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Prediction of Chemical Respiratory Sensitizers Using GARD, a Novel In Vitro Assay Based on a Genomic Biomarker Signature.

Repeated exposure to certain low molecular weight (LMW) chemical compounds may result in development of allergic reactions in the skin or in the respiratory tract. In most cases, a certain LMW compound selectively sensitize the skin, giving rise to allergic contact dermatitis (ACD), or the respiratory tract, giving rise to occupational asthma (OA). To limit occurrence of allergic diseases, efforts

MAPK signaling pathway regulates cerebrovascular receptor expression in human cerebral arteries

Background: Cerebral ischemia results in enhanced expression of contractile cerebrovascular receptors, such as endothelin type B (ETB), 5-hydroxytryptamine type 1B (5-HT1B), angiotensin II type 1 (AT(1)) and thromboxane (TP) receptors in the cerebral arteries within the ischemic area. The receptor upregulation occurs via activation of the mitogen-activated protein kinases (MAPK) pathway. Previous

Multiplex detection of human herpesviruses from archival specimens by using matrix-assisted laser desorption ionization-time of flight mass spectrometry.

The human herpesviruses are involved in a variety of diseases. Large-scale evaluation of the clinical and epidemiological importance of different herpesviruses requires high-throughput methods. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a method that has a multiplex capacity enabling simultaneous detection of several viruses in a single sample. P

Endovascular and open surgery for acute occlusion of the superior mesenteric artery

Background: Acute thromboembolic occlusion of the superior mesenteric artery (SMA) is associated with high mortality. Recent advances in diagnostics and surgical techniques may affect outcome. Methods: Through the Swedish Vascular Registry (Swedvasc), 121 open and 42 endovascular revascularizations of the SMA at 28 hospitals during 1999 to 2006 were identified. Patient medical records were retriev

Colloidal particles composed of amphiphilic molecules binding gadolinium complexes and peptides as tumor-specific contrast agents in MRI: physico-chemical characterization

This article highlights our recent achievements on the development and upgrade of new potential tumor-specific contrast agents for magnetic resonance imaging (MRI) based on gadolinium complexes and peptides, assemblied in amphiphilic supramolecular aggregates. The physico-chemical characterization of these aggregates provides novel and interesting opportunities to investigate surfactant aggregatio

The God Question

The essay focuses on the apophatic tradition, Western metaphysics, and the unknown God. It presents Jaspers' thoughts on transcendence as an eye-opener. To take the issue of the unknown God, two philosophers are highlighted, David Hume and Simone Weil. For Hume the concept of the unknown God presents the problem of how might anything that is unknown have any moral influence on human beings? Simone

Real-Time Camera Tracking and 3D Reconstruction Using Signed Distance Functions

The ability to quickly acquire 3D models is an essential capability needed in many disciplines including robotics, computer vision, geodesy, and architecture. In this paper we present a novel method for real-time camera tracking and 3D reconstruction of static indoor environments using an RGB-D sensor. We show that by representing the geometry with a signed distance function (SDF), the camera pose

Model Order Reduction Based on Semidefinite Programming

The main topic of this PhD thesis is complexity reduction of linear time-invariant models. The complexity in such systems is measured by the number of differential equations forming the dynamical system. This number is called the order of the system. Order reduction is typically used as a tool to model complex systems, the simulation of which takes considerable time and/or has overwhelming memory

Review of particle physics

This biennial Review summarizes much of particle physics. Using data from previous editions., plus 2778 new measurements from 645 papers, we list, evaluate, and average measured properties of gauge bosons, leptons, quarks, mesons, and baryons. We also summarize searches for hypothetical particles such as Higgs bosons, heavy neutrinos, and supersymmetric particles. All the particle properties and s

Pair correlations, short-range order, and dispersive excitations in the quasi-kagome quantum magnet volborthite

We present spatial and dynamic information on the s = 1/2 distorted kagome antiferromagnet volborthite, Cu3V2O7(OD)(2) center dot 2D(2)O, obtained by polarized and inelastic neutron scattering. The instantaneous structure factor, S(Q), is dominated by nearest-neighbor pair correlations, with short-range order at wave vectors Q(1) = 0.65(3) angstrom(-1) and Q(2) = 1.15(5) angstrom(-1) emerging belo

Multiple Antenna Terminals in Realistic Environments - A Composite Channel Modeling Approach

Popular Abstract in Swedish Mobiltelefonanvändandet förändrades radikalt för några år sedan när de nya grafiska ”touchmobilerna” lanserades och mobilt internet blev inte bara tillgängligt utan också enkelt och använbart för alla. Idag är en ”smart-phone” i det närmaste obligatorisk i handen på såväl vuxna som ungdomar och kraven på datatakt och åtkomst är höga och ökar när allt fler samtidigt anväFor evaluation of specific antenna arrangements in wireless communication systems we need physical channel models that take into account also the directional domain of the propagation channel. In this thesis we investigate, validate and propose a practical approach to wireless channel modeling and, particularly, to mobile communication systems. For this we make the assumption that the channel can

Beyond the Catchwords : Adjustment and Community Response to Participatory Development in Post-Suharto Indonesia

Popular Abstract in Swedish Folkligt deltagande är något av en paroll i dagens utvecklingstänkande. När människor deltar i beslutsfattande och samhällsplanering på lokal nivå blir resultatet bättre och mer anpassat till lokala behov, särskilt i jämförelse med expertorienterade och centraliserade utvecklingsstrategier. Samtidigt kräver detta att folk i allmänhet vill delta och de har ett intresse aThe emphasis on people-centred development is distinctive in today’s development discourse. This is noticeable in catchwords like democratic decentralisation, participation, and empowerment, which are highly esteemed among NGOs, donors, and policymakers in recipient countries. The benefits of participatory approaches are several. When people influence the process of development, policies and pro

Investigation of Type 2 Diabetes Risk Alleles Support CDKN2A/B, CDKAL1, and TCF7L2 As Susceptibility Genes in a Han Chinese Cohort

Background: Recent genome-wide association studies (GWASs) have reported several genetic variants to be reproducibly associated with type 2 diabetes. Additional variants have also been detected from a metaanalysis of three GWASs, performed in populations of European ancestry. In the present study, we evaluated the influence of 17 genetic variants from 15 candidate loci, identified in type 2 diabet

Factors Associated With Maternal-Reported Actions to Prevent Type 1 Diabetes in the First Year of the TEDDY Study

OBJECTIVEMothers of children at risk for type 1 diabetes report engaging in preventive behaviors. The purpose of this study is to further document these actions in an international, longitudinal sample and examine variables that predict whether mothers engage in these behaviors.RESEARCH DESIGN AND METHODSThis study examined an international sample (from Finland, Germany, Sweden, and the U.S.) from

Gastrointestinal motility and the role of gonadotropin-releasing hormone (GnRH)

Popular Abstract in Swedish Könshormon påverkar tarmrörelser Många av kroppens funktioner styrs av hormoner. Att hormoner som vi i första hand förknippar med fortplantning också skulle kunna spela en avgörande roll för tarmfunktion är dock en relativt ny upptäckt. Få saker är så viktigt för en människas välbefinnande som en välfungerande magtarmkanal. De flesta av oss tänker inte på att frukostfrThis thesis explores the relation between gonadotropin-releasing hormone (GnRH) and gastrointestinal symptoms and dysmotility. In primary Sjögren’s syndrome (pSS), a patient group with high levels of GnRH antibodies, associations between objective signs and symptoms of autonomic dysfunction (AD), impaired gastric emptying (IGE), and inflammatory and serological features were studied. Forty-three

Effects of nutrients and fish on periphyton and plant biomass across a European latitudinal gradient

Replicated, factorial mesocosm experiments were conducted across Europe to study the effects of nutrient enrichment and fish density on macrophytes and on periphyton chlorophyll a (chl-a) with regard to latitude. Periphyton chl-a densities and plant decline were significantly related to nutrient loading in all countries. Fish effects were significant in a few sites only, mostly because of their co

Syrgas eller Sobril? Om prioriteringar och val i livets slutskede

Texten fokuserar några valsituationer efter besked om obotlig cancer. Sådant som: Vem ska vi berätta för? Acceptera behandling som kemoterapi eller ej? Ta livet av sig eller ta kampen? Döva sina känslor med medicin eller sträva på med hjälpmedel som syrgas och rullator?

On the coupling of intermolecular polarization and repulsion through pseudo-potentials

To improve the accuracy and transferability of molecular mechanics force fields, one needs a simple physical description of intermolecular polarization based on quantum chemistry. Ideally, in the quantum-chemical description, each molecule is treated separately and the interactions with other molecules are included as a perturbation. We propose a simple formulation of this perturbation, viz. to mo