful in daily life which in turn promotes psychological wellbeing. In order to test this hypothesis the relations between meditation experience, five mindfulness facets and psychological well-being were studied in a sample consisting of Buddhist meditators, Western mindfulness meditators and

Molecular co-operation between protein PAM and streptokinase for plasmin acquisition by Streptococcus pyogenes.

Bacterial surface-associated plasmin formation is believed to contribute to invasion, although the underlying molecular mechanisms are poorly understood. To define the components necessary for plasmin generation on group A streptococci we used strain AP53 which exposes an M-like protein ("PAM") that contains a plasminogen-binding sequence with two 13-amino acid residues long tandem repeats (a1 and

State of the art of sensor technology

Literature surveys, limited to the sensor technologies applicable for the functionalities of relevance for the “Safe Speed” and “Safe Distance” concept, were conducted on recent and undergoing development in the area of sensor technology. Various alternatives of combinations of sensors can serve for building the prototype for the Safe Speed and Safe Distance concept. However, one sensor alone can

The Structure of Intelligence, The intelligence informations management needs of an NGO operation in the light of the MIP interoperability data model

During the establishmen of an NGO Maritime Rescue Service (MRS)in the Lake Albert region in Uganda, the intelligence information management (IM) needs of the operation cere compared with earlier IM experiences of a combined peace keeping mission. This paper describes the MRS oparation IM needs. Furthermore, the Joint Command and Control Information Exchange Data Model (JC3IEDM) is introducea as th

Development of techniques for light isotope analysis at LIBAF

Popular Abstract in Swedish Jonstråleanalys är ett fält inom tillämpad fysik vars utövare sysselsätter sig med bestrålning av olika föremål med joniserande strålning från partikelacceleratorer. Fysiker och kemister observerade i början av nittonhundratalet att joniserande strålning såsom alfapartiklar från radioaktiva källor ger upphov till olika sorters strålning när den växelverkar med materiThe overall goal of this thesis is to test new detector technologies and data acquisition systems, for use in Ion Beam Analysis IBA. This is intended to complement the existing setup, which is routinely used at Lund Ion beam Analysis Facility LIBAF. Proton induced X-ray emission is a well-known method for trace element analysis of heavier elements, but trace element analysis of elements below alum

Knowledge Representation and Planning Strategies for Batch Plant Operating Procedure Synthesis

Synthesis of operating procedures for batch plants involves systematic generation of step by step instructions which the operator can implement to manage the batch plant safely and optimally. This is a labor and knowledgeintensive task. It often takes weeks of effort by experts to prepare a clear and error free set of instructions even for a moderately complex plant. If this process is automated,