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Adenoviruses aggregate in the presence of type‐specific antibodies against whole virus particles. These aggregates were found to damage human cells in vitro in far higher order of magnitude than virus alone, when virus and type‐specific antibodies were mixed at a certain virus‐antibody ratio. No cytotoxicity occurred when the virus was mixed with type‐specific antibodies in higher or lower dilutio
Adenovirus antibody aggregates under defined conditions are cytotoxic in vitro. All members of adenovirus groups I, II, and III caused toxicity upon aggregation. The toxicity of the clusters is exerted by the virions. Toxicity is temperature dependent and may be caused by a mechanism similar to that used in viral penetration. Cells permitting direct viral penetration were all sensitive to the toxi
Typhoid disease continues to be a global public health burden. Uganda is one of the African countries characterized by high incidences of typhoid disease. Over 80% of the Ugandan districts are endemic for typhoid, largely attributable to lack of reliable knowledge to support disease surveillance. Spatial-temporal studies exploring major characteristics of the disease within the local population ha
Lung transplantation is the only option for end-stage lung diseases, but organ shortage remains problematic. Generating lungs ex vivo could overcome shortages with current approaches being explored for lung tissue engineering utilizing a biologically derived, synthetic or hybrid scaffold which is seeded with cells and cultured ex vivo. Ideally, cells could be sourced from the transplant recipient
Introduction: The extent to which pain is distributed across the body (spreading of pain) differs largely among patients with chronic pain conditions and widespread pain has been linked to poor quality of life and work disability. A longer duration of pain is expected to be associated with more widespread pain, but studies are surprisingly scarce. Whether spreading of pain is associated with clini
The pathological hallmark of Parkinson’s disease (PD) is the formation of Lewy bodies containing aggregated alpha-synuclein (α-syn). Although PD is associated with these distinct histological changes, other pathological features such as microvascular alterations have been linked to neurodegeneration. These changes need to be investigated as they create a hostile brain microenvironment and may cont
Ptychographic X-ray microscopy is an ideal tool to observe chemical processes under in situ conditions. Chemical reactors, however, are often thicker than the depth of field, limiting the lateral spatial resolution in projection images. To overcome this limit and reach higher lateral spatial resolution, wave propagation within the sample environment has to be taken into account. Here, we demonstra
Sliding mode control (SMC) is to keep the system to a stable differential manifold. Model predictive control (MPC) calculates the control input by solving an optimization problem on receding horizon. The method of receding horizon sliding control (RHSC) includes the predicted information into the SMC design by combining SMC and MPC. Considering the modeling error and measurement noise, there are m
In order to mitigate global warming, it is important to decrease the climate impact from the building stock, which accounts for 39% of the GHG emissions in Europe. An extensive portion of these emissions are generated from the heating of buildings, but emissions also occur from the production of building materials. It is therefore important to find building design solutions that consider both prod
Some foreign policy analysts believe that what we are witnessing in the 21st century is nothing short of a reconfiguring of the global political order - with China firmly positioned at the helm as a (re)emerging great power. At present, the notion of the imminent establishment of a ‘new world order with Chinese characteristics’ is increasingly gaining traction. This sentiment has long permeated fo
Little is known about the impacts of persistent triazine herbicides and biocides on soil microorganisms. Terbutryn toxicity in soil microorganisms was studied using bacterial and fungal growth, substrate induced respiration (SIR) and basal respiration as ecotoxicological end-points. In the short-term (0–7 days), increasing concentrations of terbutryn (0–800 mg kg−1) progressively inhibited bacteri
The elliptic and triangular flow coefficients v2 and v3 of prompt D0, D+, and D⁎+ mesons were measured at midrapidity (|y|<0.8) in Pb–Pb collisions at the centre-of-mass energy per nucleon pair of sNN=5.02TeV with the ALICE detector at the LHC. The D mesons were reconstructed via their hadronic decays in the transverse momentum interval 1
