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Introduction: This study investigated the diagnostic and disease-monitoring potential of plasma biomarkers in mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia and cognitively unimpaired (CU) individuals. Methods: Plasma was analyzed using Simoa assays from 99 CU, 107 MCI, and 103 AD dementia participants. Results: Phosphorylated-tau181 (P-tau181), neurofilament light, amyloid-
Introduction: The prognosis of patients at the pre-dementia stage is difficult to define. The aim of this study is to develop and validate a biomarker-based continuous model for predicting the individual cognitive level at any future moment. In addition to personalized prognosis, such a model could reduce trial sample size requirements by allowing inclusion of a homogenous patient population. Meth
Integrated continuous downstream processes with process analytical technology offer a promising opportunity to reduce production costs and increase process flexibility and adaptability. In this case study, an integrated continuous process was used to purify a recombinant protein on laboratory scale in a two-system setup that can be used as a general downstream setup offering multi-product and mult
Implementing energy efficiency measures in historic buildings is a challenging task and require knowledge in a number of different disciplines. The measures to reduce energy use must create a good indoor environment without jeopardizing the loss of important cultural historical values or entailing damages to building materials or load-bearing structures. Building antiquarian-, building biological-
Integrated continuous downstream processes with process analytical technology offer a promising opportunity to reduce production costs and increase process flexibility and adaptability. In this case study, an integrated continuous process was used to purify a recombinant protein on laboratory scale in a two-system setup that can be used as a general downstream setup offering multiproduct and multi
The overall energy goals mean that more and more extensive measures need to be applied on buildings with varying degrees of heritage value. Previous studies show that there are a number of measures that have a beneficial impact on different parts of the energy system in historic buildings. What is now needed is a holistic approach that provides an opportunity to prioritize which measures are most
Background: The construct of aggression is central to work with violent offenders, but it is a broad construct that can be assessed by many different methods and instruments. Its measurement may, however, have profound implications for treatment planning. We need more knowledge about how different methods for assessing aggression relate to each other. Aims: Our aims were to investigate, first, the
Analysis of the genomic landscape of prostate cancer has identified different molecular subgroups with relevance for novel or existing targeted therapies. The recent approvals of the poly(ADP-ribose) polymerase (PARP) inhibitors olaparib and rucaparib in the metastatic castration-resistant prostate cancer (mCRPC) setting signal the need to embed molecular diagnostics in the clinical pathway of pat
För att öka kunskapen om var studenter med examen i naturvetenskap frånLunds universitet får jobb och hur användbara deras utbildningar är i arbetslivethar vi genomfört en alumnenkät. Alumnenkäten har fokus på interaktionenmellan utbildning och arbetsliv och rör arbete i nära tid efter studierna. Enkätenskickades ut till kandidatalumnerna som tagit ut examen mellan september2017 och september 2018
Hypoxia is of increasing concern in marine areas, calling for a better understanding of mechanisms leading to decreasing dissolved oxygen concentrations ([O2]). Much can be learned about the processes and implications of deoxygenation for marine ecosystems using proxy records from low-oxygen sites, provided proxies, such as the manganese (Mn) to calcium (Ca) ratio in benthic foraminiferal calcite,
Agri-environment schemes are programmes where landholders enter into voluntary agreements (typically with governments) to manage agricultural land for environmental protection and nature conservation objectives. Previous work at local scale has shown that these features can provide additional floral and nesting resources to support wild pollinators, which may indirectly increase floral visitation
Atmospheric heavy elements have been observed in more than a quarter of white dwarfs (WDs) at different cooling ages, indicating ongoing accretion of asteroidal material, whilst only a few per cent of the WDs possess a dust disc, and all these WDs are accreting metals. Here, assuming that a rubble-pile asteroid is scattered inside a WD's Roche lobe by a planet, we study its tidal disruption and th
Background: Biological evolution exhibits an extraordinary capability to adapt organisms to their environments. The explanation for this often takes for granted that random genetic variation produces at least some beneficial phenotypic variation in which natural selection can act. Such genetic evolvability could itself be a product of evolution, but it is widely acknowledged that the immediate sel
Deuterium is a natural low abundance stable hydrogen isotope that in high concentrations negatively affects growth of cells. Here, we have studied growth of Escherichia coli MG1655, a wild-type laboratory strain of E. coli K-12, in deuterated glycerol minimal medium. The growth rate and final biomass in deuterated medium is substantially reduced compared to cells grown in ordinary medium. By using
In this study we describe a methodology to create high-vertical-resolution SO2 profiles from volcanic emissions. We demonstrate the method's performance for the volcanic clouds following the eruption of Sarychev in June 2009. The resulting profiles are based on a combination of satellite SO2 and aerosol retrievals together with trajectory modelling. We use satellite-based measurements, namely lida
Interactions between organisms and their environments are central to how biological diversity arises and how natural populations and ecosystems respond to environmental change. These interactions involve processes by which phenotypes are affected by or respond to external conditions (e.g., via phenotypic plasticity or natural selection) as well as processes by which organisms reciprocally interact
Intrinsic self-healing materials have received significant attention due to the characteristic recovery after damage properties through reversible dynamic covalent and non-covalent interactions. Furthermore, functional recovery with reliable mechanical properties are highly keen as protective coatings, specifically for devices and sensors vulnerable to abrasion in severe environments. Here, we pre
This paper presents INTRACFG, a declarative and language-independent framework for constructing precise intraprocedural control-flow graphs (CFGs) based on the reference attribute grammar system JastAdd. Unlike most other frameworks, which build CFGs on an Intermediate Representation level, e.g., bytecode, our approach superimposes the CFGs on the Abstract Syntax Tree, enabling accurate client ana
