Nonsense-mediated mRNA decay (NMD) is a eukaryotic quality control system that recognizes and degrades transcripts containing NMD cis elements in their 3'untranslated region (UTR). In yeasts, unusually long 3'UTRs act as NMD cis elements, whereas in vertebrates, NMD is induced by introns located >50 nt downstream from the stop codon. In vertebrates, splicing leads to deposition of exon junction co

High throughput approaches such as whole genome sequencing (WGS) and whole exome sequencing (WES) create an unprecedented amount of data providing powerful resources for clinical care and research. Recently, WGS and WES services have been made available by commercial direct-to-consumer (DTC) companies. The DTC offer of genetic testing (GT) has already brought attention to potentially problematic i

Our international study, 'Your DNA, Your Say', uses film and an online cross-sectional survey to gather public attitudes toward the donation, access and sharing of DNA information. We describe the methodological approach used to create an engaging and bespoke survey, suitable for translation into many different languages. We address some of the particular challenges in designing a survey on the su

The phenotypic adjustments of Mycobacterium tuberculosis are commonly inferred from the analysis of transcript abundance. While mechanisms of transcriptional regulation have been extensively analysed in mycobacteria, little is known about mechanisms that shape the transcriptome by regulating RNA decay rates. The aim of the present study is to identify the core components of the RNA degradosome of

The semantics of programming languages comprise many concepts that are alternatives to each other, such as by-reference and by-value parameter passing. To help teach these concepts, Diwan et al. introduced the programming language Mystery, with fixed syntax but configurable semantics, and described how this language enables new approaches to teaching programming languages concepts. In this paper,

Application-level packet filtering is a technique for network access control in which an “application-level gateway” intercepts network packets at the application level (e.g., HTTP, FTP), scans them for security concerns and optionally logs, rewrites or discards them. Existing application-level filters express their filtering rules in general-purpose languages, which limits the correctness guarant

Research performance studies based on citation data have become of interest both nationally and on the university-level as the focus on quality control has increased also in the higher education sector. Large journal-based indexes, such as Web of Science and recently Scopus, have most frequently been used for the task. These have shown to have limited coverage, especially for areas in the humaniti

Since 2009, the Swedish government has allo-cated a part of its direct funding to the Swed-ish universities based on a bibliometric indica-tor, which stems from the number of publica-tions and citations found in the Web of Science bibliographic database. This paper discusses the creation and detailed structure of the new indicator, which has met criticism from both researchers and the Swedish Rese

As the interest in research performance analysis using bibliometrics increases, more specialised tools are developed. In cases when verified publication data is not available; data is normally collected and aggregated using subject or organisational criteria. The journal subject areas in Thomson Reuters/ISI are often used, but can be poor in their precision and granularity. In an attempt to improv

Institutional repositories are now available at many academic institutions world-wide. Researchers are urged to contribute full-text documents to increase their visibility and accessibility on the web. Recently, a focus on research evaluation has increased the interest in the bibliographic portion of the data as well and an increasing number of institutions have now made it mandatory for their fac

Several new polydentate and potentially dinucleating ligands have been synthesized in order to model the coordination environments of a number of structurally related dinuclear active sites in metalloenzymes, including methane monooxygenase, the ribonucleotide reductase R2 protein, urease, arginase, red kidney bean purple acid phosphatase and zinc phosphotriesterase.~ Ligands 1 and 2 have proven t

While evidence suggests that industry inventors' interactions with universities enhance invention value, the role of interaction governance has so far been overlooked. Relying on an original survey of industry inventors of European patents based in Italy, we show that governance matters. Personal contractual collaborations between firms and individual academics lead to higher-value inventions than

Iris Marion Young presents a social connection model on which those, and only those, who participate in structural processes that produce injustice have a forward-looking responsibility to redress the resulting injustice by challenging the structures that produce it (she sometimes calls this a political responsibility [Young 2011]). In Young's view, this is an all-things-considered, albeit discretIris Marion Young presents a social connection model on which those, and only those, who participate in structural processes that produce injustice have a forward-looking responsibility to redress the resulting injustice by challenging the structures that produce it (she sometimes calls this a political responsibility [Young 2011]). In Young's view, this is an all-things-considered, albeit discret

There is a clear demand to increase detection depths in the context of raw material exploration programs. Semi-airborne electromagnetic (semi-AEM) methods can address these demands by combining the advantages of powerful transmitters deployed on the ground with efficient helicopter-borne mapping of the magnetic field response in the air.The penetration depth can exceed those of classical airborne

Precise thermometry is of wide importance in science and technology in general and in quantum systems in particular. Here, we investigate fundamental precision limits for thermometry on cold quantum systems, taking into account constraints due to finite measurement resolution. We derive a tight bound on the optimal precision scaling with temperature, as the temperature approaches zero. The bound d