Protein aggregates are a hallmark of Alzheimer's disease (AD). Extensive studies have focused on β-amyloid plaques and Tau tangles. Here, we illustrate a novel source of protein aggregates in AD neurons from organelle off-target proteins. Bax is a mitochondrial pore-forming pro-death protein. What happens to Bax if it fails to target mitochondria? We previously showed that a mitochondrial target-d

This article analyzes the utilization of the concept “Gnosticism” in a form of Satanism that has come to be known as “Chaos Gnosticism,” or “Gnostic Satanism.” The topic of the study is the Swedish expressions of this phenomenon attached to Current 218 and the Temple of Black Light, previously named the Misanthropic Luciferian Order (MLO). The group is known as one of the more radical and violent This article analyzes the utilization of the concept “Gnosticism” in a form of Satanism that has come to be known as “Chaos Gnosticism,” or “Gnostic Satanism.” The topic of the study is the Swedish expression of this phenomenon attached to Current 218 and the Temple of Black Light, previously named the Misanthropic Luciferian Order (MLO). The group is known as one of the more radical and violent f

Psychedelic substances have in recent years attracted considerable interest as potential treatments for several psychiatric conditions, including depression, anxiety, and addiction. Imaging studies in humans point to a number of possible mechanisms underlying the acute effects of psychedelics, including changes in neuronal firing rates and excitability as well as alterations in functional connecti

The profound changes in perception and cognition induced by psychedelic drugs are thought to act on several levels, including increased glutamatergic activity, altered functional connectivity and an aberrant increase in high-frequency oscillations. To bridge these different levels of observation, we have here performed large-scale multi-structure recordings in freely behaving rats treated with 5-H

Introduction There has been a drastic increase in the reported number of people seeking help for gender dysphoria in many countries over the last two decades. Yet, our knowledge of gender dysphoria and related outcomes is restricted due to the lack of high-quality studies employing comprehensive approaches. This longitudinal study aims to enhance our knowledge of gender dysphoria; different aspect

A method based on femtosecond two-photon excitation has been developed for simultaneous visualization of interference-free fluorescence of H and O atoms in turbulent flames. This work shows pioneering results on single-shot simultaneous imaging of these radicals under non-stationary flame conditions. The fluorescence signal, showing the distribution of H and O radicals in premixed CH4/O2 flames wa

Energy balance closure is an important feature in studies of ecosystem exchanges of energy and greenhouse gases using the eddy covariance method. Previous analyses show that this is still a problem with imbalances in the order of 0.6–0.7 to full closure (for only a few sites). It has been suggested that mesoscale transport processes that are not captured by the eddy covariance measurements are the

This paper contributes to academic and policy debates about climate leadership by illustrating an approach to examining national emission reduction targets focusing on Denmark. Widely recognized as a climate leader, Denmark is cherished for both its historical track record and its current climate targets. With a target of 70% emissions reduction by 2030 compared to 1990 stipulated in national law,

Koranbränningar ställer höga principer mot varandra, men begränsningar av opinionsfrihet motiveras alltid med oklanderliga skäl. De historiska perspektiven visar att man ska vara försiktig med att ge vika för uppblossande opinioner. Sverige må vara i minoritet i ett globalt perspektiv, men det gör bara försvaret av vår yttrandefrihet än viktigare, skriver professor Jonas Nordin.

In secondary-school English-as-a-foreign-language (EFL) classrooms worldwide, English tends to be used alongside the society or community majority language (Brevik & Rindal 2020; Tsagari & Diakou 2015; Üstünel 2016), and research reveals greater participation and positive attitudes among students when translanguaging is permitted (Ebe 2016; Kleyn 2016; Saxena 2009; Ollerhead 2019; Seltzer