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Loss of lysosomal membrane integrity, often referred to as lysosomal membrane permeabilization (LMP), occurs in many instances of cell death either as an initiating or as an amplifying event. Currently, the best method for detecting LMP is the galectin puncta formation assay which can be used for a broad range of sample types, both fixed and live, is easy to perform, and highly sensitive. This met
Experimental studies of the collisions of heavy nuclei at relativistic energies have established the properties of the quark–gluon plasma (QGP), a state of hot, dense nuclear matter in which quarks and gluons are not bound into hadrons1–4. In this state, matter behaves as a nearly inviscid fluid5 that efficiently translates initial spatial anisotropies into correlated momentum anisotropies among t
Vulture populations worldwide have suffered precipitous declines in recent decades. The Cinereous Vulture Aegypius monachus, a highly philopatric scavenger distributed across southern Europe and the central Asian plateau, is threatened in many parts of its range. Turkey holds the second largest population of this species in the Western Palaearctic, but there has been no research on its genetic str
This paper offers a preliminary assessment of the ASEAN Convention against Trafficking in Persons [ACTIP] and the road leading to ACTIP’s adoption. It argues that ACTIP’s adoption and entry into force represent a growing trend in ASEAN treaty practice, especially on issues of international and regional concern, in which hard and soft obligations are combined to appeal to states’ ratification and t
This dissertation reports on an investigation into how digital tools are used, negotiated and given meaning in Swedish pre-school teacher education. The overall aim has been to create a deeper understanding of how students’ information literacies are enacted when digital tools are used and appropriated in the daily life at a pre-school teacher education, in relation to conceptions of the digitalis
Commenting on Eco's papers about fakes, I claimed that what is meant by a fake depends on what is taken to be the original, and this, in turn, revolves around the relation between type and token. As observed by Prieto and Grice, a sign, apart from the content it conveys, also carries a message informing us that it is a sign. The scare crow is a sign to the addresser, but not, ideally, to the addre
Si la traducción es un acto de transacción de sentidos, la semiótica debeser capaz de definir su especificidad en relación con otros actos semióticos. En lugar de eso, siguiendo a las sugerencias de Roman Jakobson, de la escuela de Tartú y, de forma implícita, de Charles Sanders Peirce, la noción de traducción ha sido generalizada para cubrir más o menos todas las operaciones que se pueden llevar
Previous work indicates that physical robots elicit more favorable social responses than virtual agents. These effects have been attributed to the physical embodiment. However, a recent meta-analysis by Li [1] suggests that the benefits of robots are due to physical presence rather than physical embodiment. To further explore the importance of presence we conducted a pilot study investigating the
Introduction: Long-term oxygen therapy (LTOT) improves survival and may reduce hospital admissions in patients with chronic obstructive pulmonary disease (COPD) and severe hypoxemia, but the impact of daily duration of LTOT on hospitalization rate is unknown. We aimed to estimate the association between the daily duration of LTOT (24 vs 15 h/d) and hospital admissions in patients with LTOT due to
Antiepileptic drugs (AEDs) are effective against seizures, but their use is often limited by adverse effects, among them psychiatric and behavioral ones including aggressive behavior (AB). Knowledge of the incidence, risk factors, and the underlying mechanisms of AB induced by AEDs may help to facilitate management and reduce the risk of such side effects. The exact incidence of AB as an adverse e
