Postural orthostatic tachycardia syndrome (POTS) is a chronic and often disabling disorder characterized by orthostatic intolerance with excessive heart rate increase without hypotension during upright posture. Patients often experience a constellation of other typical symptoms including fatigue, exercise intolerance and gastrointestinal distress. A typical patient with POTS is a female of child-b

This chapter reports preliminary findings from a study of epistemic consequences of misinformation in social networks. It uses the methodology of computer simulation, constructing computer models of Bayesian learning in networks that include untrustworthy sources. Censorship and de-platforming take time and money, and they violate social and democratic norms of inclusiveness and free speech. Enqui

BACKGROUND: Surgical safety during posterior sagittal anorectal plasty (PSARP) for anorectal malformations (ARM) depends on accurate pre-operative fistula localization. This study aimed to evaluate accuracy of pre-operative fistula diagnostics.METHODS: Ethical approval was obtained. Diagnostic accuracy of pre-PSARP symptoms (stool in urine, urine in passive ostomy, urinary tract infection) and exa

Background: Accumulation of alpha-synuclein (α-syn) is a main pathological hallmark of Parkinson’s and related diseases, which are collectively known as synucleinopathies. Growing evidence has supported that the same protein can induce remarkably distinct pathological progresses and disease phenotypes, suggesting the existence of strain difference among α-syn fibrils. Previous studies have shown t

Is audit capable of evolving into something that is more consistently valued and socially purposeful? We address this fundamental question, utilizing Sennett’s (2008). The Craftsman. New Haven: Yale University Press) notion of ‘dynamic repair’ to present four key ways of thinking differently about the statutory financial audit and its core conceptual foundations. First, we highlight the capacity f

This article investigates the microstructure evolution and corrosion response of surface mechanical attrition treated (SMAT) AZ91D magnesium alloy. In-depth transmission electron microscopy and combined isothermal calorimetry and pressure measurement technique, a novel and powerful tool for in situ monitoring of the magnesium corrosion process, are explored in the present study. A gradient structu

This article argues that while HTS’s transformation and split from al-Qaeda is real, al-Jolani must be pressured to share power over Idlib and loosen his group’s authoritarian grip, which is causing grievances that in the long term will push locals into the hands of radical groups like ISIS and al-Qaeda.

This report assesses the phenomenon of in-work poverty in Sweden inrelation to the four specific VUP groups identified within the Working, Yet Poor project. It is shown that the main drivers of in-work poverty in Sweden are not related to the wage setting system as dealt with through collective bargaining as such. Rather, in-work poverty is more closely associated with work-intensity affecting wor

Objective: To evaluate the potential of diffusional variance decomposition (DIVIDE) for grading, molecular feature classification, and microstructural characterization of gliomas. Materials and methods: Participants with suspected gliomas underwent DIVIDE imaging, yielding parameter maps of fractional anisotropy (FA), mean diffusivity (MD), anisotropic mean kurtosis (MKA), isotropic mean kurtosis

The bloom-forming freshwater alga Gonyostomum semen is associated with acidic, mesotrophic brown water lakes in boreal regions. However, researchers have been unable to conclusively link G. semen abundance and bloom formation to typical brown water lake traits, that is, high water color and DOC (dissolved organic carbon) concentrations. Iron is a main driver of water color in boreal lakes, and a r

Unlike pathogens, which attack the host, commensal bacteria create a state of friendly coexistence. Here, we identified a mechanism of bacterial adaptation to the host niche, where they reside. Asymptomatic carrier strains were shown to inhibit RNA polymerase II (Pol II) in host cells by targeting Ser2 phosphorylation, a step required for productive mRNA elongation. Assisted by a rare, spontaneous

Fatal intoxications are common in a medico-legal autopsy setting and are associated with sparse findings during autopsy. It has been suggested that an increased lung weight may be associated with such fatalities. Previous literature is generally limited to a descriptive approach, including only opioid deaths, and lacking a definition of “heavy” lungs. Our aim was to create a model to identify case

This paper presents research on the need for boundary spanners in organizations that has an offshore insourcing strategy for the IT-function. The research question addressed was: How does an offshore insourcing strategy influence the need for having boundary spanners? Empirical data was collected using a case study in three phases, including semi-structured and structured interview in a multinatio

Urban tourism depends on the place specific qualities of destinations. In many cities, climate change poses a threat to these qualities, through increasing risk of excessive heat, draught and flooding. Cities need to adapt to reduce these risks. One way of doing this is to improve their green infrastructure. Urban forests, parks, rivers and wetlands may help reduce the effects of climate change in

The purpose of the study is to report a case of peripheral exudative hemorrhagic chorioretinopathy (PEHCR), managed surgically with favorable visual outcome. A 66-year-old female presented with painless visual loss due to dense vitreous and subretinal hemorrhage extending from the far periphery to the macula. Pars plana vitrectomy (PPV) with subretinal tissue plasminogen activator (TPA) injection

One important step in binary modeling of environmental problems is the generation of absence-datasets that are traditionally generated by random sampling and can undermine the quality of outputs. To solve this problem, this study develops the Absence Point Generation (APG) toolbox which is a Python-based ArcGIS toolbox for automated construction of absence-datasets for geospatial studies. The APG