Polymer solutions in the dilute regime play a significant role in industrial applications. Due to the intricate rheological properties of these highly viscoelastic fluids, especially in complex flow geometries, a thorough numerical analysis of their flow dynamics is imperative. In this research, we present a numerical investigation of purely elastic instability occurring in two- and three-dimensio

Elastic turbulence has emerged as a promising method to enhance heat transfer performance at the microscale. However, previous studies have mainly focused on the overall convective heat transfer performance in curved channels, overlooking the fact that the chaotic flow intensity varies along the streamline, leading to diverse local heat transfer characteristics. In this study, we systematically in

We numerically investigate the spatial and temporal statistical properties of a dilute polymer solution in the elastic turbulence regime, i.e., in the chaotic flow state occurring at vanishing Reynolds and high Weissenberg numbers. We aim at elucidating the relations between measurements of flow properties performed in the spatial domain with the ones taken in the temporal domain, which is a key p

The aggregation properties of heavy inertial particles in the elastic turbulence regime of an Oldroyd-B fluid with periodic Kolmogorov mean flow are investigated by means of extensive numerical simulations in two dimensions. Both the small- and large-scale features of the resulting inhomogeneous particle distribution are examined, focusing on their connection with the properties of the advecting v

Deciphering the genetic basis of prostate-specific antigen (PSA) levels may improve their utility for prostate cancer (PCa) screening. Using genome-wide summary statistics from 95,768 PCa-free men, we conducted a transcriptome-wide association study (TWAS) to examine impacts of genetically predicted gene expression on PSA. Analyses identified 41 statistically significant (p < 0.05/12,192 = 4.10×10

Toxin-antitoxins (TAs) are prokaryotic two-gene systems composed of a toxin neutralized by an antitoxin. Toxin-antitoxin-chaperone (TAC) systems additionally include a SecB-like chaperone that stabilizes the antitoxin by recognizing its chaperone addiction (ChAD) element. TACs mediate antiphage defense, but the mechanisms of viral sensing and restriction are unexplored. We identify two Escherichia

Toxic small alarmone synthetase (toxSAS) enzymes constitute a family of bacterial effectors present in toxin-antitoxin and secretion systems. toxSASs act through either translation inhibition mediated by pyrophosphorylation of transfer RNA (tRNA) CCA ends or synthesis of the toxic alarmone adenosine pentaphosphate ((pp)pApp) and adenosine triphosphate (ATP) depletion, exemplified by FaRel2 and FaR

BACKGROUND: Platelet transfusions are frequently used in the intensive care unit (ICU), but current practices including used product types, volumes, doses and effects are unknown.STUDY DESIGN AND METHODS: Sub-study of the inception cohort study 'Thrombocytopenia and Platelet Transfusions in the ICU (PLOT-ICU)', including acutely admitted, adult ICU patients with thrombocytopenia (platelet count

BACKGROUND: Finding ways to prolong independence in daily life among older people would be beneficial for both individuals and society. Urban green spaces have been found to improve health, but only a few studies have evaluated the association between urban green spaces and independence in daily life. The aim of this study was to assess the long-term effect of urban green spaces on independence in

Behavioural science methods have significant potential to help policy makers, practitioners and energy programme managers design, implement and evaluate behavioural campaigns addressing hard-to-reach (HTR) energy users. But when facing budget and logistic constraints, how many real-life programmes actually follow through? How are behavioural science methods actually applied in a real-world setting

In this chapter, we argue that policy-making aiming to achieve environmentally sustainable transitions of the economy is in need of a solid empirical evidence base. Conventional measurement concepts used for example by the EU based on sector-classifications deliver highly biased pictures. We propose measurement concepts based on the use of green skills and human capital, validate key assumptions o

This study investigates the first films made by a female director, Kangdrun (T: Gangs sgron, གངས་ྒྲསྒྲོན་, Gangzhen, 岗珍, b. 1995) belonging to the Post-2000s Inland Tibet Class (ITC) generation. Following the experience of the Sinophone-Tibetan filmmaker Kangdrun in a Chinese language education environment, her films, and Tibetan cultural communities, this study discusses Kangdrun’s visual strateg

In the us, test score gaps by socioeconomic status and race increase with city size. This paper examines to what extent residential sorting on school quality can explain this fact. We combine 15 years of data on public elementary school studentsin North Carolina with geocoded school locations and proxy city size with a measure of school density in a local labor market. Assortative matching between