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Ovarian cancer patients are typically treated with carboplatin and paclitaxel, but suffer a high rate of relapse with recalcitrant disease. This challenge has fostered the development of novel approaches to treatment, including antagonists of the 'inhibitor of apoptosis proteins' (IAPs), also called SMAC mimetics, as apoptosis-inducing agents whose action is opposed by caspase inhibitors. Surprisi
This paper presents the features of a survey on Swedish firms’ export decisions conducted in February 2015 focusing on a sample of 10,000 small and medium-sized enterprises. The survey was divided into two major sections. The first section targeted all firms and focused on firms’ general situation (e.g. competition, type of co-operations, etc.). The second section focused on firms’ export decision
This thesis concerns the law/fact distinction in law. The interest it takes in the distinction is not practical, but conceptual. It more specifically concerns the questions: “What is it that is conceptually assumed about something when it is categorized as ‘of law’ or ‘of fact’?” and “What is conceptually assumed about the law when law is distinguished from fact by the use of the law/fact distinctThis thesis concerns the law/fact distinction in law. The interest it takes in the distinction is not practical, but conceptual. It more specifically concerns the questions: “What is it that is conceptually assumed about something when it is categorized as ‘of law’ or ‘of fact’?” and “What is conceptually assumed about the law when law is distinguished from fact by the use of the law/fact distinct
This paper presents an advanced signal processing schemefor time-domain induced polarization full waveform data.The scheme includes several steps with an improvedinduced polarization (IP) response gating design usingconvolution with tapered windows to suppress highfrequency noise, a logarithmic gate width distribution foroptimizing IP data quality and an estimate of gatinguncertainty. Additional s
Bleomycin has, in the years of developing electrochemotherapy (ECT), proven to be an extremely potent drug for this cancer treatment modality and is also the most frequently applied chemical agent. It is of importance to investigate the pharmacokinetics of bleomycin under normal conditions and particularly in combination with ECT.
A DCIP survey, i.e. a geoelectrical survey with combinedmeasurement of DC resistivity and induced polarization(IP), was conducted in southern Sweden. The purposewas to identify soil depth and bedrock structures andvariations in rock quality.Data were acquired data with 100% waveform fromwhich IP of good quality data were extracted. Theinverted model sections show a wide variation in theelectrical
The first attempt to apply electrochemotherapy (ECT) to the brain was reported in 1993 by Salford et al. 1993 (1). They managed to significantly prolong the survival of RG2 glioma bearing Fischer-344 rats by 200% by iv administration of bleomycin followed by intracranial electrochemotherapy with exponential decaying pulses. In collaboration with the department of tumor immunology, Lund University,
This volume discusses various methods and protocols used for the experimentation of a wide range of bacterial species, such as Streptococcus pyogenes, Staphylococcus aureus, Streptococcus pneumonia, Listeria monocytogenes, and Mycobacterium marinum. Bacterial Pathogens: Methods and Protocols is divided into 6 parts: Part 1 describes different approaches to identifying and characterizing bacterial
The current study is focused on determining the optimal tube voltage for the conventional X-ray digital chest screening examinations, using a visual grading analysis method. Chest images of an anthropomorphic phantom were acquired in posterior-anterior projection on four digital X-ray units with different detector types. X-ray images obtained with an anthropomorphic phantom were accepted by the ra
A swirl stabilized gas turbine burner has been simulated in order to assess the effects of the fuel properties on spray dispersion and fuel-air mixing. The properties under consideration include fuel surface tension, viscosity and density. The turbulence of the gas phase is modeled applying the methodology of large eddy simulation whereas the dispersed liquid phase is described by Lagrangian parti
Metal-halide perovskite semiconductors are certainly one of the hottest topic in solar energy conversion. Optimization of both the absorber material and device architecture has led to an astoundingly rapid increase in the reported device efficiencies. Initially developed in the context of dye-sensitized solar cell research, metal-halide perovskite devices now reach efficiency values and hence need
We show that the rotation axis of a triaxial nucleus may flip from the intermediate axis (γ=-30) to the smallest axis (γ=+30) due to the polarization by an aligned T=0np pair. The example we discuss is the triaxial N=Z nucleus Ge64 where the isoscalar π(g9/2)- ν(g9/2) pair aligns to iπ=9+ in As66 and flips the rotation from γ≈-30 to γ≈30. Calculations are performed in the spherical shell model as
The recycling, S-nitrosylated heparan sulfate (HS) proteoglycan glypican-1 releases anhydromannose (anMan)-containing HS chains by a nitrosothiol-catalyzed cleavage in endosomes that can be constitutive or induced by ascorbate. The HS-anMan chains are then transported to the nucleus. A specific nuclear target for HS-anMan has not been identified. We have monitored endosome-to-nucleus trafficking o
