Background: To date, anal cancer patients are treated with radiotherapy to similar volumes despite a marked difference in risk profile based on tumor location and stage. A more individualized approach to delineation of the elective clinical target volume (CTVe) could potentially provide better oncological outcomes as well as improved quality of life. The aim of the present work was to establish No

To design and develop boxes which protect, and at the same time utilize fiber material efficiently, models and software for predicting corrugated board and box properties are needed. The purpose of this research is to provide propositions toward improving the use and development of models and software for corrugated board and box design. By using an abductive approach, 18 models and four software

Collective intelligence (CI) in demand-side management (DSM) can enhance the flexibility of urban energy systems. Extreme climates cause intensively high loads on the urban energy systems resulting in power outages. To avoid this, quick responses are needed from buildings to adjust their operation in favor of the grid. Most of the available approaches are computationally expensive. CI-DSM offers a

This essay will discuss my work in the interstices between art and cultural analysis. I will expound on how I’ve used a certain concept as part of artistic practice and cultural analytic research. The concept, which I’ve chosen to call Mundania, is used to grapple with the role of emerging technologies in everyday life. The concept is used to discharge imaginations about everyday life characterise

Background: Many children undergo various surgeries, which often lead to acute postoperative pain. This pain influences recovery and quality of life. Non-steroidal anti-inflammatory drugs (NSAIDs), specifically cyclo-oxygenase (COX) inhibitors such as diclofenac, can be used to treat pain and reduce inflammation. There is uncertainty regarding diclofenac's benefits and harms compared to placebo or

BACKGROUND: Health and work environment are known factors in being active in working life beyond legal retirement. OBJECTIVE: To investigate sociodemographic, health and work environment factors as possible predictors of being active in working life at ages 66 and 72. Secondly, investigate eventual changes over time, shortly after a major reform in the Swedish pension system, and predictors of sti

The conflict between seal conservation and fisheries in the Baltic Sea has becomeremarkably serious and threatens the existence of coastal fishing activities in theBaltic Sea. Seals cause significant catch losses, gear damage and various types ofhidden damages and losses. In particular, reports of damage caused by the grey seal,the largest and most common seal species in the Baltic Sea, have incre

The cosmogenic radionuclides 7Be and 10Be are useful tracers for atmospheric transport studies. Combining 7Be and 10Be measurements with an atmospheric transport model can not only improve our understanding of the radionuclide transport and deposition processes but also provide an evaluation of the transport process in the model. To simulate these aerosol tracers, it is critical to evaluate the in

BACKGROUND: Proteomic profiling could potentially disclose new pathophysiological pathways for cardiovascular diseases (CVD) and improve prediction at the individual level. We therefore aimed to study the plasma protein profile associated with the incidence of different CVDs. METHODS: Plasma levels of 245 proteins suspected to be linked to CVD or metabolism were measured in 4 Swedish prospective p

The effect of parental age on germline mutation rate across generations is not fully understood. While some studies report a positive linear relationship of mutation rate with increasing age, others suggest that mutation rate varies with age but not in a linear fashion. We investigated the effect of parental age on germline mutations by generating replicated mutation accumulation lines in Caenorha

BACKGROUND: Several molecular classification systems for bladder cancer have been proposed, but due to differences on how to define molecular subtypes, controversies and misunderstandings have arisen. OBJECTIVE: To discuss different aspects of the molecular classification of bladder cancer and to point to the consequences of using different conceptual approaches. To question some underlying assump

The European XFEL is a research facility that delivers extremely bright and short coherent X-ray pulses of tunable energy at MHz repetition rate, providing unprecedented capabilities to conduct scientific research across multiple domains. Among the suite of deployed detectors, several ePix100 modules, belonging to the family of ePix detectors developed at SLAC, are used. These charge-integrating h